AR123965A1 - Proceso de purificación de pleuromutilinas - Google Patents

Proceso de purificación de pleuromutilinas

Info

Publication number
AR123965A1
AR123965A1 ARP210103020A ARP210103020A AR123965A1 AR 123965 A1 AR123965 A1 AR 123965A1 AR P210103020 A ARP210103020 A AR P210103020A AR P210103020 A ARP210103020 A AR P210103020A AR 123965 A1 AR123965 A1 AR 123965A1
Authority
AR
Argentina
Prior art keywords
compound
formula
ppm
composition
salt
Prior art date
Application number
ARP210103020A
Other languages
English (en)
Inventor
Larry Pierce
Original Assignee
Elanco Tiergesundheit Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Tiergesundheit Ag filed Critical Elanco Tiergesundheit Ag
Publication of AR123965A1 publication Critical patent/AR123965A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/08—Purification; Separation; Stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C07D303/17—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals containing oxirane rings condensed with carbocyclic ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/84—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing rings with more than eight members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Reivindicación 1: Un proceso para purificar un compuesto de la clase de pleuromutilinas, donde el proceso comprende tratar una composición que comprende una pleuromutilina y una o más impurezas con un nucleófilo en presencia de un solvente para generar una composición que comprende pleuromutilina y uno o más aductos de reacción de impureza-nucleófilo. Reivindicación 10: Una composición que comprende pleuromutilina o una sal de ella, que contiene £ 0,5% (5000 ppm) del compuesto de fórmula (1), preferiblemente £ 0,1% (1000 ppm) del compuesto de fórmula (1), más preferiblemente £ 0,05% (500 ppm) del compuesto de fórmula (1), incluso más preferiblemente £ 0,01% (100 ppm) del compuesto de fórmula (1). Reivindicación 11: Una composición que comprende tiamulina o una sal de ella, que contiene £ 0,5% (5000 ppm) del compuesto de fórmula (2), preferiblemente £ 0,1% (1000 ppm) del compuesto de fórmula (2), más preferiblemente £ 0,05% (500 ppm) del compuesto de fórmula (2), incluso más preferiblemente £ 0,01% (100 ppm) del compuesto de fórmula (2). Reivindicación 13: Una composición que comprende pleuromutilina y al menos un compuesto seleccionado del grupo que consiste en grupo de fórmulas (3). Reivindicación 16: Un método para purificar tiamulina o una sal de ella a partir de un compuesto de fórmula (2), comprendiendo el método: (i) proporcionar una composición que comprende tiamulina o una sal de ella y el compuesto de fórmula (2); (ii) abrir el epóxido de fórmula (2) con un nucleófilo para proporcionar uno o más aductos de reacción; y (iii) separar la tiamulina o una sal de ella del uno o más aductos de reacción.
ARP210103020A 2020-10-29 2021-10-29 Proceso de purificación de pleuromutilinas AR123965A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063106920P 2020-10-29 2020-10-29

Publications (1)

Publication Number Publication Date
AR123965A1 true AR123965A1 (es) 2023-01-25

Family

ID=81383263

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210103020A AR123965A1 (es) 2020-10-29 2021-10-29 Proceso de purificación de pleuromutilinas

Country Status (13)

Country Link
US (1) US20230265040A1 (es)
EP (1) EP4237403A4 (es)
JP (1) JP2023548968A (es)
KR (1) KR20230098233A (es)
CN (1) CN117480151A (es)
AR (1) AR123965A1 (es)
AU (1) AU2021369809A1 (es)
BR (1) BR112023005850A2 (es)
CA (1) CA3195311A1 (es)
CL (1) CL2023001137A1 (es)
MX (1) MX2023004950A (es)
TW (1) TW202233562A (es)
WO (1) WO2022094247A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116199690B (zh) * 2023-04-28 2023-07-07 西华大学 嘌呤类截短侧耳素衍生物、立体异构体或药学上可接受的盐及其用途和药物组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103450061B (zh) * 2012-05-29 2014-10-22 大英九合生物化工股份有限公司 一种工业生产中泰妙菌素反应液的纯化方法
CN109152932B (zh) * 2016-03-02 2021-09-28 比尔及梅琳达盖茨基金会 含硼小分子
US20190352262A1 (en) * 2017-02-01 2019-11-21 Yale University New Pleuromutilin Antibiotic Compounds, Compositions and Methods of Use and Synthesis
TWI762573B (zh) * 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化

Also Published As

Publication number Publication date
CL2023001137A1 (es) 2023-11-24
CN117480151A (zh) 2024-01-30
MX2023004950A (es) 2023-05-17
BR112023005850A2 (pt) 2023-05-09
JP2023548968A (ja) 2023-11-21
AU2021369809A9 (en) 2024-10-03
CA3195311A1 (en) 2022-05-05
EP4237403A4 (en) 2024-09-18
KR20230098233A (ko) 2023-07-03
AU2021369809A1 (en) 2023-05-11
WO2022094247A1 (en) 2022-05-05
EP4237403A1 (en) 2023-09-06
US20230265040A1 (en) 2023-08-24
TW202233562A (zh) 2022-09-01

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