AR109248A1 - Procedimiento para la preparación de 4-fenilbutirato y sus usos - Google Patents
Procedimiento para la preparación de 4-fenilbutirato y sus usosInfo
- Publication number
- AR109248A1 AR109248A1 ARP170101424A ARP170101424A AR109248A1 AR 109248 A1 AR109248 A1 AR 109248A1 AR P170101424 A ARP170101424 A AR P170101424A AR P170101424 A ARP170101424 A AR P170101424A AR 109248 A1 AR109248 A1 AR 109248A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- butyric acid
- procedure
- preparation
- triphenylbutyrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
- C07C69/616—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
Abstract
Un procedimiento para preparar ácido 4-fenil-1-butírico, que comprende: hacer reaccionar 4-fenil-1-butanol con clorito sódico, un catalizador del radical nitroxilo e hipoclorito sódico en un disolvente orgánico y un amortiguador de fosfato; y paralizar la reacción con sulfito sódico para producir 4-fenil-1-butírico. También ácido 4-fenil-1-butírico preparado mediante tal procedimiento. Preparación de trifenilbutirato de glicerilo y su uso en el tratamiento de un trastorno del ciclo de la urea. Reivindicación 25: Un procedimiento para preparar trifenilbutirato de glicerol, caracterizado porque comprende: convertir ácido 4-fenil-1-butírico de la reivindicación 21, en cloruro de 4-fenil-1-butirilo; y hacer reaccionar el cloruro de 4-fenil-1-butirilo con glicerol en un disolvente orgánico en presencia de una base adecuada.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/164,126 US9914692B2 (en) | 2016-05-25 | 2016-05-25 | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AR109248A1 true AR109248A1 (es) | 2018-11-14 |
Family
ID=60412929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP170101424A AR109248A1 (es) | 2016-05-25 | 2017-05-24 | Procedimiento para la preparación de 4-fenilbutirato y sus usos |
Country Status (4)
Country | Link |
---|---|
US (3) | US9914692B2 (es) |
AR (1) | AR109248A1 (es) |
TW (1) | TW201741278A (es) |
WO (1) | WO2017205515A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3263102A1 (en) | 2011-09-30 | 2018-01-03 | Horizon Therapeutics, LLC | Methods of therapeutic monitoring of nitrogen scavenging drugs |
US9914692B2 (en) | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
CN108530290A (zh) * | 2018-06-04 | 2018-09-14 | 福州华博立乐新材料科技有限公司 | 一种4-苯基-1-丁酸的合成方法 |
CN113845420B (zh) * | 2021-10-22 | 2024-04-16 | 安徽沃泰生物医药有限公司 | 苯丁酸甘油酯的合成工艺 |
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US3686238A (en) | 1970-01-19 | 1972-08-22 | Syntex Corp | Glycerol esterified with 2-naphthyl-acetic acids and fatty acids |
US4284647A (en) | 1980-03-31 | 1981-08-18 | The Johns Hopkins University | Process for waste nitrogen removal |
US4457942A (en) | 1982-08-20 | 1984-07-03 | Brusilow Saul W | Process for waste nitrogen removal |
US5635532A (en) | 1991-10-21 | 1997-06-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia |
US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
ES2157422T3 (es) | 1995-02-07 | 2001-08-16 | Brusilow Entpr Llc | Trigliceridos y esteres etilicos de acido fenilalcanoico y acido fenilalquenoico utiles en el tratamiento de diversos trastornos. |
US6219567B1 (en) | 1999-06-21 | 2001-04-17 | Cardiox Corporation | Monitoring of total ammoniacal concentration in blood |
IT1317073B1 (it) | 2000-12-12 | 2003-05-26 | Mini Ricerca Scient Tecnolog | Esteri dell'acido fenilbutirrico, procedimenti per la loro produzionee loro impiego terapeutico. |
US6372938B1 (en) * | 2001-05-21 | 2002-04-16 | Stanislaw R. Burzynski | Synthesis of 4-phenylbutyric acid |
US20030195255A1 (en) | 2002-04-12 | 2003-10-16 | Summar Marshall L. | Method for treating hepatic encephalopathies |
US20040229948A1 (en) | 2002-04-12 | 2004-11-18 | Summar Marshall L. | Method for preventing hepatic encephalopathic episodes |
US6825384B1 (en) | 2004-01-29 | 2004-11-30 | The Nutrasweet Company | Bromine free TEMPO based catalyst system for oxidation of primary and secondary alcohols using NaOCl as an oxidant |
US20050273359A1 (en) | 2004-06-03 | 2005-12-08 | Young David E | System and method of evaluating preoperative medical care and determining recommended tests based on patient health history and medical condition and nature of surgical procedure |
CN1778963A (zh) | 2004-11-23 | 2006-05-31 | 苏州艾杰生物科技有限公司 | 血氨含量测定方法及血氨诊断试剂盒 |
KR101380446B1 (ko) | 2004-11-26 | 2014-04-01 | 유씨엘 비즈니스 피엘씨 | 오르니틴 및 페닐아세테이트 또는 페닐부티레이트를 포함한간성 뇌병증 치료용 조성물 |
US20060135612A1 (en) | 2004-12-17 | 2006-06-22 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent |
US20070004805A1 (en) | 2005-07-01 | 2007-01-04 | Navinta Llc | Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate |
US20100016207A1 (en) | 2005-11-10 | 2010-01-21 | Wurtman Richard J | Methods and Compositions for Raising Levels and Release of Gamma Aminobutyric Acid |
CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
US8094521B2 (en) | 2007-02-28 | 2012-01-10 | Nightingale Products LLC | Caregiver personal alert device |
CA2711807A1 (en) | 2008-01-08 | 2009-07-16 | Akthelia Pharmaceuticals | Agonists for antimicrobial peptide systems |
PL3133396T3 (pl) | 2008-04-29 | 2019-03-29 | Horizon Therapeutics, Llc | Sposób leczenia z zastosowaniem leków wychwytujących amoniak |
WO2009145323A1 (ja) * | 2008-05-30 | 2009-12-03 | 日産化学工業株式会社 | 多環式化合物を用いるアルコールの酸化方法 |
WO2010025303A1 (en) | 2008-08-29 | 2010-03-04 | Hyperion Therapeutics | Dosing and monitoring patients on nitrogen-scavenging drugs |
LT3133396T (lt) | 2008-08-29 | 2018-11-26 | Horizon Therapeutics, Llc | Gydymo būdai, panaudojant amoniaką deaktyvuojančius vaistus |
PT2456304E (pt) | 2009-07-24 | 2015-10-12 | Baylor College Medicine | Métodos de modulação de ácidos de cadeia ramificada e utilização dos mesmos |
US8871981B2 (en) | 2010-07-16 | 2014-10-28 | Tohoku University | Method for oxidizing alcohols |
JP6049619B2 (ja) | 2010-08-31 | 2016-12-21 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | ナノヒドロキシアパタイトを含む多孔質多糖足場、及び骨形成のための使用 |
EP3263102A1 (en) | 2011-09-30 | 2018-01-03 | Horizon Therapeutics, LLC | Methods of therapeutic monitoring of nitrogen scavenging drugs |
EP2607366A1 (en) | 2011-12-21 | 2013-06-26 | Lunamed AG | Glycerol phenyl butyrate esters |
ES2807951T3 (es) | 2012-04-20 | 2021-02-24 | Immedica Pharma Ab | Métodos de monitorización terapéutica de profármacos de ácido fenilacético |
CN104797272A (zh) | 2012-11-21 | 2015-07-22 | 海波龙治疗公司 | 施用及评价用于治疗肝性脑病的氮清除药物的方法 |
CN103304402B (zh) | 2013-05-24 | 2015-04-22 | 苏州诚和医药化学有限公司 | 一种制备4-苯-1-丁酸的方法 |
WO2015048818A1 (en) | 2013-09-30 | 2015-04-02 | Hyperion Therapeutics, Inc. | Diagnosing, grading, monitoring, and treating hepatic encephalopathy |
EP2986325B1 (en) | 2013-10-14 | 2019-06-26 | Immedica Pharma AB | Methods of treating urea cycle disorders |
WO2015063659A1 (en) | 2013-10-30 | 2015-05-07 | Lupin Limited | Process for the preparation of glycerol phenylbutyrate |
WO2015187641A1 (en) | 2014-06-04 | 2015-12-10 | Horizon Therapeutics, Inc. | Methods for treating urea cycle disorders to prevent hyperammonemic crises by controlling blood ammonia levels |
WO2017147193A1 (en) | 2016-02-22 | 2017-08-31 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
US9914692B2 (en) | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
US20190076383A1 (en) | 2017-09-08 | 2019-03-14 | Horizon Therapeutics, Llc | Methods for treating urea cycle disorders |
US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
-
2016
- 2016-05-25 US US15/164,126 patent/US9914692B2/en active Active
-
2017
- 2017-05-24 AR ARP170101424A patent/AR109248A1/es unknown
- 2017-05-24 WO PCT/US2017/034286 patent/WO2017205515A1/en active Application Filing
- 2017-05-25 TW TW106117412A patent/TW201741278A/zh unknown
- 2017-09-06 US US15/696,448 patent/US10329236B2/en active Active
-
2019
- 2019-05-07 US US16/405,523 patent/US11014870B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
TW201741278A (zh) | 2017-12-01 |
WO2017205515A1 (en) | 2017-11-30 |
US20170362160A1 (en) | 2017-12-21 |
US10329236B2 (en) | 2019-06-25 |
US20170342018A1 (en) | 2017-11-30 |
US9914692B2 (en) | 2018-03-13 |
US20200002266A1 (en) | 2020-01-02 |
US11014870B2 (en) | 2021-05-25 |
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Legal Events
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