AR118302A1 - Compuestos disulfuro y composiciones que comprenden los mismos para tratar hipertensión o fallo cardíaco - Google Patents
Compuestos disulfuro y composiciones que comprenden los mismos para tratar hipertensión o fallo cardíacoInfo
- Publication number
- AR118302A1 AR118302A1 ARP200100650A ARP200100650A AR118302A1 AR 118302 A1 AR118302 A1 AR 118302A1 AR P200100650 A ARP200100650 A AR P200100650A AR P200100650 A ARP200100650 A AR P200100650A AR 118302 A1 AR118302 A1 AR 118302A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- aryl
- cycloalkyl
- arylalkyl
- heart failure
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 206010020772 Hypertension Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000002019 disulfides Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se proveen compuestos disulfuro, una composición farmacéutica que los comprende y su uso en el tratamiento de trastornos directa o indirectamente relacionados con hipertensión arterial tales como fallo cardíaco, insuficiencia cardíaca, glaucoma y enfermedades neurodegenerativas entre otras. Reivindicación 1: Un compuesto que tiene la fórmula (1) y más específicamente que tiene la fórmula (2) en donde: AH representa -CO₂H, -SO₃H, -PO₃H₂; m es 1, 2 ó 3; R¹ y R² representan independientemente H, un grupo alquilo C₁₋₆, alquenilo C₂₋₆ o alquinilo C₂₋₆, estando cada grupo alquilo, alquenilo o alquinilo opcionalmente sustituido con al menos uno de los siguientes radicales elegidos de un grupo arilo, heterociclo, cicloalquilo, O-arilo, O-arilalquilo o O-cicloalquilo; estando dicho grupo arilo, heterociclo, cicloalquilo, O-arilo, O-arilalquilo, O-cicloalquilo opcionalmente sustituido con uno o más radicales elegidos de un átomo de halógeno, un grupo alquilo, un grupo alcoxi, un grupo haloalquilo, un grupo haloalcoxi, un grupo acilo, un grupo O-cicloalquilo, un grupo heteroalquilo, un grupo O-arilo, un grupo O-arilalquilo, un grupo arilo, un grupo heterociclo o un grupo arilalquilo; una sal, solvato, forma zwitteriónica o cualquier prodroga del mismo, farmacéuticos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19305286 | 2019-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR118302A1 true AR118302A1 (es) | 2021-09-29 |
Family
ID=65818483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200100650A AR118302A1 (es) | 2019-03-11 | 2020-03-10 | Compuestos disulfuro y composiciones que comprenden los mismos para tratar hipertensión o fallo cardíaco |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11345658B2 (es) |
| EP (1) | EP3937924B1 (es) |
| JP (1) | JP2022520494A (es) |
| KR (1) | KR102401407B1 (es) |
| CN (1) | CN113784710A (es) |
| AR (1) | AR118302A1 (es) |
| AU (1) | AU2020235216B2 (es) |
| BR (1) | BR112021017158A2 (es) |
| CA (1) | CA3129677C (es) |
| EA (1) | EA202192421A1 (es) |
| ES (1) | ES2965293T3 (es) |
| IL (1) | IL285593B (es) |
| MA (1) | MA55275A (es) |
| MX (1) | MX2021011041A (es) |
| TW (1) | TW202100146A (es) |
| WO (1) | WO2020182870A1 (es) |
| ZA (1) | ZA202107513B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112142629B (zh) * | 2020-10-10 | 2021-09-14 | 西北工业大学 | 3-氨基磺酰基丙氨酸的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773712B1 (fr) | 1998-01-16 | 2000-06-02 | Inst Nat Sante Rech Med | Composition pharmaceutique comprenant au moins un inhibiteur de l'aminopeptidase a |
| FR2858617A1 (fr) * | 2003-08-06 | 2005-02-11 | Inst Nat Sante Rech Med | Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant |
| EP2439192A1 (en) | 2010-10-07 | 2012-04-11 | Quantum Genomics | Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) |
-
2020
- 2020-03-09 TW TW109107735A patent/TW202100146A/zh unknown
- 2020-03-10 AR ARP200100650A patent/AR118302A1/es unknown
- 2020-03-11 CA CA3129677A patent/CA3129677C/en active Active
- 2020-03-11 AU AU2020235216A patent/AU2020235216B2/en not_active Ceased
- 2020-03-11 EP EP20708139.9A patent/EP3937924B1/en active Active
- 2020-03-11 ES ES20708139T patent/ES2965293T3/es active Active
- 2020-03-11 IL IL285593A patent/IL285593B/en unknown
- 2020-03-11 CN CN202080020321.1A patent/CN113784710A/zh active Pending
- 2020-03-11 MA MA055275A patent/MA55275A/fr unknown
- 2020-03-11 EA EA202192421A patent/EA202192421A1/ru unknown
- 2020-03-11 JP JP2021554368A patent/JP2022520494A/ja active Pending
- 2020-03-11 WO PCT/EP2020/056483 patent/WO2020182870A1/en unknown
- 2020-03-11 MX MX2021011041A patent/MX2021011041A/es unknown
- 2020-03-11 BR BR112021017158A patent/BR112021017158A2/pt not_active Application Discontinuation
- 2020-03-11 KR KR1020217032594A patent/KR102401407B1/ko active IP Right Grant
- 2020-03-11 US US17/437,862 patent/US11345658B2/en active Active
-
2021
- 2021-10-06 ZA ZA2021/07513A patent/ZA202107513B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA202192421A1 (ru) | 2021-12-22 |
| AU2020235216A1 (en) | 2021-09-09 |
| US20220041548A1 (en) | 2022-02-10 |
| MX2021011041A (es) | 2021-10-13 |
| CA3129677C (en) | 2023-01-03 |
| CN113784710A (zh) | 2021-12-10 |
| TW202100146A (zh) | 2021-01-01 |
| CA3129677A1 (en) | 2020-09-17 |
| BR112021017158A2 (pt) | 2021-11-09 |
| KR20210134037A (ko) | 2021-11-08 |
| US11345658B2 (en) | 2022-05-31 |
| WO2020182870A1 (en) | 2020-09-17 |
| EP3937924B1 (en) | 2023-09-06 |
| IL285593B (en) | 2022-07-01 |
| AU2020235216B2 (en) | 2021-12-16 |
| IL285593A (en) | 2021-09-30 |
| ZA202107513B (en) | 2023-01-25 |
| EP3937924A1 (en) | 2022-01-19 |
| MA55275A (fr) | 2022-01-19 |
| ES2965293T3 (es) | 2024-04-12 |
| KR102401407B1 (ko) | 2022-05-23 |
| JP2022520494A (ja) | 2022-03-30 |
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