AR128689A1 - Anticuerpos 3e10 humanizados, variantes y fragmentos de unión al antígeno de los mismos - Google Patents
Anticuerpos 3e10 humanizados, variantes y fragmentos de unión al antígeno de los mismosInfo
- Publication number
- AR128689A1 AR128689A1 ARP230100530A ARP230100530A AR128689A1 AR 128689 A1 AR128689 A1 AR 128689A1 AR P230100530 A ARP230100530 A AR P230100530A AR P230100530 A ARP230100530 A AR P230100530A AR 128689 A1 AR128689 A1 AR 128689A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- antigen
- humanized
- antibodies
- amino acid
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 6
- 102000036639 antigens Human genes 0.000 title abstract 6
- 108091007433 antigens Proteins 0.000 title abstract 6
- 239000012634 fragment Substances 0.000 title abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La descripción proporciona anticuerpos 3E10 humanizados y fragmentos de unión al antígeno de los mismos. También se describen las composiciones y métodos para usar los anticuerpos 3E10 humanizados y los fragmentos de unión al antígeno de los mismos para suministrar la carga. Reivindicación 1: Un anticuerpo 3E10 humanizado o fragmento de unión al antígeno del mismo que comprende un dominio variable de la cadena ligera (3E10-VL) y un dominio variable de la cadena pesada (3E10-VH), en donde: la 3E10-VL comprende una secuencia de aminoácidos que es al menos 97% idéntica a una secuencia de aminoácidos seleccionada del grupo que consiste en 3E10-VL-h1 (SEQ ID Nº 85), 3E10-VL-h2 (SEQ ID Nº 86), 3E10-VL-h3 (SEQ ID Nº 87), 3E10-VL-h4 (SEQ ID Nº 88), 3E10-VL-h5 (SEQ ID Nº 89) y 3E10-VL-h6 (SEQ ID Nº 90), y la 3E10-VH comprende una secuencia de aminoácidos que es al menos 95% idéntica a una secuencia de aminoácidos seleccionada del grupo que consiste en 3E10-VH-h1 (SEQ ID Nº 64), 3E10-VH-h2 (SEQ ID Nº 65), 3E10-VH-h3 (SEQ ID Nº 66), 3E10-VH-h4 (SEQ ID Nº 67), 3E10-VH-h5 (SEQ ID Nº 68), 3E10- VH-h6 (SEQ ID Nº 69) y 3E10-VH-h7 (SEQ ID Nº 70). Reivindicación 78: Una composición que comprende un complejo no covalente de: (i) un anticuerpo 3E10 humanizado o fragmento de unión al antígeno del mismo de acuerdo con una cualquiera de las reivindicaciones 1 - 77 y (ii) un polinucleótido. Reivindicación 158: Un polinucleótido que codifica el anticuerpo 3E10 humanizado o fragmento de unión al antígeno del mismo de acuerdo con una cualquiera de las reivindicaciones 1 - 77. Reivindicación 159: Una célula hospedera que alberga la composición de polinucleótido de acuerdo con la reivindicación 158.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202263316338P | 2022-03-03 | 2022-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR128689A1 true AR128689A1 (es) | 2024-06-05 |
Family
ID=85772764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP230100530A AR128689A1 (es) | 2022-03-03 | 2023-03-02 | Anticuerpos 3e10 humanizados, variantes y fragmentos de unión al antígeno de los mismos |
Country Status (4)
Country | Link |
---|---|
US (1) | US20230303719A1 (es) |
AR (1) | AR128689A1 (es) |
TW (1) | TW202346364A (es) |
WO (1) | WO2023168352A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024145398A1 (en) | 2022-12-27 | 2024-07-04 | Yale University | Antibody drug conjugates |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4812397A (en) | 1987-02-10 | 1989-03-14 | The Regents Of The University Of California | MAB-anti-DNA related to nephritis |
WO1989007142A1 (en) | 1988-02-05 | 1989-08-10 | Morrison Sherie L | Domain-modified constant region antibodies |
US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
AU707440B2 (en) | 1994-03-29 | 1999-07-08 | Celltech Therapeutics Limited | Antibodies against E-selectin |
AU709503B2 (en) | 1996-03-08 | 1999-09-02 | Regents Of The University Of California, The | Delivery system using mAb 3E10 and mutants and/or functional fragments thereof |
ES2694002T3 (es) | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
DE60143544D1 (de) | 2000-12-12 | 2011-01-05 | Medimmune Llc | Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung |
US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
CA2527878A1 (en) | 2003-05-30 | 2005-01-27 | Alexion Pharmaceuticals, Inc. | Antibodies and fusion proteins that include engineered constant regions |
EP1664116A4 (en) | 2003-08-22 | 2009-06-03 | Biogen Idec Inc | IMPROVED ANTIBODIES WITH CHANGED EFFECTOR FUNCTION AND MANUFACTURING METHOD THEREFOR |
US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
ES2911034T3 (es) | 2006-08-08 | 2022-05-17 | Univ Bonn Rheinische Friedrich Wilhelms | Estructura y uso de oligonucleótidos 5' fosfato |
PT2176408E (pt) | 2008-01-31 | 2015-04-23 | Curevac Gmbh | Ácidos nucleicos compreendendo a fórmula (nuglxmgnnv)a e os seus derivados como agentes/adjuvantes imunoestimuladores |
US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
WO2010002851A1 (en) | 2008-06-30 | 2010-01-07 | Alnylam Pharmaceuticals, Inc. | Silencing and rig-1 activation by dual function oligonucleotides |
ME02568B (me) | 2009-11-30 | 2017-02-20 | Janssen Biotech Inc | MUTIRANA Fc ANTITELA SA UKLONJENOM EFEKTORSKOM FUNKCIJOM |
CA2799595C (en) | 2010-05-27 | 2022-08-16 | Merck Sharp & Dohme Corp. | Method for preparing antibodies having improved properties |
CA2828289C (en) | 2011-03-29 | 2020-07-21 | Roche Glycart Ag | Antibody fc variants |
EP2773760B2 (en) | 2011-10-31 | 2020-11-04 | RiboxX GmbH | Double-stranded rna for immunostimulation |
US9283272B2 (en) | 2012-03-30 | 2016-03-15 | The United States Of America As Represented By The Department Of Veterans Affairs | Targeting intracellular target-binding determinants with intracellular antibodies |
EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
US9861574B2 (en) | 2013-04-09 | 2018-01-09 | Duke University | 2-fluoro-modified RNAs as immunostimulators |
US9775894B2 (en) | 2013-07-09 | 2017-10-03 | University Of Washington Through Its Center For Commercialization | Methods and compositions for activation of innate immune responses through RIG-I like receptor signaling |
JP6709733B2 (ja) * | 2014-01-13 | 2020-06-17 | バレリオン セラピューティクス, エルエルシー | 内在化部分 |
EP3194450A1 (en) | 2014-08-28 | 2017-07-26 | Yale University | Multivalent fragments of antibody 3e10 and methods of use thereof |
DE102015008536A1 (de) | 2015-07-02 | 2017-01-05 | Rheinische Friedrich-Wilhelms-Universität Bonn | Diskontinuierliche Oligonukleotid-Liganden |
WO2017079369A2 (en) | 2015-11-03 | 2017-05-11 | Glaxosmithkline Llc | Novel antibodies |
KR20220143151A (ko) | 2016-04-01 | 2022-10-24 | 바이셀릭스, 인크. | 신규 rna 구축물 및 세포독성 세포 및 줄기 세포의 치료 효과를 증진시키기 위한 그의 사용 방법 |
US11590242B2 (en) | 2016-06-15 | 2023-02-28 | Yale University | Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors |
CN109790216A (zh) | 2016-10-06 | 2019-05-21 | 葛兰素史克知识产权开发有限公司 | 与工艺杂质的结合降低的抗体 |
JP7062669B2 (ja) | 2016-12-23 | 2022-05-06 | ブリストル-マイヤーズ スクイブ カンパニー | 改善されたバイオアナリシス特性およびバイオプロセシング特性のための、治療用免疫グロブリンg4の設計 |
EP3600342B1 (en) | 2017-03-24 | 2021-06-23 | Rigontec GmbH | Method for designing rig-i ligands |
EP3655432A4 (en) * | 2017-07-17 | 2021-04-14 | Nucleus Therapeutics Pty Ltd | BINDING PROTEIN 1 |
EP3740577A4 (en) | 2018-01-17 | 2021-10-20 | Nanyang Technological University | SMALL RNA MOLECULES IN IMMUNOMODULATOR HAIRPIN |
WO2019152808A1 (en) | 2018-02-01 | 2019-08-08 | Yale University | Compositions and methods for inhibition of nuclear-penetrating antibodies |
US20210054102A1 (en) | 2018-02-01 | 2021-02-25 | Yale University | Compositions and methods for enhancing nuclear translocation |
AU2019215191A1 (en) | 2018-02-02 | 2020-09-17 | University Of Washington | Compositions and methods for inducing tripartite motif-containing protein 16 (trim16) signaling |
CA3093715A1 (en) | 2018-04-19 | 2019-10-24 | Checkmate Pharmaceuticals, Inc. | Synthetic rig-i-like receptor agonists |
EP3781687A4 (en) | 2018-04-20 | 2022-02-09 | Merck Sharp & Dohme Corp. | NEW RIG-I SUBSTITUTED AGONISTS: COMPOSITIONS AND METHODS THEREOF |
CN112672748A (zh) | 2018-06-20 | 2021-04-16 | 耶鲁大学 | Rig-i激动剂以及使用其的治疗 |
SG11202101984PA (en) | 2018-08-31 | 2021-03-30 | Univ Yale | Compositions and methods for enhancing triplex and nuclease-based gene editing |
US20210340280A1 (en) | 2018-08-31 | 2021-11-04 | Yale University | Compositions and methods for enhancing donor oligonucleotide-based gene editing |
WO2020260547A1 (en) | 2019-06-27 | 2020-12-30 | Rigontec Gmbh | Design method for optimized rig-i ligands |
WO2021076713A1 (en) | 2019-10-16 | 2021-04-22 | Somalogic, Inc. | Nucleic acid compounds that bind to retinoic acid-inducible gene i protein |
WO2023278897A1 (en) | 2021-07-02 | 2023-01-05 | Yale University | Compositions and methods for treating cancers |
-
2023
- 2023-03-02 AR ARP230100530A patent/AR128689A1/es unknown
- 2023-03-02 US US18/177,571 patent/US20230303719A1/en active Pending
- 2023-03-02 WO PCT/US2023/063605 patent/WO2023168352A1/en unknown
- 2023-03-03 TW TW112107814A patent/TW202346364A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20230303719A1 (en) | 2023-09-28 |
TW202346364A (zh) | 2023-12-01 |
WO2023168352A1 (en) | 2023-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR110979A1 (es) | Moléculas de unión a cd70 y métodos de uso de las mismas | |
AR126242A2 (es) | Tratamiento del cáncer utilizando receptores de antígenos quiméricos | |
AR128689A1 (es) | Anticuerpos 3e10 humanizados, variantes y fragmentos de unión al antígeno de los mismos | |
AR106184A1 (es) | Proteínas de unión a pd-1 y sus métodos de uso | |
AR112257A1 (es) | Anticuerpos multiespecíficos dirigidos al vih-1 gp120 y cd3 humana, composiciones que los comprende, ácido nucleico, vector y célula huésped relacionados, método para producirlos, método para detectar células que expresan gp120 y cd3, kit de anticuerpos, fragmentos de anticuerpo que se une a gp120 y método para producirlos | |
AR109264A1 (es) | Proteínas de unión semejantes a anticuerpo biespecíficas que se unen específicamente a cd3 y cd123 | |
CL2008003004A1 (es) | Anticuerpo anti-esclerostina o su porción de enlace de antígeno; polinucleotido que lo codifica; vector; célula; proceso de producción; composición farmacéutica que lo comprende; método para identificar células y su uso para tratar trastornos óseos. | |
BR112018072140A2 (pt) | anticorpos anti-basigin humanizados e uso dos mesmos | |
PE20230385A1 (es) | Anticuerpos anti-phf-tau y usos de estos | |
PE20231078A1 (es) | Anticuerpos anti-tigit | |
AR110755A1 (es) | Anticuerpos dirigidos a hueso | |
AR124084A1 (es) | ANTICUERPOS DE CADENA PESADA QUE SE UNEN AL RECEPTOR a DE FOLATO | |
PE20220763A1 (es) | Materiales y metodos para modular la inmunidad mediada por celulas t | |
RU2011104709A (ru) | Фармацевтическая композиция для лечения и предупреждения рака | |
EA202192508A1 (ru) | Способы получения композиций антитела к фно | |
AR083971A1 (es) | Anticuerpos antiproliferacion humanizados homogeneos | |
AR128688A1 (es) | Anticuerpos anti-cd39 y uso de los mismos | |
AR127271A1 (es) | Anticuerpos biespecíficos que se unen específicamente a cd47 y cd20, y usos de los mismos | |
AR126154A1 (es) | Agentes aglutinantes biespecíficos que se unen a cldn18.2 y cd3 | |
AR125488A1 (es) | Proteínas de unión biespecíficas de pd-1 y de tigit, y usos de las mismas | |
AR127273A1 (es) | Anticuerpos biespecíficos que se unen específicamente a cd47 y her2 y usos de los mismos | |
AR126578A1 (es) | Anticuerpos anti-ccr8 | |
AR116937A1 (es) | Anticuerpo monoclonal que se une específicamente al antígeno cd20 | |
PE20231093A1 (es) | Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas | |
EA202192505A1 (ru) | Способы получения композиций антитела к фно |