SG11202000264TA - Removal of unbound drug after antibody drug conjugate coupling - Google Patents

Abstract

WIPOI PCT () International Patent Classification: BOlD 61/14 (2006.01) BOlD 63/02 (2006.01) BOlD 61/24 (2006.01) A61K 47/68 (2017.01) BOlD 61/28 (2006.01) (21) International Application Number: PCT/EP2018/068970 Feed 10mt (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo run inio (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/016070 Al (43) International Publication Date 24 January 2019 (24.01.2019) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: — with international search report (Art 21(3)) (22) International Filing Date: 12 July 2018 (12.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 17182039.2 19 July 2017 (19.07.2017) EP (71) Applicant: BAYER AKTIENGESELLSCHAFT [DE/DE]; Kaiser-Wilhelm-Allee 1, 51373 Leverkusen (DE). (72) Inventor: SCHWAN, Peter; Carl-Rumpff-Str. 75, 51373 Leverkusen (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, W O 20 19/0 1607 0 Al (54) Title: REMOVAL OF UNBOUND DRUG AFTER ANTIBODY DRUG CONJUGATE COUPLING (57) : Disclosed herein is a unit for ultrafiltration and purification (1) of a product stream (3) containing a biological macromolecular product as well 1 as a substance to be separated from the product stream, comprising at least one capillary ultrafiltration module (2), characterized in that - at least one pump (4) conveys the product stream into the capillaries of the at least one capillary ul- 7 trafiltration module, - at least one positive displacement pump (5) conveys the 9 product stream from the capillaries and - at least one further pump (6) passes 13 a washing fluid (9) over the outside of the capillaries, - the unit includes no 5 — measure for circulating the product stream and the washing fluid into the ultra- filtration module, as well as at least one guard filter(8), through which all fluid leaving the at least one capillary ultrafiltration module in the direction of the product stream is passed. Fig. 1