AR121654A1 - Proceso para la preparación de ácido (r)-4-(1-(6-(4-(trifluorometil)bencil)-6-azaspiro[2.5]octano-5-carboxamido)-ciclopropil)benzoico o una sal del mismo - Google Patents

Proceso para la preparación de ácido (r)-4-(1-(6-(4-(trifluorometil)bencil)-6-azaspiro[2.5]octano-5-carboxamido)-ciclopropil)benzoico o una sal del mismo

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Publication number
AR121654A1
AR121654A1 ARP210100737A ARP210100737A AR121654A1 AR 121654 A1 AR121654 A1 AR 121654A1 AR P210100737 A ARP210100737 A AR P210100737A AR P210100737 A ARP210100737 A AR P210100737A AR 121654 A1 AR121654 A1 AR 121654A1
Authority
AR
Argentina
Prior art keywords
formula
compound
octane
azaspyro
trifluomethyl
Prior art date
Application number
ARP210100737A
Other languages
English (en)
Inventor
Lucio Claudio Rovati
Roberto Artusi
Filippo Magaraci
Benedetta Buzzi
Original Assignee
Rottapharm Biotech S R L Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm Biotech S R L Llc filed Critical Rottapharm Biotech S R L Llc
Publication of AR121654A1 publication Critical patent/AR121654A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un proceso para preparar ácido (R)-6-(terc-butoxicarbonil)-6-azaespiro[2.5]octano-5-carboxílico de fórmula (1) dicho proceso comprende el paso de: iv) convertir un compuesto de fórmula (2) en un compuesto de fórmula (3) utilizando un reactivo de Wittig en un disolvente adecuado; v) hacer reaccionar a través de la reacción de Makosza el compuesto de fórmula (3) usando bromoformo y una base adecuada para obtener el compuesto de ciclopropano de fórmula (4) y; vi) eliminar átomos de bromo en presencia de un agente reductor y una base en un disolvente alcohólico obteniendo así el compuesto de fórmula (1).
ARP210100737A 2020-03-27 2021-03-25 Proceso para la preparación de ácido (r)-4-(1-(6-(4-(trifluorometil)bencil)-6-azaspiro[2.5]octano-5-carboxamido)-ciclopropil)benzoico o una sal del mismo AR121654A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20166480.2A EP3885339A1 (en) 2020-03-27 2020-03-27 Process for the preparation of (r)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)-cyclopropyl) benzoic acid or a salt thereof

Publications (1)

Publication Number Publication Date
AR121654A1 true AR121654A1 (es) 2022-06-29

Family

ID=70057038

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210100737A AR121654A1 (es) 2020-03-27 2021-03-25 Proceso para la preparación de ácido (r)-4-(1-(6-(4-(trifluorometil)bencil)-6-azaspiro[2.5]octano-5-carboxamido)-ciclopropil)benzoico o una sal del mismo

Country Status (11)

Country Link
US (1) US20230127805A1 (es)
EP (2) EP3885339A1 (es)
JP (1) JP2023519231A (es)
KR (1) KR20220160031A (es)
CN (1) CN115515936A (es)
AR (1) AR121654A1 (es)
AU (1) AU2021245014A1 (es)
BR (1) BR112022019285A2 (es)
CA (1) CA3172903A1 (es)
TW (1) TW202140423A (es)
WO (1) WO2021191062A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114380717A (zh) * 2022-01-28 2022-04-22 郑州猫眼农业科技有限公司 3-(叔丁氧基羰基-甲氧基羰基甲基-氨基)-丙酸甲酯及其中间体的制备方法
CN116143695B (zh) * 2023-02-17 2024-04-05 上海麦克林生化科技股份有限公司 一种1,1-二氟-5-氮杂螺[2.5]辛烷盐酸盐的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2114877B1 (en) 2007-02-26 2012-12-26 Merck Canada Inc. Indole and indoline cyclopropyl amide derivatives as ep4 receptor antagonists
KR101667063B1 (ko) * 2008-09-02 2016-10-17 닛산 가가쿠 고교 가부시키 가이샤 오르토 치환 할로알킬술폰아닐리드 유도체 및 제초제
EP2484674A1 (en) * 2011-02-02 2012-08-08 Rottapharm S.P.A. Spiro aminic compounds with NK1 antagonist activity
PL2729445T3 (pl) * 2011-07-04 2016-04-29 Rottapharm Biotech Srl Cykliczne pochodne aminowe jako antagoniści receptora EP4
ITMI20112329A1 (it) * 2011-12-21 2013-06-22 Rottapharm Spa Nuovi derivati spiro amminici
US9056860B2 (en) * 2012-06-05 2015-06-16 Gilead Pharmasset Llc Synthesis of antiviral compound
AU2014366361B2 (en) * 2013-12-17 2017-04-20 Eli Lilly And Company Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators
CN106928127B (zh) * 2015-12-31 2021-07-16 四川海思科制药有限公司 取代哌啶类酰胺衍生物及其制备方法和在药学上的应用
CN107954990A (zh) * 2017-11-14 2018-04-24 安徽诺全药业有限公司 一种雷迪帕维的制备方法

Also Published As

Publication number Publication date
WO2021191062A1 (en) 2021-09-30
JP2023519231A (ja) 2023-05-10
EP3885339A1 (en) 2021-09-29
AU2021245014A1 (en) 2022-10-27
US20230127805A1 (en) 2023-04-27
TW202140423A (zh) 2021-11-01
BR112022019285A2 (pt) 2022-11-16
KR20220160031A (ko) 2022-12-05
CA3172903A1 (en) 2021-09-30
EP4126821B1 (en) 2024-05-15
EP4126821A1 (en) 2023-02-08
CN115515936A (zh) 2022-12-23

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