AR117006A1 - Compuesto de 1,3-azol sustituido, composición farmacéutica que lo comprende y su uso para la fabricación de un medicamento - Google Patents
Compuesto de 1,3-azol sustituido, composición farmacéutica que lo comprende y su uso para la fabricación de un medicamentoInfo
- Publication number
- AR117006A1 AR117006A1 ARP190103251A ARP190103251A AR117006A1 AR 117006 A1 AR117006 A1 AR 117006A1 AR P190103251 A ARP190103251 A AR P190103251A AR P190103251 A ARP190103251 A AR P190103251A AR 117006 A1 AR117006 A1 AR 117006A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluoro
- independently selected
- substituents independently
- substituted
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
- C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
- C07D421/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula (1) en donde Ar¹, R²¹, R²³, R²⁴, R²⁵, R²⁶, R²⁷, A, X, Y y W son como se definen en el presente documento. Los compuestos de la presente son inhibidores de prostaglandina D sintasa hematopoyética (H-PGDS) y pueden ser útiles en el tratamiento de distrofia muscular de Duchenne. Por consiguiente, la presente se refiere además a composiciones farmacéuticas que comprenden un compuesto de la misma. La presente también se refiere además a métodos para inhibir la actividad de H-PGDS y tratamiento de trastornos asociados a la misma usando un compuesto de la presente o una composición farmacéutica que comprende un compuesto de la presente. Reivindicación 1: Un compuesto de 1,3-azol sustituido caracterizado porque tiene la fórmula (1), en donde: Ar¹ se selecciona entre: fenilo, benzofuranilo, pirazolilo, imidazolilo, piridinilo, y pirimidinilo, cada uno de los cuales está opcionalmente sustituido con 1 a 4 sustituyentes seleccionados independientemente entre: fluoro, cloro, bromo, yodo, alquilo C₁₋₃, alquilo C₁₋₃ sustituido con uno a cuatro sustituyentes seleccionados independientemente entre: -OH, oxo y fluoro, -CN, -OH, ciclopropilo, alcoxi C₁₋₃, y alcoxi C₁₋₃ sustituido con uno a cuatro sustituyentes seleccionados independientemente entre: -OH, oxo y fluoro; W se selecciona entre: S y Se; X se selecciona entre: C y N; Y se selecciona entre: -C(O)-, -C(S)-, -C(Se)-, -S(O)- y -S(O₂)-; A se selecciona entre: -C(O)-, -C(S)-, -C(Se)- y -S(O₂)-; R²¹ se selecciona entre: hidrógeno y -CH₃; R²³ y R²⁴ están unidos a átomos de carbono iguales o diferentes y se seleccionan independientemente entre: hidrógeno, alquilo C₁₋₅, alquilo C₁₋₅ sustituido con uno o cuatro sustituyentes independientemente seleccionados entre: -OH, oxo, -NH₂ y fluoro, o R²³ y R²⁴ están unidos al mismo carbono y se toman juntos para formar: ciclopropilo, ciclobutilo, ciclopentilo, oxetanilo, tetrahidrofurano, o tetrahidropirano, o R²³ y R²⁴ están unidos a diferentes átomos de carbono y se toman juntos para formar: ciclopropilo, ciclobutilo, ciclopentilo, oxetanilo, tetrahidrofurano, o tetrahidropirano; R²⁵ se selecciona entre: hidrógeno, alquilo C₁₋₅, alquilo C₁₋₅ sustituido con uno a cuatro sustituyentes independientemente seleccionados entre: -OH, oxo, -NH₂ y fluoro, y alquilarilo C₁₋₅, y alquilarilo C₁₋₅ sustituido con 1 a 3 sustituyentes independientemente seleccionados entre fluoro, cloro, bromo, yodo, alquilo C₁₋₃, alquilo C₁₋₃ sustituido con uno a cuatro sustituyentes independientemente seleccionados entre: -OH, oxo y fluoro, -CN, -OH, ciclopropilo, alcoxi C₁₋₃, y alcoxi C₁₋₃ sustituido con uno a cuatro sustituyentes independientemente seleccionados entre: -OH, oxo y fluoro; R²⁶ se selecciona entre: hidrógeno y -CH₃; y R²⁷ está ausente cuando X es N o se selecciona entre: hidrógeno y -CH₃; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862757205P | 2018-11-08 | 2018-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR117006A1 true AR117006A1 (es) | 2021-07-07 |
Family
ID=68542702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190103251A AR117006A1 (es) | 2018-11-08 | 2019-11-06 | Compuesto de 1,3-azol sustituido, composición farmacéutica que lo comprende y su uso para la fabricación de un medicamento |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220009918A1 (es) |
EP (1) | EP3877384A1 (es) |
JP (1) | JP2022506850A (es) |
CN (1) | CN112969698A (es) |
AR (1) | AR117006A1 (es) |
BR (1) | BR112021008976A2 (es) |
CA (1) | CA3117943A1 (es) |
TW (1) | TW202039479A (es) |
UY (1) | UY38455A (es) |
WO (1) | WO2020095215A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115667259A (zh) | 2020-06-19 | 2023-01-31 | 佐藤制药株式会社 | 抑制h-pgds的稠环化合物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
WO2005094805A1 (ja) | 2004-04-01 | 2005-10-13 | Institute Of Medicinal Molecular Design. Inc. | イミン誘導体及びアミド誘導体 |
TW200720255A (en) | 2005-07-13 | 2007-06-01 | Taiho Pharmaceutical Co Ltd | Benzoimidazole compound capable of inhibiting prostaglandin d synthetase |
JP2007051121A (ja) | 2005-07-22 | 2007-03-01 | Taiho Yakuhin Kogyo Kk | プロスタグランジンd合成酵素を阻害するピリミジン化合物 |
PE20110118A1 (es) | 2005-10-04 | 2011-03-08 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
EP2129660A2 (en) | 2006-12-19 | 2009-12-09 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
SG179437A1 (en) | 2007-03-30 | 2012-04-27 | Sanofi Aventis | Pyrimidine hydrazide compounds as pgds inhibitors |
GB0706793D0 (en) | 2007-04-05 | 2007-05-16 | Evotec Ag | Compounds |
US8334314B2 (en) | 2008-04-28 | 2012-12-18 | Asahi Kasei Pharma Corporation | Phenylpropionic acid derivative and use thereof |
CA2722420A1 (en) | 2008-05-13 | 2009-11-19 | Cayman Chemical Company, Incorporated | Methods for assaying compounds or agents for ability to displace potent ligands of hematopoietic prostaglandin d synthase |
CA2724998A1 (en) | 2008-06-18 | 2009-12-23 | Pfizer Limited | Nicotinamide derivatives |
US20110306597A1 (en) | 2008-06-18 | 2011-12-15 | James Michael Crawforth | Nicotinamide Derivatives |
SG2014014013A (en) | 2008-09-22 | 2014-07-30 | Cayman Chemical Co Inc | Multiheteroaryl compounds as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
ES2564454T3 (es) | 2009-03-09 | 2016-03-22 | Taiho Pharmaceutical Co., Ltd. | Compuesto de piperazina que puede inhibir la prostaglandina D sintasa |
WO2011043359A1 (ja) | 2009-10-06 | 2011-04-14 | 協和発酵キリン株式会社 | 芳香族複素環化合物を含有する医薬 |
RU2572608C2 (ru) | 2009-10-08 | 2016-01-20 | Санофи | Производные фенилоксадиазола в качестве ингибиторов pgds |
CA2787248C (en) | 2010-01-22 | 2016-03-01 | Taiho Pharmaceutical Co., Ltd. | Piperazine compound having a pgds inhibitory effect |
TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ep2受體拮抗劑之新穎2h-吲唑 |
CA3066979A1 (en) * | 2017-06-13 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as h-pgds inhibitors |
-
2019
- 2019-11-06 WO PCT/IB2019/059517 patent/WO2020095215A1/en unknown
- 2019-11-06 CA CA3117943A patent/CA3117943A1/en not_active Abandoned
- 2019-11-06 TW TW108140264A patent/TW202039479A/zh unknown
- 2019-11-06 UY UY0001038455A patent/UY38455A/es unknown
- 2019-11-06 EP EP19802295.6A patent/EP3877384A1/en not_active Withdrawn
- 2019-11-06 JP JP2021524462A patent/JP2022506850A/ja active Pending
- 2019-11-06 AR ARP190103251A patent/AR117006A1/es unknown
- 2019-11-06 CN CN201980073830.8A patent/CN112969698A/zh active Pending
- 2019-11-06 US US17/291,087 patent/US20220009918A1/en active Pending
- 2019-11-06 BR BR112021008976-4A patent/BR112021008976A2/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20220009918A1 (en) | 2022-01-13 |
CA3117943A1 (en) | 2020-05-14 |
JP2022506850A (ja) | 2022-01-17 |
UY38455A (es) | 2020-05-29 |
EP3877384A1 (en) | 2021-09-15 |
CN112969698A (zh) | 2021-06-15 |
BR112021008976A2 (pt) | 2021-08-03 |
WO2020095215A1 (en) | 2020-05-14 |
TW202039479A (zh) | 2020-11-01 |
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