AR112837A1 - Métodos de preparación de formas cristalinas de derivados de diazabiciclooctano y composiciones farmacéuticas que las comprenden - Google Patents

Métodos de preparación de formas cristalinas de derivados de diazabiciclooctano y composiciones farmacéuticas que las comprenden

Info

Publication number
AR112837A1
AR112837A1 ARP180102748A ARP180102748A AR112837A1 AR 112837 A1 AR112837 A1 AR 112837A1 AR P180102748 A ARP180102748 A AR P180102748A AR P180102748 A ARP180102748 A AR P180102748A AR 112837 A1 AR112837 A1 AR 112837A1
Authority
AR
Argentina
Prior art keywords
formula
compound
aqueous solution
producing
methods
Prior art date
Application number
ARP180102748A
Other languages
English (en)
Inventor
Frdric Ran
Michael Kammerer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR112837A1 publication Critical patent/AR112837A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente se refiere a un proceso para producir formas cristalinas y amorfas de un derivado de diazabiciclooctano representado por el compuesto de fórmula (1) y métodos para producirlas. Reivindicación 1: Un proceso para producir una forma cristalina IV de un compuesto representado por la fórmula (1), caracterizado porque comprende: (a) disolver el compuesto de fórmula (1) en agua para formar una solución acuosa del compuesto de fórmula (1); (b) añadir la solución acuosa del compuesto de fórmula (1) a un alcohol para formar una suspensión; y (c) recuperar la suspensión para producir la forma cristalina IV del compuesto de fórmula (1). Reivindicación 13: El proceso de acuerdo con la reivindicación 1, caracterizado porque la forma cristalina IV se caracteriza por un patrón de difracción de polvos por rayos X que tiene picos característicos expresados en valores de grados 2q a aproximadamente 11,3; aproximadamente 13,9; y aproximadamente 19,8 ± 0,2. Reivindicación 17: Un proceso para producir una forma amorfa de un compuesto representado por la fórmula (1), caracterizado porque comprende: (a) disolver el compuesto de fórmula (1) en agua para formar una solución acuosa del compuesto de fórmula (1); y (b) evaporar la solución acuosa a presión reducida a una temperatura mayor que temperatura ambiente para producir la forma amorfa del compuesto de fórmula (1).
ARP180102748A 2017-09-27 2018-09-26 Métodos de preparación de formas cristalinas de derivados de diazabiciclooctano y composiciones farmacéuticas que las comprenden AR112837A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762563803P 2017-09-27 2017-09-27

Publications (1)

Publication Number Publication Date
AR112837A1 true AR112837A1 (es) 2019-12-18

Family

ID=64362572

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180102748A AR112837A1 (es) 2017-09-27 2018-09-26 Métodos de preparación de formas cristalinas de derivados de diazabiciclooctano y composiciones farmacéuticas que las comprenden

Country Status (10)

Country Link
US (1) US10584123B2 (es)
EP (1) EP3687993A1 (es)
JP (1) JP7200235B2 (es)
KR (1) KR20200091394A (es)
CN (1) CN111465604B (es)
AR (1) AR112837A1 (es)
CA (1) CA3076949A1 (es)
IL (1) IL273536A (es)
TW (1) TW201920174A (es)
WO (1) WO2019064066A1 (es)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03193735A (ja) 1989-12-22 1991-08-23 Shionogi & Co Ltd グリコペプチド系抗生物質の安定化組成物
DE19903275A1 (de) * 1999-01-28 2000-08-03 Merck Patent Gmbh Lyophilisate mit verbesserter Rekonstituierbarkeit
US7378408B2 (en) 2001-11-30 2008-05-27 Pfizer Inc. Methods of treatment and formulations of cephalosporin
KR20080100264A (ko) * 2006-03-21 2008-11-14 닥터 레디스 레보러터리즈 리미티드 도세탁셀의 다형체와 그 제조방법
CN101264088B (zh) 2008-04-25 2011-11-23 黄芝芳 一种含量稳定、溶解快速的抗菌素组合物
FR2951171A1 (fr) * 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
KR101875720B1 (ko) * 2011-01-10 2018-07-09 인피니티 파마슈티칼스, 인코포레이티드 이소퀴놀린온 및 이의 고체 형태의 제조 방법
CN102351855A (zh) * 2011-08-12 2012-02-15 山西仟源制药股份有限公司 β晶型氨曲南无菌原料药的生产方法
US8796257B2 (en) * 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
ES2758507T3 (es) 2012-05-30 2020-05-05 Meiji Seika Pharma Co Ltd Nuevo inhibidor de B-lactamasa y método para producir el mismo
MX368346B (es) 2012-08-25 2019-09-27 Wockhardt Ltd Derivados de 1,6- diazabiciclo [3.2,1] octano-7-ona y su uso en el tratamiento de las infecciones bacterianas.
US9643950B2 (en) * 2012-10-22 2017-05-09 Concert Pharmaceuticals, Inc. Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidine-3,4,4,5,5-d5)-2,6-dione}
MY176278A (en) 2013-09-24 2020-07-27 Meiji Seika Pharma Co Ltd Process for producing diazabicyclooctane derivative and intermediate thereof
NZ743374A (en) 2013-10-08 2021-12-24 Meiji Seika Pharma Co Ltd Crystalline forms of diazabicyclooctane derivative and production process thereof
MX2017007191A (es) * 2014-12-05 2017-08-28 Meiji Seika Pharma Co Ltd Procedimiento de produccion de cristales de derivado de diazabiciclooctano y preparacion liofilizada estable.
WO2016116878A1 (en) 2015-01-24 2016-07-28 Wockhardt Limited Antibacterial compositions of a beta-lactamase inhibitor with a cephalosporin
WO2016120752A1 (en) 2015-01-28 2016-08-04 Wockhardt Limited A process for preparation of (2s, 5r)-n-(2-amino ethoxy)-6-(sulfooxy)-7-oxo-1,6- diazabicyclo [3.2.1] octane-2-carboxamide
WO2016151543A1 (en) 2015-03-25 2016-09-29 Wockhardt Limited Pharmaceutical compositions comprising antibacterial agents

Also Published As

Publication number Publication date
JP7200235B2 (ja) 2023-01-06
WO2019064066A1 (en) 2019-04-04
KR20200091394A (ko) 2020-07-30
CN111465604B (zh) 2023-05-12
JP2020535210A (ja) 2020-12-03
IL273536A (en) 2020-05-31
CN111465604A (zh) 2020-07-28
US10584123B2 (en) 2020-03-10
TW201920174A (zh) 2019-06-01
EP3687993A1 (en) 2020-08-05
US20190106421A1 (en) 2019-04-11
CA3076949A1 (en) 2019-04-04

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