AR119549A1 - Agente de reclutamiento que adicionalmente se une a una molécula del mhc - Google Patents
Agente de reclutamiento que adicionalmente se une a una molécula del mhcInfo
- Publication number
- AR119549A1 AR119549A1 ARP200102162A ARP200102162A AR119549A1 AR 119549 A1 AR119549 A1 AR 119549A1 AR P200102162 A ARP200102162 A AR P200102162A AR P200102162 A ARP200102162 A AR P200102162A AR 119549 A1 AR119549 A1 AR 119549A1
- Authority
- AR
- Argentina
- Prior art keywords
- antigen
- binding proteins
- binding
- binds
- bispecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente concierne a proteínas de unión a antígeno biespecíficas que están dirigidas contra antígenos diana (AD) que son presentados por el MHC. La misma proporciona en particular proteínas de unión a antígeno biespecíficas que comprenden al menos dos sitios de unión a antígeno (A y B), en las cuales el sitio de unión a antígeno A se une al CD3 y el sitio de unión a antígeno B se une a un complejo formado por el péptido antigénico diana y el MHC. Las proteínas de unión a antígeno biespecíficas de la presente comprenden, en particular, las CDR de los dominios VH y VL de anticuerpos genomodificados anti-CD3 dotados de una afinidad reducida. Las proteínas de unión a antígeno biespecíficas de la presente están destinadas al uso en el diagnóstico, el tratamiento y la prevención de enfermedades asociadas a AD, como las enfermedades cancerosas que expresan antígenos asociados a tumores (AAT). Además, se proporcionan ácidos nucleicos que codifican las proteínas de unión a antígeno biespecíficas de la misma, los vectores que comprenden esos ácidos nucleicos, las células recombinantes que expresan la proteína de unión de antígeno y las composiciones farmacéuticas que comprenden las proteínas de unión a antígeno biespecíficas de la presente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102019121022.4A DE102019121022A1 (de) | 2019-08-02 | 2019-08-02 | Rekrutierungsagens, das zusätzlich ein MHC-Molekül bindet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR119549A1 true AR119549A1 (es) | 2021-12-29 |
Family
ID=74495302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200102162A AR119549A1 (es) | 2019-08-02 | 2020-07-31 | Agente de reclutamiento que adicionalmente se une a una molécula del mhc |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR119549A1 (es) |
| DE (1) | DE102019121022A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115838432B (zh) * | 2022-07-08 | 2023-12-08 | 浙江大学 | 一种靶向调控抗原特异性t细胞的融合蛋白及应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102017115966A1 (de) * | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
-
2019
- 2019-08-02 DE DE102019121022.4A patent/DE102019121022A1/de active Pending
-
2020
- 2020-07-31 AR ARP200102162A patent/AR119549A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE102019121022A1 (de) | 2021-02-25 |
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