AR112612A1 - Purificación de conjugados de fármacos-anticuerpos luego del acoplamiento - Google Patents
Purificación de conjugados de fármacos-anticuerpos luego del acoplamientoInfo
- Publication number
- AR112612A1 AR112612A1 ARP180102022A AR112612A1 AR 112612 A1 AR112612 A1 AR 112612A1 AR P180102022 A ARP180102022 A AR P180102022A AR 112612 A1 AR112612 A1 AR 112612A1
- Authority
- AR
- Argentina
- Prior art keywords
- product stream
- capillaries
- ultrafiltration
- purification
- product
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 2
- 230000008878 coupling Effects 0.000 title 1
- 238000010168 coupling process Methods 0.000 title 1
- 238000005859 coupling reaction Methods 0.000 title 1
- 229940127121 immunoconjugate Drugs 0.000 title 1
- 238000000108 ultra-filtration Methods 0.000 abstract 5
- 239000012530 fluid Substances 0.000 abstract 3
- 238000005406 washing Methods 0.000 abstract 2
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/08—Specific process operations in the concentrate stream
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Water Supply & Treatment (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Peptides Or Proteins (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Se describe en la presente una unidad de ultrafiltración y purificación (1) de una corriente de producto (3) que contiene un producto biológico macromolecular así como también una sustancia que se ha de separar de la corriente de producto, que comprende al menos un módulo de ultrafiltración capilar (2), caracterizada porque: al menos una bomba (4) conduce la corriente de producto hacia el interior de los capilares del al menos un módulo de ultrafiltración capilar, al menos una bomba de desplazamiento positivo (5) conduce la corriente de producto desde los capilares, y al menos otra bomba (6) hace pasar un fluido de lavado (9) sobre el exterior de los capilares, la unidad no incluye ninguna medida para la circulación de la corriente de producto y el fluido de lavado hacia el interior del módulo de ultrafiltración, así como también al menos un filtro de protección (8), a través del cual pasa todo el fluido que egresa del al menos un módulo de ultrafiltración capilar en la dirección de la corriente de producto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17182039.2A EP3431168A1 (en) | 2017-07-19 | 2017-07-19 | Élimination de médicament non lié après couplage conjugué anticorps-médicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR112612A1 true AR112612A1 (es) | 2019-11-20 |
Family
ID=59520721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180102022 AR112612A1 (es) | 2017-07-19 | 2018-07-19 | Purificación de conjugados de fármacos-anticuerpos luego del acoplamiento |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20200206688A1 (es) |
| EP (2) | EP3431168A1 (es) |
| JP (1) | JP2020527102A (es) |
| KR (1) | KR20200031134A (es) |
| CN (1) | CN111093810A (es) |
| AR (1) | AR112612A1 (es) |
| AU (1) | AU2018304504A1 (es) |
| BR (1) | BR112020001058A2 (es) |
| CA (1) | CA3070113A1 (es) |
| IL (1) | IL271949A (es) |
| RU (1) | RU2020107296A (es) |
| SG (1) | SG11202000264TA (es) |
| TW (1) | TW201919747A (es) |
| WO (1) | WO2019016070A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7474195B2 (ja) * | 2018-01-12 | 2024-04-24 | イミュノジェン， インコーポレイテッド | 抗体薬物のコンジュゲーション、精製、及び製剤のための方法 |
| EP3939691B1 (en) * | 2020-07-13 | 2023-11-22 | Sartorius Stedim Biotech GmbH | Device assembly for producing bioconjugates |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4670077B2 (ja) * | 2004-10-04 | 2011-04-13 | 独立行政法人産業技術総合研究所 | 生理活性高分子物質の精製方法及びその方法により得られる精製物 |
| IL308456A (en) * | 2005-04-08 | 2024-01-01 | Wyeth Llc | A multivalent pneumomuroral protein-polysaccharide conjugate preparation |
| CN101219846B (zh) * | 2008-01-23 | 2010-12-01 | 哈尔滨工业大学 | 超滤膜混凝/吸附/生物反应器一体化水深度处理方法及其装置 |
| EA025786B1 (ru) * | 2011-03-29 | 2017-01-30 | Иммуноджен, Инк. | Способ производства конъюгатов с улучшенной гомогенностью |
| US9650411B2 (en) * | 2012-08-07 | 2017-05-16 | Kyowa Hakko Kirin Co., Ltd. | Method of purifying protein |
| TWI596107B (zh) * | 2013-06-25 | 2017-08-21 | 卡地拉保健有限公司 | 單株抗體之新穎純化方法 |
| EP2907565A1 (de) * | 2014-02-17 | 2015-08-19 | Bayer Technology Services GmbH | Dialyse-Einheit zum kontinuierlichen Puffer- bzw. Medienaustausch aus einer Proteinlösung |
| JP6783767B2 (ja) * | 2014-12-22 | 2020-11-11 | アレクシオン ファーマシューティカルズ インコーポレイテッドＡｌｅｘｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 組換えタンパク質を精製する方法 |
| EP3015542A1 (de) * | 2015-05-07 | 2016-05-04 | Bayer Technology Services GmbH | Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes |
-
2017
- 2017-07-19 EP EP17182039.2A patent/EP3431168A1/en not_active Withdrawn
-
2018
- 2018-07-12 RU RU2020107296A patent/RU2020107296A/ru unknown
- 2018-07-12 CA CA3070113A patent/CA3070113A1/en not_active Abandoned
- 2018-07-12 BR BR112020001058-8A patent/BR112020001058A2/pt not_active Application Discontinuation
- 2018-07-12 KR KR1020207004375A patent/KR20200031134A/ko not_active Application Discontinuation
- 2018-07-12 AU AU2018304504A patent/AU2018304504A1/en not_active Abandoned
- 2018-07-12 CN CN201880059650.XA patent/CN111093810A/zh active Pending
- 2018-07-12 EP EP18743719.9A patent/EP3655137A1/en not_active Withdrawn
- 2018-07-12 SG SG11202000264TA patent/SG11202000264TA/en unknown
- 2018-07-12 WO PCT/EP2018/068970 patent/WO2019016070A1/en unknown
- 2018-07-12 US US16/631,326 patent/US20200206688A1/en not_active Abandoned
- 2018-07-12 JP JP2020502328A patent/JP2020527102A/ja active Pending
- 2018-07-17 TW TW107124586A patent/TW201919747A/zh unknown
- 2018-07-19 AR ARP180102022 patent/AR112612A1/es unknown
-
2020
- 2020-01-09 IL IL271949A patent/IL271949A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3070113A1 (en) | 2019-01-24 |
| EP3431168A1 (en) | 2019-01-23 |
| BR112020001058A2 (pt) | 2020-07-14 |
| WO2019016070A1 (en) | 2019-01-24 |
| JP2020527102A (ja) | 2020-09-03 |
| EP3655137A1 (en) | 2020-05-27 |
| TW201919747A (zh) | 2019-06-01 |
| CN111093810A (zh) | 2020-05-01 |
| RU2020107296A (ru) | 2021-08-19 |
| SG11202000264TA (en) | 2020-02-27 |
| US20200206688A1 (en) | 2020-07-02 |
| AU2018304504A1 (en) | 2020-01-30 |
| KR20200031134A (ko) | 2020-03-23 |
| IL271949A (en) | 2020-02-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR112612A1 (es) | Purificación de conjugados de fármacos-anticuerpos luego del acoplamiento | |
| ES2693769T3 (es) | Línea de fluido calefactable | |
| EA201891133A8 (ru) | Водяная трубка | |
| BR112017024880A2 (pt) | conector de bolsa carregado à mola | |
| ES2723792T3 (es) | Sistema dilatador de vaina | |
| CL2009000099A1 (es) | Sistema de dialisis que comprende una fuente de fluido de dialisis, al menos una bomba para dializado hacia o desde un paciente, un recipiente para recibir fluido de efluente desde el paciente a traves de un tubo de drenaje que incluye un cuerpo al menos parcialmente rigido, con una manilla y una boca, y una celda de carga; metodo de tratamiento de dialisis. | |
| ES2038730T3 (es) | Aparato de hemodialisis con sistema de proteccion contra composicion falsa del liquido de dialisis. | |
| BR112015001876A2 (pt) | dispositivo de preenchimento de espaço | |
| BRPI0921699A8 (pt) | Complexo antioxidante, composições cosmética e farmacêutica contendo o referido complexo e uso deste complexo | |
| BR112014012145A8 (pt) | filtro de sangue, sistema e uso de um filtro de sangue ou sistema | |
| AR079773A1 (es) | Separador de aire para circulacion sanguinea extracorporal, dispositivo funcional externo, sistema de circulacion de sangre y dispositivo de tratamiento | |
| BR112017020850A2 (pt) | elemento secundário para um sistema de filtro bem como sistema de filtro com um elemento secundário | |
| BR112016010103A8 (pt) | métodos, kits e dispositivos de suprimento de fármaco osmótico. | |
| CL2019003075A1 (es) | Dispositivo único de identificación implantable y sistema de detección. | |
| BR112012018115A2 (pt) | dispositivo, sistema, e, método | |
| CO2017012860A2 (es) | Procedimiento para la fabricación de un tampón | |
| DOP2019000004A (es) | Dispositivo aplicador para copa menstrual | |
| AR092581A1 (es) | Dispositivo y metodos de administracion de multiples farmacos, de un solo canal | |
| ES2723357T3 (es) | Instalación de OI para soluciones de enjuague | |
| PE20130321A1 (es) | Un anclaje para roca tubular que contiene adhesivo | |
| BR112013000591A2 (pt) | sistema de separação multifásico | |
| AR116918A1 (es) | Uso de recambio plasmático de bajo volumen para el tratamiento de la enfermedad de alzheimer en etapas temprana y moderada | |
| ECSP109871A (es) | Soluciones farmacéuticas orales que contienen telbivudina | |
| BR112016015022A2 (pt) | Elemento de filtro que tem capacidade de dupla filtração e conjunto de filtro | |
| PH12021551094A1 (en) | Liposomial eye drops solution and uses thereof for the treatment of dry eye syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |