AR126257A1 - Anticuerpo monoclonal anti-ox40 y métodos para su uso - Google Patents
Anticuerpo monoclonal anti-ox40 y métodos para su usoInfo
- Publication number
- AR126257A1 AR126257A1 ARP220101683A ARP220101683A AR126257A1 AR 126257 A1 AR126257 A1 AR 126257A1 AR P220101683 A ARP220101683 A AR P220101683A AR P220101683 A ARP220101683 A AR P220101683A AR 126257 A1 AR126257 A1 AR 126257A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- monoclonal antibody
- antigen
- binding fragment
- cell
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000000427 antigen Substances 0.000 abstract 9
- 102000036639 antigens Human genes 0.000 abstract 9
- 108091007433 antigens Proteins 0.000 abstract 9
- 239000012634 fragment Substances 0.000 abstract 9
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 abstract 5
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 5
- 102000040430 polynucleotide Human genes 0.000 abstract 5
- 108091033319 polynucleotide Proteins 0.000 abstract 5
- 239000002157 polynucleotide Substances 0.000 abstract 5
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- 239000000556 agonist Substances 0.000 abstract 3
- 239000000611 antibody drug conjugate Substances 0.000 abstract 3
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 abstract 2
- 239000012636 effector Substances 0.000 abstract 2
- 102000050320 human TNFRSF4 Human genes 0.000 abstract 2
- 210000003289 regulatory T cell Anatomy 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000003915 cell function Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 210000003162 effector t lymphocyte Anatomy 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 210000003071 memory t lymphocyte Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un nuevo anticuerpo anti-OX40, que incluye las composiciones del anticuerpo anti-OX40, un polinucleótido que codifica el anticuerpo anti-OX40, métodos para preparar el anticuerpo anti-OX40 y métodos para usar el anticuerpo anti-OX40. Reivindicación 1: Un anticuerpo monoclonal aislado, o fragmento de unión al antígeno de este, caracterizado porque dicho anticuerpo monoclonal o fragmento de unión al antígeno de este se une específicamente a OX40 (por ejemplo, OX40 humano) en un epítopo que comprende, consiste esencialmente, o consiste en la SEQ ID Nº 34, como un agonista de OX40, y no afecta sustancialmente la interacción/unión de OX40-OX40L. Reivindicación 20: Un conjugado de anticuerpo-fármaco (ADC), caracterizado porque comprende el anticuerpo monoclonal o fragmento de unión al antígeno de este de cualquiera de las reivindicaciones 1 - 17, y un resto terapéutico, opcionalmente, dicho anticuerpo monoclonal o fragmento de unión al antígeno de este se fusiona a dicho resto terapéutico que es una proteína. Reivindicación 21: Un polinucleótido caracterizado porque codifica el anticuerpo monoclonal o fragmento de unión al antígeno de este de cualquiera de las reivindicaciones 1 - 19. Reivindicación 24: Un vector (tal como un vector de expresión para la expresión en mamíferos) caracterizado porque comprende el polinucleótido de cualquiera de las reivindicaciones 21 - 23. Reivindicación 25: Una célula hospedadora caracterizada porque comprende el polinucleótido de cualquiera de las reivindicaciones 21 - 23, o el vector de la reivindicación 24. Reivindicación 26: Un método para producir el anticuerpo monoclonal o fragmento de unión al antígeno de este de cualquiera de las reivindicaciones 1 - 19, caracterizado porque el método comprende cultivar la célula hospedadora de la reivindicación 25 en un medio en condiciones adecuadas para la expresión de anticuerpos en dicha célula hospedadora, que comprende opcionalmente además recolectar, recolectar, aislar o purificar dicho anticuerpo monoclonal o fragmento de unión al antígeno de este del medio. Reivindicación 27: Una composición farmacéutica caracterizada porque comprende el anticuerpo monoclonal o fragmento de unión al antígeno de este de cualquiera de las reivindicaciones 1 - 19, el ADC de la reivindicación 20, el polinucleótido de cualquiera de las reivindicaciones 21 - 23, o el vector de la reivindicación 24; y un portador o excipiente farmacéuticamente aceptable. Reivindicación 36: Un método para activar un linfocito T (tal como un linfocito T CD4⁺), para inhibir un linfocito Treg, para destruir un linfocito objetivo que expresa OX40, para mejorar la función del linfocito T efector o de memoria, o para reducir la inmunosupresión inducida por el tumor, caracterizado porque comprende poner en contacto el linfocito T, la célula Treg, la célula objetivo que expresa OX40, el linfocito efector o de memoria, respectivamente, con un anticuerpo agonista de OX40, tal como el anticuerpo monoclonal o fragmento de unión al antígeno de este de cualquiera de las reivindicaciones 1 - 19, donde el anticuerpo agonista se une a un epítopo OX40 humano que comprende, consiste esencialmente, o consiste en la secuencia de aminoácidos de la SEQ ID Nº 34.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163216189P | 2021-06-29 | 2021-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR126257A1 true AR126257A1 (es) | 2023-10-04 |
Family
ID=84690770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101683A AR126257A1 (es) | 2021-06-29 | 2022-06-28 | Anticuerpo monoclonal anti-ox40 y métodos para su uso |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4363451A1 (es) |
| KR (1) | KR20240038722A (es) |
| AR (1) | AR126257A1 (es) |
| AU (1) | AU2022305518A1 (es) |
| CA (1) | CA3223942A1 (es) |
| TW (1) | TW202317629A (es) |
| WO (1) | WO2023275616A1 (es) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116092D0 (en) * | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| TW201619200A (zh) * | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | 人類化抗－ｏｘ４０抗體及其用途 |
| US20220017629A1 (en) * | 2018-11-20 | 2022-01-20 | Shanghai Pharmaexplorer Co., Ltd. | Ox40 antibody, preparation method thereof and use thereof |
| CN110003338B (zh) * | 2019-04-16 | 2021-04-23 | 北京免疫方舟医药科技有限公司 | 抗ox40抗体及其应用 |
| CN113045655A (zh) * | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| CN112794907B (zh) * | 2020-12-03 | 2022-09-06 | 安徽安科生物工程（集团）股份有限公司 | 一株全人源抗人huOX40单克隆抗体 |
-
2022
- 2022-06-28 AR ARP220101683A patent/AR126257A1/es unknown
- 2022-06-28 CA CA3223942A patent/CA3223942A1/en active Pending
- 2022-06-28 WO PCT/IB2022/000372 patent/WO2023275616A1/en active Application Filing
- 2022-06-28 TW TW111124135A patent/TW202317629A/zh unknown
- 2022-06-28 KR KR1020247003330A patent/KR20240038722A/ko unknown
- 2022-06-28 AU AU2022305518A patent/AU2022305518A1/en active Pending
- 2022-06-28 EP EP22832263.2A patent/EP4363451A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3223942A1 (en) | 2023-01-05 |
| TW202317629A (zh) | 2023-05-01 |
| AU2022305518A1 (en) | 2024-01-18 |
| EP4363451A1 (en) | 2024-05-08 |
| KR20240038722A (ko) | 2024-03-25 |
| WO2023275616A1 (en) | 2023-01-05 |
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