AR121546A1 - Constructos y composiciones de wpre mutante y sus métodos - Google Patents

Constructos y composiciones de wpre mutante y sus métodos

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Publication number
AR121546A1
AR121546A1 ARP210100613A ARP210100613A AR121546A1 AR 121546 A1 AR121546 A1 AR 121546A1 AR P210100613 A ARP210100613 A AR P210100613A AR P210100613 A ARP210100613 A AR P210100613A AR 121546 A1 AR121546 A1 AR 121546A1
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AR
Argentina
Prior art keywords
methods
constructs
compositions
wpre
present
Prior art date
Application number
ARP210100613A
Other languages
English (en)
Inventor
Melinda Mata
Mamta Kalra
Steffen Walter
Ali Mohamed
Yannick Bulliard
Original Assignee
Immatics Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Us Inc filed Critical Immatics Us Inc
Publication of AR121546A1 publication Critical patent/AR121546A1/es

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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona un elemento regulador postranscripcional de la marmota (WPRE, woodchuck post-transcriptional regulatory element) mutado. En particular, la presente invención se relaciona con una secuencia WPRE mutada que puede expresar eficientemente nucleótidos de interés en un sistema de vectores retrovíricos. La presente invención también se relaciona con métodos de administrar y expresar nucleótidos de interés a una célula objetivo.
ARP210100613A 2020-03-11 2021-03-11 Constructos y composiciones de wpre mutante y sus métodos AR121546A1 (es)

Applications Claiming Priority (1)

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US202062988202P 2020-03-11 2020-03-11

Publications (1)

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AR121546A1 true AR121546A1 (es) 2022-06-15

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ID=75278397

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ARP210100613A AR121546A1 (es) 2020-03-11 2021-03-11 Constructos y composiciones de wpre mutante y sus métodos

Country Status (9)

Country Link
US (2) US11851673B2 (es)
EP (1) EP4118218A1 (es)
JP (1) JP2023517940A (es)
KR (1) KR20230015313A (es)
CN (1) CN115667535A (es)
AR (1) AR121546A1 (es)
DE (1) DE102020111571A1 (es)
TW (1) TW202200789A (es)
WO (1) WO2021183643A1 (es)

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US20240150790A1 (en) 2024-05-09
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