AR128705A1 - Excipientes de heteropolímeros aleatorios para formulaciones de alta concentración de proteínas - Google Patents
Excipientes de heteropolímeros aleatorios para formulaciones de alta concentración de proteínasInfo
- Publication number
- AR128705A1 AR128705A1 ARP230100547A ARP230100547A AR128705A1 AR 128705 A1 AR128705 A1 AR 128705A1 AR P230100547 A ARP230100547 A AR P230100547A AR P230100547 A ARP230100547 A AR P230100547A AR 128705 A1 AR128705 A1 AR 128705A1
- Authority
- AR
- Argentina
- Prior art keywords
- polymers
- random
- collection
- methacrylate
- protein
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 239000000546 pharmaceutical excipient Substances 0.000 title abstract 2
- 229920000140 heteropolymer Polymers 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 11
- 238000000034 method Methods 0.000 abstract 5
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 abstract 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
- RUMACXVDVNRZJZ-UHFFFAOYSA-N 2-methylpropyl 2-methylprop-2-enoate Chemical compound CC(C)COC(=O)C(C)=C RUMACXVDVNRZJZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000010560 atom transfer radical polymerization reaction Methods 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- 238000010526 radical polymerization reaction Methods 0.000 abstract 2
- GTZCNONABJSHNM-UHFFFAOYSA-N 5,10,15,20-tetraphenyl-21,23-dihydroporphyrin zinc Chemical compound [Zn].c1cc2nc1c(-c1ccccc1)c1ccc([nH]1)c(-c1ccccc1)c1ccc(n1)c(-c1ccccc1)c1ccc([nH]1)c2-c1ccccc1 GTZCNONABJSHNM-UHFFFAOYSA-N 0.000 abstract 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical group NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000012986 chain transfer agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- DUDCYUDPBRJVLG-UHFFFAOYSA-N ethoxyethane methyl 2-methylprop-2-enoate Chemical compound CCOCC.COC(=O)C(C)=C DUDCYUDPBRJVLG-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000013467 fragmentation Methods 0.000 abstract 1
- 238000006062 fragmentation reaction Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/14—Methyl esters, e.g. methyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1811—C10or C11-(Meth)acrylate, e.g. isodecyl (meth)acrylate, isobornyl (meth)acrylate or 2-naphthyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F220/28—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
- C08F220/285—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety
- C08F220/286—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety and containing polyethylene oxide in the alcohol moiety, e.g. methoxy polyethylene glycol (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente solicitud se refiere a colecciones de polímeros aleatorios y polímeros específicos que se pueden usar, por ejemplo, para estabilizar composiciones de proteína en alta concentración, tales como composiciones de anticuerpo en alta concentración. Reivindicación 1: Una colección de polímeros aleatorios que comprende una mezcla de polímeros, en donde la colección comprende polímeros que comprenden al menos tres monómeros elegidos de: a. metacrilato de metilo (MMA), b. metacrilato de oligo(etilenglicol) metil éter (OEGMA), c. metacrilato de isobutilo (IBMA) o metacrilato de butilo (BMA), y d. un compuesto de la fórmula (1), en donde R¹ es O o NH, R² es metilo, etilo, propilo o butilo, y R³ es NH₂ o N(CH₃)₂ o un grupo guanidinio, en donde la colección comprende polímeros de 3 a 20 kDa. Reivindicación 57: Un método para reducir la viscosidad y/o inhibir la precipitación de una composición que contiene proteína, que comprende agregar un polímero aleatorio de acuerdo con cualquiera de las reivindicaciones 27 - 49 a la composición, opcionalmente en donde la composición comprende la proteína y/o excipientes de acuerdo con cualquiera de las reivindicaciones 50 - 56. Reivindicación 58: Un método para preparar una colección de polímeros aleatorios de acuerdo con cualquiera de las reivindicaciones 1 - 26 o un polímero aleatorio de acuerdo con cualquiera de las reivindicaciones 27 - 49, en donde el método comprende transferencia de cadena de adición-fragmentación reversible (RAFT), polimerización de radicales libres (FRP) o polimerización de radicales por transferencia de átomos (ATRP). Reivindicación 59: Un método para preparar una colección de polímeros aleatorios de acuerdo con cualquiera de las reivindicaciones 1 - 26 o un polímero aleatorio de acuerdo con cualquiera de las reivindicaciones 27 - 49, en donde el método comprende: exponer los monómeros a luz LED y/o calor en presencia de un catalizador de tetrafenilporfirina de zinc (ZnTPP) y un agente de transferencia de cadena.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263317648P | 2022-03-08 | 2022-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR128705A1 true AR128705A1 (es) | 2024-06-05 |
Family
ID=85800768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230100547A AR128705A1 (es) | 2022-03-08 | 2023-03-06 | Excipientes de heteropolímeros aleatorios para formulaciones de alta concentración de proteínas |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR128705A1 (es) |
| AU (1) | AU2023232080A1 (es) |
| IL (1) | IL314985A (es) |
| TW (1) | TW202345898A (es) |
| WO (1) | WO2023172864A1 (es) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3147335A1 (en) * | 2015-09-23 | 2017-03-29 | BYK-Chemie GmbH | Colorant compositions containing wettting and/or dispersing agents with low amine number |
| EP3559120A4 (en) * | 2016-12-22 | 2020-10-07 | Commonwealth Scientific and Industrial Research Organisation | AQUEOUS POLYMER COMPOSITION |
| JP2019142787A (ja) * | 2018-02-16 | 2019-08-29 | Jsr株式会社 | タンパク安定化剤 |
| WO2021226351A1 (en) * | 2020-05-08 | 2021-11-11 | Rutgers, The State University Of New Jersey | Methods and systems for stabilizing proteins using intelligent automation |
-
2023
- 2023-03-06 WO PCT/US2023/063767 patent/WO2023172864A1/en active Application Filing
- 2023-03-06 TW TW112108008A patent/TW202345898A/zh unknown
- 2023-03-06 AR ARP230100547A patent/AR128705A1/es unknown
- 2023-03-06 AU AU2023232080A patent/AU2023232080A1/en active Pending
- 2023-03-06 IL IL314985A patent/IL314985A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2023232080A1 (en) | 2024-08-01 |
| TW202345898A (zh) | 2023-12-01 |
| IL314985A (en) | 2024-10-01 |
| WO2023172864A1 (en) | 2023-09-14 |
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