AR105324A1 - Hidrazidas de ácido carboxílico arilo y heteroarilo cíclicas sustituidas o sus sales y su uso para aumentar la tolerancia al estrés en plantas - Google Patents

Hidrazidas de ácido carboxílico arilo y heteroarilo cíclicas sustituidas o sus sales y su uso para aumentar la tolerancia al estrés en plantas

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AR105324A1
AR105324A1 ARP160102038A ARP160102038A AR105324A1 AR 105324 A1 AR105324 A1 AR 105324A1 AR P160102038 A ARP160102038 A AR P160102038A AR P160102038 A ARP160102038 A AR P160102038A AR 105324 A1 AR105324 A1 AR 105324A1
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AR
Argentina
Prior art keywords
alkyl
aryl
heteroaryl
cycloalkyl
heterocyclyl
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ARP160102038A
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English (en)
Inventor
Pedro Ruiz-Santaella Moreno Juan
Heinemann Ines
Schmutzler Dirk
Jeffrey Hills Martin
Bickers Udo
Dittgen Jan
Adelt Isabelle
Lehr Stefan
Helmke Hendrik
Brnjes Marco
Bojack Guido
Franckenpohl Jens
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Bayer Cropscience Ag
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Publication of AR105324A1 publication Critical patent/AR105324A1/es

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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
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  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cultivation Of Plants (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente solicitud se refiere a hidrazidas de ácido carboxílico arilo y heteroarilo cíclicas sustituidas para aumentar la tolerancia al estrés abiótico, así como para aumentar el crecimiento de las plantas y/o para aumentar el rendimiento de la planta. Reivindicación 1: Hidrazidas de ácido carboxílico arilo y heteroarilo cíclicas sustituidas de la fórmula general (1) o sales de los mismos, donde R¹, R² y R³⁸ representan independientemente hidrógeno, halógeno, ciano, nitro, NR³⁹R⁴⁰, OR⁴¹, S(O)ₙR⁴², tiocianato, isotiocianato, C₁₋₈-alquilo, C₂₋₈-alquenilo, C₂₋₈-alquinilo, C₁₋₁₀-haloalquilo, C₂₋₈-haloalquenilo, C₂₋₈-haloalquinilo, C₃₋₁₀-cicloalquilo, C₃₋₁₀-halocicloalquilo, C₄₋₁₀-cicloalquenilo, C₄₋₁₀-halocicloalquenilo, pentafluortio, C₁₋₈-alcoxi-C₁₋₈-haloalquilo, C₁₋₈-haloalcoxi-C₁₋₈-haloalquilo, C₁₋₈-haloalcoxi-C₁₋₈-alquilo, arilo, arilo-C₁₋₈-alquilo, heteroarilo, heteroarilo-C₁₋₈-alquilo, C₃₋₈-cicloalquilo-C₁₋₈-alquilo, C₄₋₁₀-cicloalquenilo-C₁₋₈-alquilo, heterociclilo, heterociclilo-C₁₋₈-alquilo, C₁₋₈-alcoxi-C₁₋₈-alquilo, C₁₋₈-alquiltio-C₁₋₈-alquilo, C₁₋₈-haloalquiltio-C₁₋₈-alquilo, C₁₋₈-alquilcarbonilo-C₁₋₈-alquilo, COOR⁴², CONR³⁹R⁴⁰, COR⁴¹, -C=NOR⁴¹, R⁴¹OOC-C₁₋₈-alquilo, arilo-C₁₋₈-alquinilo, heteroarilo-C₁₋₈-alquinilo, heterociclilo-C₁₋₈-alquinilo, tris-[C₁₋₈-alquilo]sililo-C₂₋₈-alquinilo, bis-[C₁₋₈-alquilo](arilo)sililo-C₂₋₈-alquinilo, bis-arilo[C₁₋₈-alquilo]sililo-C₂₋₈-alquinilo, C₃₋₈-cicloalquilo-C₂₋₈-alquinilo, arilo-C₂₋₈-alquenilo, heteroarilo-C₂₋₈-alquenilo, heterociclilo-C₂₋₈-alquenilo, C₃₋₈-cicloalquilo-C₂₋₈-alquenilo, C₁₋₈-alcoxi-C₁₋₈-alcoxi-C₁₋₈-alquilo, C₁₋₈-alquilamino sulfonilamino, C₃₋₈-cicloalquilamino sulfonilamino, diazo, diazo arilo, tris-[C₁₋₈-alquilo]sililo, bis-[C₁₋₈-alquilo](arilo)sililo, bis-arilo[C₁₋₈-alquilo]sililo; X¹, X², X³ y X⁴ son iguales o diferentes y representan independientemente N (nitrógeno) o la agrupación C-R², sin embargo en ningún caso más de dos átomos N son adyacentes, y en el que R² en la agrupación C-R² tiene los mismos o diferentes significados respectivamente según se define a continuación, y en el que R¹ y R² no son simultáneamente hidrógeno si X¹, X², X³ y X⁴ representan C-R²; W es O (oxígeno) o S (azufre); A¹, A², A³, A⁴ y A⁵ son iguales o diferentes y representan independientemente N (nitrógeno) o la agrupación C-R³⁸, sin embargo en ningún caso más de dos átomos N son adyacentes, y en el que R³⁸ en la agrupación C-R³⁸ tiene los mismos o diferentes significados respectivamente según la definición anterior; Q junto con el grupo CR³R⁴ y el átomo de nitrógeno al que están unidos forman un anillo de 3 - 7 miembros totalmente saturado, parcialmente saturado o totalmente insaturado, opcionalmente interrumpido por heteroátomos y además opcionalmente sustituido y además representa a los grupos Q-1 a Q-15 del grupo de fórmulas (2) en el que R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹, R²⁰, R²¹, R²², R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸, R²⁹, R³⁰, R³¹, R³², R³³, R³⁴, R³⁵, R³⁶ y R³⁷ tiene cada uno el significado según las siguientes definiciones y donde la flecha representa un enlace con el átomo-N del grupo hidrazida; R³, R⁴, R¹⁷, R¹⁸, R¹⁹ y R²⁰ representan independientemente hidrógeno, C₁₋₈-alquilo, halógeno, NR³⁹R⁴⁰, S(O)ₙR⁴², ciano, nitro, ciano-C₁₋₈-alquilo, C₃₋₁₀-cicloalquilo, C₃₋₁₀-halocicloalquilo, C₄₋₁₀-cicloalquenilo, C₄₋₁₀-halocicloalquenilo, C₁₋₁₀-haloalquilo, arilo, arilo-C₁₋₈-alquilo, heteroarilo, heteroarilo-C₁₋₈-alquilo, C₃₋₈-cicloalquilo-C₁₋₈-alquilo, C₂₋₈-haloalquinilo, C₂₋₈-alquinilo, C₂₋₈-alquenilo, C₂₋₈-haloalquenilo, heterociclilo, heterociclilo-C₁₋₈-alquilo, C₁₋₈-alquiltio-C₁₋₈-alquilo, C₁₋₈-haloalcoxi-C₁₋₈-alquilo, C₁₋₈-haloalquiltio-C₁₋₈-alquilo, C₁₋₈-alquilamino-C₁₋₈-alquilo, bis-[C₁₋₈-alquilo]amino-C₁₋₈-alquilo, C₃₋₈-cicloalquilamino-C₁₋₈-alquilo, C₁₋₈-alcoxi-C₁₋₈-alcoxi-C₁₋₈-alquilo, COR⁴¹, COOR⁴¹, CONR³⁹R⁴⁰, hidroxicarbonilo-C₁₋₈-alquilo, C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, C₂₋₈-alqueniloxicarbonilo-C₁₋₈-alquilo, C₂₋₈-alquiniloxicarbonilo-C₁₋₈-alquilo, arilo-C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, C₁₋₈-alquilcarbonilo-C₁₋₈-alquilo o junto al átomo al que están unidos forman un grupo oxo; R⁵ y R⁶ representan independientemente hidrógeno, C₁₋₈-alquilo, C₂₋₈-alquenilo, C₂₋₈-alquinilo, C₁₋₁₀-haloalquilo, C₂₋₈-haloalquenilo, C₂₋₈-haloalquinilo, C₃₋₁₀-cicloalquilo, C₃₋₁₀-halocicloalquilo, C₄₋₁₀-cicloalquenilo, C₄₋₁₀-halocicloalquenilo, arilo, arilo-C₁₋₈-alquilo, heteroarilo, heteroarilo-C₁₋₈-alquilo, C₃₋₈-cicloalquilo-C₁₋₈-alquilo, heterociclilo, heterociclilo-C₁₋₈-alquilo, C₁₋₈-alcoxi-C₁₋₈-alquilo, C₁₋₈-alquiltio-C₁₋₈-alquilo, C₁₋₈-haloalcoxi-C₁₋₈-alquilo, C₁₋₈-haloalquiltio-C₁₋₈-alquilo, COOR⁴¹, CONR³⁹R⁴⁰, hidroxicarbonilo-C₁₋₈-alquilo, C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, C₂₋₈-alqueniloxicarbonilo-C₁₋₈-alquilo, C₂₋₈-alquiniloxicarbonilo-C₁₋₈-alquilo, arilo-C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, heteroarilo-C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, heterociclilo-C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo; R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R²¹, R²², R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸, R²⁹, R³⁰, R³¹, R³², R³³, R³⁴, R³⁵ y R³⁶ representan independientemente hidrógeno, ciano, nitro, halógeno, hidroxi, C₁₋₈-alquilo, C₁₋₈-alcoxi, C₁₋₈-alquiltio, C₁₋₈-haloalcoxi, C₁₋₈-haloalquiltio, C₃₋₁₀-cicloalquilo, C₁₋₁₀-haloalquilo, arilo, arilo-C₁₋₈-alquilo, heteroarilo, heteroarilo-C₁₋₈-alquilo, C₃₋₈-cicloalquilo-C₁₋₈-alquilo, C₂₋₈-haloalquinilo, C₂₋₈-alquinilo, C₂₋₈-alquenilo, C₂₋₈-haloalquenilo, heterociclilo, heterociclilo-C₁₋₈-alquilo, C₁₋₈-alquiltio-C₁₋₈-alquilo, C₁₋₈-haloalcoxi-C₁₋₈-alquilo, C₁₋₈-haloalquiltio-C₁₋₈-alquilo, COR⁴¹, COOR⁴¹, CONR³⁹R⁴⁰; R³⁷ representa hidrógeno, C₁₋₈-alquilo, C₂₋₈-alquenilo, C₂₋₈-alquinilo C₃₋₁₀-cicloalquilo, C₄₋₁₀-cicloalquenilo, C₁₋₁₀-haloalquilo, C₁₋₈-alcoxi, C₂₋₈-alqueniloxi, arilo, heteroarilo, heterociclilo, COR⁴¹, COOR⁴¹, CONR³⁹R⁴⁰, S(O)ₙR⁴²; n es 0, 1 ó 2; R³⁹ y R⁴⁰ iguales o diferentes y representan independientemente hidrógeno, C₁₋₈-alquilo, C₂₋₈-alquenilo, C₂₋₈-alquinilo, C₁₋₈-cianoalquilo, C₁₋₁₀-haloalquilo, C₂₋₈-haloalquenilo, C₂₋₈-haloalquinilo, C₃₋₁₀-cicloalquilo, C₃₋₁₀-halocicloalquilo, C₄₋₁₀-cicloalquenilo, C₄₋₁₀-halocicloalquenilo, C₁₋₈-alcoxi-C₁₋₈-alquilo, C₁₋₈-haloalcoxi-C₁₋₈-alquilo, C₁₋₈-alquiltio-C₁₋₈-alquilo, C₁₋₈-haloalquiltio-C₁₋₈-alquilo, C₁₋₈-alcoxi-C₁₋₈-haloalquilo, arilo, arilo-C₁₋₈-alquilo, heteroarilo, heteroarilo-C₁₋₈-alquilo, C₃₋₈-cicloalquilo-C₁₋₈-alquilo, C₄₋₁₀-cicloalquenilo-C₁₋₈-alquilo, COR⁴¹, SO₂R⁴², C₁₋₈-alquilo-HNO₂S-, C₃₋₈-cicloalquilo-HNO₂S-, heterociclilo, C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, C₁₋₈-alcoxicarbonilo, arilo-C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, arilo-C₁₋₈-alcoxicarbonilo, heteroarilo-C₁₋₈-alcoxicarbonilo, C₂₋₈-alqueniloxicarbonilo, C₂₋₈-alquiniloxicarbonilo, heterociclilo-C₁₋₈-alquilo; R⁴¹ representa hidrógeno, C₁₋₈-alquilo, C₂₋₈-alquenilo, C₂₋₈-alquinilo, C₁₋₈-cianoalquilo, C₁₋₁₀-haloalquilo, C₂₋₈-haloalquenilo, C₂₋₈-haloalquinilo, C₃₋₁₀-cicloalquilo, C₃₋₁₀-halocicloalquilo, C₄₋₁₀-cicloalquenilo, C₄₋₁₀-halocicloalquenilo, C₁₋₈-alcoxi-C₁₋₈-alquilo, C₁₋₈-alcoxi-C₁₋₈-haloalquilo, arilo, arilo-C₁₋₈-alquilo, heteroarilo, heteroarilo-C₁₋₈-alquilo, C₃₋₈-cicloalquilo-C₁₋₈-alquilo, C₄₋₁₀-cicloalquenilo-C₁₋₈-alquilo, C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, C₂₋₈-alqueniloxicarbonilo-C₁₋₈-alquilo, arilo-C₁₋₈-alcoxicarbonilo-C₁₋₈-alquilo, hidroxicarbonilo-C₁₋₈-alquilo, heterociclilo, heterociclilo-C₁₋₈-alquilo; y R⁴² representa hidrógeno, C₁₋₈-alquilo, C₂₋₈-alquenilo, C₂₋₈-alquinilo, C₁₋₈-cianoalquilo, C₁₋₁₀-haloalquilo, C₂₋₈-haloalquenilo, C₂₋₈-haloalquinilo, C₃₋₁₀-cicloalquilo, C₃₋₁₀-halocicloalquilo, C₄₋₁₀-cicloalquenilo, C₄₋₁₀-halocicloalquenilo, C₁₋₈-alcoxi-C₁₋₈-alquilo, C₁₋₈-alcoxi-C₁₋₈-haloalquilo, arilo, arilo-C₁₋₈-alquilo, heteroarilo, heteroarilo-C₁₋₈-alquilo, heterociclilo-C₁₋₈-alquilo, C₃₋₈-cicloalquilo-C₁₋₈-alquilo, C₄₋₁₀-cicloalquenilo-C₁₋₈-alquilo, NR³⁹R⁴⁰; Y es un enlace o representa los grupos Y-1 a Y-7 del grupo de fórmulas (3) en el que R⁴³, R⁴⁴, R⁴⁵, R⁴⁶, R⁴⁷, R⁴⁸, R⁴⁹, R⁵⁰, R⁵¹, R⁵², R⁵³ y R⁵⁴ tiene cada uno el significado que se define a continuación y en el que la flecha representa un enlace del anillo de 6 miembros con los grupos A¹, A², A³, A⁴ y A⁵; R⁴³, R⁴⁴, R⁴⁵, R⁴⁶, R⁴⁷, R⁴⁸, R⁴⁹, R⁵⁰, R⁵¹, R⁵², R⁵³ y R⁵⁴ representan independientemente hidrógeno, C₁₋₈-alquilo, C₂₋₈-alquenilo, C₂₋₈-alquinilo, C₁₋₁₀-haloalquilo, C₂₋₈-haloalquenilo, C₂₋₈-haloalquinilo, C₃₋₁₀-cicloalquilo, arilo, arilo-C₁₋₈-alquilo, heteroarilo, heteroarilo-C₁₋₈-alquilo, C₃₋₈-cicloalquilo-C₁₋₈-alquilo, heterociclilo, heterociclilo-C₁₋₈-alquilo, C₁₋₈-alcoxi-C₁₋₈-alquilo, C₁₋₈-alquiltio-C₁₋₈-alquilo, C₁₋₈-haloalcoxi-C₁₋₈-alquilo, C₁₋₈-haloalquiltio-C₁₋₈-alquilo, COOR²³; R¹ y X¹, si X¹ representa un grupo C-R², forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado, parcialmente saturado o totalmente insaturado, opcionalmente interrumpido por heteroátomos, con los átomos a los que están unidos; X¹ y X², si ambos representan un grupo C-R², forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado, parcialmente saturado o totalmente insaturado, opcionalmente interrumpido por heteroátomos, con los átomos a los que están unidos; A¹ y A², si ambos representan un grupo C-R⁷, forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado, parcialmente saturado o totalmente instaurado, opcionalmente interrumpido por heteroátomos, con los átomos a los que están unidos; A² y A³, si ambos representan un grupo C-R⁷, forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado, parcialmente saturado o totalmente instaurado, opcionalmente interrumpido por heteroátomos, con los átomos a los que están unidos; A³ y A⁴, si ambos representan un grupo C-R⁷, forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado, parcialmente saturado o totalmente insaturado, opcionalmente interrumpido por heteroátomos, con los átomos a los que están unidos; R³ y R⁴ con el átomo al que están unidos, forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado o parcialmente saturado, opcionalmente interrumpido por heteroátomos, opcionalmente sustituidos; R⁵ y R⁶ con el átomo al que están unidos, forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado o parcialmente saturado, opcionalmente interrumpido por heteroátomos, opcionalmente sustituidos; R³ y R²³ con el átomo al que están unidos, forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado o parcialmente saturado, opcionalmente interrumpido por heteroátomos, opcionalmente sustituidos; R⁹ y R¹⁰ con el átomo al que están unidos, forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado o parcialmente saturado, opcionalmente interrumpido por heteroátomos, opcionalmente sustituidos; y R¹⁵ y R¹⁶ con el átomo al que están unidos, forman un anillo de 5 - 7 miembros opcionalmente sustituido, totalmente saturado o parcialmente saturado, opcionalmente interrumpido por heteroátomos, opcionalmente sustituidos.
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