AR128119A1 - Método para producir n-alquilaminoácido y péptido que contiene n-alquilaminoácido - Google Patents
Método para producir n-alquilaminoácido y péptido que contiene n-alquilaminoácidoInfo
- Publication number
- AR128119A1 AR128119A1 ARP220103601A ARP220103601A AR128119A1 AR 128119 A1 AR128119 A1 AR 128119A1 AR P220103601 A ARP220103601 A AR P220103601A AR P220103601 A ARP220103601 A AR P220103601A AR 128119 A1 AR128119 A1 AR 128119A1
- Authority
- AR
- Argentina
- Prior art keywords
- ester
- acid
- alkylaminoacid
- monoalkylamino
- producing
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 229940100198 alkylating agent Drugs 0.000 abstract 2
- 239000002168 alkylating agent Substances 0.000 abstract 2
- 230000029936 alkylation Effects 0.000 abstract 2
- 238000005804 alkylation reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003054 catalyst Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- -1 methyl halide Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se proporciona un método para producir un N-monoalquilaminoácido o un éster de este o un péptido que contiene el N-monoalquilaminoácido o un éster de este, el método que comprende un paso de alquilación que consiste en mezclar un aminoácido inicial o un éster de este o un péptido que contiene el aminoácido inicial o un éster de este, un agente alquilante primario C₁-C₆ o un haluro de metilo sustituido y un catalizador en un disolvente en la presencia de hidrógeno, donde el paso de alquilación se lleva a cabo a una presión de 1 atm o más y produce un N-monoalquilaminoácido o un éster de este o un péptido que contiene el N-monoalquilaminoácido o un éster de este en el cual un grupo alquilo primario correspondiente al agente alquilante primario C₁-C₆ o el haluro de metilo sustituido se une a un grupo amino del aminoácido inicial o un éster de este.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021214900 | 2021-12-28 | ||
| JP2022168608 | 2022-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR128119A1 true AR128119A1 (es) | 2024-03-27 |
Family
ID=86999039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220103601A AR128119A1 (es) | 2021-12-28 | 2022-12-27 | Método para producir n-alquilaminoácido y péptido que contiene n-alquilaminoácido |
Country Status (7)
| Country | Link |
|---|---|
| JP (2) | JP7430297B2 (es) |
| AR (1) | AR128119A1 (es) |
| AU (1) | AU2022428318A1 (es) |
| CA (1) | CA3237911A1 (es) |
| IL (1) | IL312468A (es) |
| TW (1) | TW202342495A (es) |
| WO (1) | WO2023127869A1 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1010063C2 (nl) | 1998-09-10 | 2000-03-13 | Holland Sweetener Co | Werkwijze voor de bereiding van neotaam. |
| JP7232758B2 (ja) | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| KR20210102326A (ko) | 2018-12-12 | 2021-08-19 | 추가이 세이야쿠 가부시키가이샤 | 분자내 수소 결합 가능한 작용기를 갖는 아미노산과 그들 아미노산을 포함하는 펩타이드 화합물, 및 그들의 제조 방법 |
| KR20210139366A (ko) | 2019-03-15 | 2021-11-22 | 추가이 세이야쿠 가부시키가이샤 | 방향족 아미노산 유도체의 제조 방법 |
| PE20221323A1 (es) | 2019-11-07 | 2022-09-09 | Chugai Pharmaceutical Co Ltd | Compuesto de peptidos ciclicos que tiene accion inhibidora de kras |
-
2022
- 2022-12-27 IL IL312468A patent/IL312468A/en unknown
- 2022-12-27 CA CA3237911A patent/CA3237911A1/en active Pending
- 2022-12-27 AU AU2022428318A patent/AU2022428318A1/en active Pending
- 2022-12-27 JP JP2023568520A patent/JP7430297B2/ja active Active
- 2022-12-27 TW TW111150100A patent/TW202342495A/zh unknown
- 2022-12-27 WO PCT/JP2022/048135 patent/WO2023127869A1/ja active Application Filing
- 2022-12-27 AR ARP220103601A patent/AR128119A1/es unknown
-
2024
- 2024-01-30 JP JP2024011686A patent/JP2024052694A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023127869A1 (ja) | 2023-07-06 |
| AU2022428318A1 (en) | 2024-05-16 |
| TW202342495A (zh) | 2023-11-01 |
| CA3237911A1 (en) | 2023-07-06 |
| IL312468A (en) | 2024-06-01 |
| JPWO2023127869A1 (es) | 2023-07-06 |
| JP2024052694A (ja) | 2024-04-11 |
| JP7430297B2 (ja) | 2024-02-09 |
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