AR217617A1 - Procedimiento para la preparacion de nuevos compuestos esteroides derivados de los 14-hidroxi-17 beta-(4-piridazinil)-5 beta,14 beta-androstanos,particularmenmente utiles como agentes cardiotonicos y sus derivados glucosidos - Google Patents
Procedimiento para la preparacion de nuevos compuestos esteroides derivados de los 14-hidroxi-17 beta-(4-piridazinil)-5 beta,14 beta-androstanos,particularmenmente utiles como agentes cardiotonicos y sus derivados glucosidosInfo
- Publication number
- AR217617A1 AR217617A1 AR259928A AR25992875A AR217617A1 AR 217617 A1 AR217617 A1 AR 217617A1 AR 259928 A AR259928 A AR 259928A AR 25992875 A AR25992875 A AR 25992875A AR 217617 A1 AR217617 A1 AR 217617A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- androstanos
- piridazinyl
- hydroxy
- procedure
- Prior art date
Links
- -1 STEROID COMPOUNDS Chemical class 0.000 title 1
- 239000000496 cardiotonic agent Substances 0.000 title 1
- 229930182470 glycoside Natural products 0.000 title 1
- 150000002338 glycosides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1085574A CH621803A5 (cs) | 1974-08-08 | 1974-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR217617A1 true AR217617A1 (es) | 1980-04-15 |
Family
ID=4367535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR259928A AR217617A1 (es) | 1974-08-08 | 1975-08-07 | Procedimiento para la preparacion de nuevos compuestos esteroides derivados de los 14-hidroxi-17 beta-(4-piridazinil)-5 beta,14 beta-androstanos,particularmenmente utiles como agentes cardiotonicos y sus derivados glucosidos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4000125A (cs) |
| JP (1) | JPS5141372A (cs) |
| AR (1) | AR217617A1 (cs) |
| BE (1) | BE832271A (cs) |
| CA (1) | CA1049499A (cs) |
| CH (1) | CH621803A5 (cs) |
| DE (1) | DE2534981A1 (cs) |
| DK (1) | DK139101B (cs) |
| ES (1) | ES440110A1 (cs) |
| FR (1) | FR2281124A1 (cs) |
| GB (1) | GB1484655A (cs) |
| SE (1) | SE418401B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1144136B (it) * | 1980-03-05 | 1986-10-29 | Zenyaku Kogyo Kk | Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione |
| US5373095A (en) * | 1985-10-18 | 1994-12-13 | The Upjohn Company | Steroid compounds |
| IT1262931B (it) * | 1992-01-16 | 1996-07-22 | Zambon Spa | Composti steroidei 17(piridazin-n-ossido)-sostituiti attivi sul sistema cardiovascolare |
| DE4227616C2 (de) * | 1992-08-20 | 1995-04-13 | Sigma Tau Ind Farmaceuti | 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen |
| DK2206719T3 (en) * | 2005-03-02 | 2015-01-26 | Univ Maryland | A pharmaceutical composition comprising 3-BETA-HYDROXY-17- (1-H-benzimidazol-1-yl) androsta-5, 16-DIEN |
| GB2470873A (en) * | 2008-03-12 | 2010-12-08 | Univ Maryland | Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer |
| US20100048914A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2009120565A2 (en) | 2008-03-25 | 2009-10-01 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| US8785423B2 (en) * | 2008-04-14 | 2014-07-22 | University Of Maryland, Baltimore | Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases |
| WO2010091303A1 (en) | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel steroidal cyp17 inhibitors/antiandrogens |
| EP3023433A1 (en) | 2009-02-05 | 2016-05-25 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| BR112012002797A2 (pt) | 2009-08-07 | 2019-09-24 | Tokai Pharmaceuticals Inc | tratamento de câncer de próstata |
| SG11201507093WA (en) | 2013-03-14 | 2015-10-29 | Univ Maryland Baltimore Office Of Technology Transfer | Androgen receptor down-regulating agents and uses thereof |
| KR20160058774A (ko) | 2013-08-12 | 2016-05-25 | 토카이 파마슈티컬, 아이엔씨. | 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커 |
| US11053279B2 (en) * | 2015-06-29 | 2021-07-06 | Universiteit Gent | Methods for the site-selective coupling of a first agent to a second agent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3838163A (en) * | 1968-11-22 | 1974-09-24 | Hoffmann La Roche | Substituted isoxazole derivatives as steroid intermediates |
-
1974
- 1974-08-08 CH CH1085574A patent/CH621803A5/it not_active IP Right Cessation
-
1975
- 1975-07-29 GB GB31789/75A patent/GB1484655A/en not_active Expired
- 1975-07-30 US US05/600,485 patent/US4000125A/en not_active Expired - Lifetime
- 1975-08-05 DE DE19752534981 patent/DE2534981A1/de not_active Ceased
- 1975-08-07 DK DK358875AA patent/DK139101B/da unknown
- 1975-08-07 FR FR7524701A patent/FR2281124A1/fr active Granted
- 1975-08-07 JP JP50095475A patent/JPS5141372A/ja active Pending
- 1975-08-07 SE SE7508908A patent/SE418401B/xx unknown
- 1975-08-07 AR AR259928A patent/AR217617A1/es active
- 1975-08-07 CA CA233,045A patent/CA1049499A/en not_active Expired
- 1975-08-08 BE BE159066A patent/BE832271A/xx unknown
- 1975-08-08 ES ES440110A patent/ES440110A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE832271A (fr) | 1975-12-01 |
| GB1484655A (en) | 1977-09-01 |
| DK139101C (cs) | 1979-05-21 |
| US4000125A (en) | 1976-12-28 |
| SE7508908L (sv) | 1976-02-09 |
| SE418401B (sv) | 1981-05-25 |
| CA1049499A (en) | 1979-02-27 |
| DK139101B (da) | 1978-12-18 |
| DE2534981A1 (de) | 1976-02-19 |
| DK358875A (cs) | 1976-02-09 |
| ES440110A1 (es) | 1977-02-16 |
| FR2281124B1 (cs) | 1980-05-16 |
| CH621803A5 (cs) | 1981-02-27 |
| JPS5141372A (cs) | 1976-04-07 |
| FR2281124A1 (fr) | 1976-03-05 |
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