AR126626A1 - AGENTE PARA INDUCIR INMUNIDAD ESPECÍFICA CONTRA EL VIRUS DEL SÍNDROME RESPIRATORIO AGUDO SEVERO SARS-CoV-2 EN FORMA LÍQUIDA (VARIANTES) - Google Patents

AGENTE PARA INDUCIR INMUNIDAD ESPECÍFICA CONTRA EL VIRUS DEL SÍNDROME RESPIRATORIO AGUDO SEVERO SARS-CoV-2 EN FORMA LÍQUIDA (VARIANTES)

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Publication number
AR126626A1
AR126626A1 ARP220100254A ARP220100254A AR126626A1 AR 126626 A1 AR126626 A1 AR 126626A1 AR P220100254 A ARP220100254 A AR P220100254A AR P220100254 A ARP220100254 A AR P220100254A AR 126626 A1 AR126626 A1 AR 126626A1
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Argentina
Prior art keywords
seq
cov
agent
sars
liquid form
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ARP220100254A
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English (en)
Inventor
Olga Vadimovna Zubkova
Tatiana Andreevna Ozharovskaia
Inna Vadimovna Dolzhikova
Olga Popova
Dmitrii Viktorovich Shchebliakov
Daria Mikhailovna Grousova
Alina Shahmirovna Dzharullaeva
Amir Ildarovich Tukhvatulin
Natalia Mikhailovna Tukhvatulina
Dmitrii Nikolaevich Shcherbinin
Ilias Bulatovich Esmagambetov
Elizaveta Aleksandrovna Tokarskaya
Andrei Gennadevich Botikov
Alina Sergeevna Eroxova
Fatima Magomedovna Izhaeva
Natalia Anatolevna Nikitenko
Nadezhda Leonidovna Lubenets
Aleksandr Sergeevich Semikhin
Sergei Vladimirovich Borisevich
Boris Savelievich Naroditsky
Denis Yuryevich Logunov
Aleksandr Leonidovich Gintsburg
Original Assignee
Federal State Budgetary Institution “National Res Centre For Epidemiology And Microbiology Named Aft
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Application filed by Federal State Budgetary Institution “National Res Centre For Epidemiology And Microbiology Named Aft filed Critical Federal State Budgetary Institution “National Res Centre For Epidemiology And Microbiology Named Aft
Publication of AR126626A1 publication Critical patent/AR126626A1/es

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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Abstract

Campo: Medicina. Sustancia: La invención se relaciona con biotecnología, inmunología y virología. Se describe un medio para inducir inmunidad específica contra el virus del síndrome respiratorio agudo severo SARS-CoV-2 en forma líquida, que contiene como único componente activo un vector de expresión basado en el genoma de la cepa recombinante del adenovirus humano de serotipo 26, en el que están eliminadas las regiones E1 y E3, y la región ORF6-Ad26 está reemplazada por ORF6-Ad5, con un casete de expresión insertado seleccionado de SEQ ID Nº 1, SEQ ID Nº 2, SEQ ID Nº 3. En otra forma de realización, el agente contiene, como único componente activo, un vector de expresión basado en el genoma de la cepa recombinante del adenovirus humano de serotipo 5, en el que están eliminadas las regiones E1 y E3, con un casete de expresión insertado seleccionado de SEQ ID Nº 1, SEQ ID Nº 2, SEQ ID Nº 3. En otra forma de realización, el agente contiene como único componente activo un vector de expresión basado en el genoma de la cepa recombinante del adenovirus de simio de serotipo 25, en el que están eliminadas las regiones E1 y E3, con casete de expresión incorporado seleccionado de SEQ ID Nº 4, SEQ ID Nº 2, SEQ ID Nº 3. En este caso, en el caso particular de su implementación, la solución buffer de los medios para la forma líquida contiene, en % en masa: tris de 0,1831 a 0,3432, cloruro de sodio de 0,3313 a 0,6212, sacarosa de 3,7821 a 7,0915, hexahidrato de cloruro de magnesio de 0,0154 a 0,0289, EDTA de 0,0029 a 0,0054, polisorbato-80 de 0,0378 a 0,0709, etanol 95% de 0,0004 a 0,0007, y agua es el resto. El producto está destinado a la administración intranasal o intramuscular. Además, el agente se puede administrar conjuntamente y simultáneamente por vía intranasal e intramuscular. Efecto: El agente propuesto puede utilizarse para la prevención de enfermedades causadas por el virus SARS-CoV-2 del síndrome respiratorio agudo severo, proporcionando una inducción efectiva de una respuesta inmune contra el virus SARS-CoV-2 en la población general.
ARP220100254A 2021-02-09 2022-02-08 AGENTE PARA INDUCIR INMUNIDAD ESPECÍFICA CONTRA EL VIRUS DEL SÍNDROME RESPIRATORIO AGUDO SEVERO SARS-CoV-2 EN FORMA LÍQUIDA (VARIANTES) AR126626A1 (es)

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Application Number Priority Date Filing Date Title
RU2021103099A RU2743963C1 (ru) 2021-02-09 2021-02-09 Средство для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 в жидкой форме (варианты)

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AR126626A1 true AR126626A1 (es) 2023-11-01

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US (1) US20220259618A1 (es)
EP (1) EP4013881A4 (es)
JP (1) JP2023501869A (es)
KR (1) KR20220115554A (es)
CN (1) CN115210378A (es)
AR (1) AR126626A1 (es)
BR (1) BR112022004767A2 (es)
CA (1) CA3156263A1 (es)
IL (1) IL291334A (es)
MX (1) MX2022003069A (es)
RU (1) RU2743963C1 (es)
WO (1) WO2022086365A1 (es)
ZA (1) ZA202202986B (es)

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CN113308493A (zh) * 2021-03-18 2021-08-27 广州恩宝生物医药科技有限公司 新型冠状病毒Ad26腺病毒载体疫苗及其制备方法与应用
US20220356212A1 (en) * 2021-03-26 2022-11-10 Nanogen Pharmaceutical Biotechnology JSC Modified spike protein and method of treatment
RU2761904C1 (ru) * 2021-11-26 2021-12-13 федеральное государственное бюджетное учреждение «Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи» Министерства здравоохранения Российской Федерации Применение средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 у детей
CN115976078B (zh) * 2022-12-30 2023-08-15 广州恩宝生物医药科技有限公司 一种广谱的腺病毒载体新冠疫苗

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MX2021014525A (es) * 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
CN110974950B (zh) * 2020-03-05 2020-08-07 广州恩宝生物医药科技有限公司 一种用于预防SARS-CoV-2感染的腺病毒载体疫苗
CN111217917B (zh) * 2020-02-26 2020-10-23 康希诺生物股份公司 一种新型冠状病毒SARS-CoV-2疫苗及其制备方法
RU2733834C1 (ru) * 2020-07-28 2020-10-07 Федеральное бюджетное учреждение науки Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Искусственный ген EctoS_SC2, кодирующий эктодомен гликопротеина S коронавируса SARS-CoV-2 с C-концевым тримеризующим доменом, рекомбинантная плазмида pStem-rVSV-EctoS_SC2, обеспечивающая экспрессию искусственного гена, и рекомбинантный штамм вируса везикулярного стоматита rVSV-EctoS_SC2, используемый для создания вакцины против коронавируса SARS-CoV-2
RU2731356C9 (ru) * 2020-08-22 2021-10-05 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)
RU2731342C9 (ru) * 2020-08-22 2021-10-05 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Фармацевтическое средство и способ его использования для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)

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