AR102852A1 - Inhibidores heterocíclicos de la calicreína plasmática - Google Patents

Inhibidores heterocíclicos de la calicreína plasmática

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Publication number
AR102852A1
AR102852A1 ARP150103902A ARP150103902A AR102852A1 AR 102852 A1 AR102852 A1 AR 102852A1 AR P150103902 A ARP150103902 A AR P150103902A AR P150103902 A ARP150103902 A AR P150103902A AR 102852 A1 AR102852 A1 AR 102852A1
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Argentina
Prior art keywords
methyl
carboxamide
amino
pyrazol
phenyl
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ARP150103902A
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English (en)
Inventor
Hodgson Simon
Louise Marsh Sally
Louise Davie Rebecca
John Stocks Michael
Joy Edwards Hannah
Michael Evans David
Richard Novak Andrew
John Smith Alun
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Kalvista Pharmaceuticals Ltd
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Publication of AR102852A1 publication Critical patent/AR102852A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

El uso de éstos compuestos en terapia (por ejemplo en el tratamiento o prevención de una enfermedad o condición en donde está implicada la actividad de la calicreína plasmática). Reivindicación 1: Un compuesto caracterizado porque se selecciona entre: diclorhidrato de N-((1-aminoisoquinolin-6-il)metil)-3-(metoximetil)-1-((6-(pirrolidin-1-il)piridin-3-il)metil)-1H-pirazol-4-carboxamida; N-((1-aminoisoquinolin-6-il)metil)-3-(metoximetil)-1-((5-((4-metil-1H-pirazol-1-il)metil)piridin-2-il)metil)-1H-pirazol-4-carboxamida; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 3-ciano-1-[6-(3,3-difluoro-pirrolidin-1-il)-5-metoxi-piridin-3-ilmetil]-1H-pirazol-4-carboxílico; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 3-metoximetil-1-(4-pirazol-1-ilmetil-bencil)-1H-pirazol-4-carboxílico; N-[(1-amino-5-metilisoquinolin-6-il)metil]-3-(metoximetil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-3-(metoximetil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 3-metoximetil-1-(2-pirrolidin-1-il-pirimidin-5-ilmetil)-1H-pirazol-4-carboxílico; N-[(1-amino-5-metilisoquinolin-6-il)metil]-3-(metoximetil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-3-(metoximetil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-3-(metoximetil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-3-(metoximetil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 1-[2-(3,3-difluoro-pirrolidin-1-il)-pirimidin-5-ilmetil]-3-metoximetil-1H-pirazol-4-carboxílico; N-[(1-amino-5-metilisoquinolin-6-il)metil]-1-{[2-(3,3-difluoropirrolidin-1-il)pirimidin-5-il]metil}-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-1-{[2-(3,3-difluoropirrolidin-1-il)pirimidin-5-il]metil}-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-3-(metoximetil)pirazol-4-carboxamida; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 3-(2-metoxi-etil)-1-(6-pirrolidin-1-il-piridin-3-ilmetil)-1H-pirazol-4-carboxílico; N-[(1-amino-5-metilisoquinolin-6-il)metil]-3-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}pirazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-3-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}pirazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}pirazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}pirazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-3-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}pirazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-3-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}pirazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}pirazol-4-carboxamida; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 3-etoximetil-1-(4-pirazol-1-ilmetil-bencil)-1H-pirazol-4-carboxílico; N-[(1-aminoisoquinolin-6-il)metil]-1-{[2-(pirazol-1-ilmetil)pirimidin-5-il]metil}-3-(trifluorometil)pirazol-4-carboxamida; N-[(1-aminoisoquinolin-6-il)metil]-1-({3-fluoro-4-[(4-metilpirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-[(1-aminoisoquinolin-6-il)metil]-1-({2-fluoro-4-[(4-metilpirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 3-ciclopropil-1-(2-fluoro-4-pirazol-1-ilmetil-bencil)-1H-pirazol-4-carboxílico; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 3-ciclopropil-1-[4-(4-fluoro-pirazol-1-ilmetil)-bencil]-1H-pirazol-4-carboxílico; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 1-[4-(4-fluoro-pirazol-1-ilmetil)-bencil]-3-metoximetil-1H-pirazol-4-carboxílico; N-[(1-amino-5-metilisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-[(1-aminoisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(trifluorometil)pirazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-3-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-3-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-3-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-3-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-3-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; (3-cloro-1H-pirrolo[2,3-b]piridin-5-ilmetil)-amida de ácido 1-(6-pirrolidin-1-il-piridin-3-ilmetil)-3-trifluorometil-1H-pirazol-4-carboxílico; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-1-{[2-(pirrolidin-1-il)piridin-4-il]metil}-3-(trifluorometil)pirazol-4-carboxamida; 3-amino-N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-1-{[2-(pirrolidin-1-il)piridin-4-il]metil}pirazol-4-carboxamida; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-3-ciano-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; 3-amino-N-({3-cloro-1H-pirrolo[2,3-b]piridin-5-il}metil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; (3-cloro-1H-pirrolo[2,3-b]piridin-5-ilmetil)-amida de ácido 1-(2-pirrolidin-1-il-pirimidin-5-ilmetil)-3-trifluorometil-1H-pirazol-4-carboxílico; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-3-(metoximetil)-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}pirazol-4-carboxamida; N-({3-cloro-1H-pirrolo[2,3-b]piridin-5-il}metil)-1-{[6-(3,3-difluoropirrolidin-1-il)piridin-3-il]metil}-3-(trifluorometil)pirazol-4-carboxamida; 3-amino-N-({3-cloro-1H-pirrolo[2,3-b]piridin-5-il}metil)-1-{[6-(3,3-difluoropirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-1-{[6-(3,3-difluoropirrolidin-1-il)piridin-3-il]metil}-3-(metoximetil)pirazol-4-carboxamida; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-1-[(6-etoxi-5-fluoropiridin-3-il)metil]-3-(trifluorometil)pirazol-4-carboxamida; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-1-({6-[isopropil(metil)amino]piridin-3-il}metil)-3-(trifluorometil)pirazol-4-carboxamida; 3-amino-1-{[6-(benciloxi)piridin-3-il]metil}-N-({3-cloro-1H-pirrolo[2,3-b]piridin-5-il}metil)-1H-pirazol-4-carboxamida; 3-amino-N-({3-cloro-1H-pirrolo[2,3-b]piridin-5-il}metil)-1-{[6-(fenoximetil)piridin-3-il]metil}-1H-pirazol-4-carboxamida; 3-amino-N-({3-cloro-1H-pirrolo[2,3-b]piridin-5-il}metil)-1-[(6-fenoxipiridin-3-il)metil]-1H-pirazol-4-carboxamida; (3-cloro-1H-pirrolo[2,3-b]piridin-5-ilmetil)-amida de ácido 3-metoximetil-1-[4-(4-metil-pirazol-1-ilmetil)-bencil]-1H-pirazol-4-carboxílico; (3-cloro-1H-pirrolo[2,3-b]piridin-5-ilmetil)-amida de ácido 3-ciano-1-[4-(4metil-pirazol-1-ilmetil)-bencil]-1H-pirazol-4-carboxílico; 3-amino-N-({3-cloro-1H-pirrolo[2,3-b]piridin-5-il}metil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-3-(metoximetil)pirazol-4-carboxamida; N-({3-cloro-1H-pirrolo[2,3-b]piridin-5-il}metil)-3-(metoximetil)-1-[(2-metilquinolin-6-il)metil]pirazol-4-carboxamida; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-1-[(7-cloroquinolin-3-il)metil]-3-(metoximetil)pirazol-4-carboxamida; 3-amino-N-[(3-cloro-1H-indol-5-il)metil]-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)pirazol-4-carboxamida; 3-amino-N-[(3-cloro-1H-indazol-5-il)metil]-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-({3-ciano-1H-pirrolo[2,3-b]piridin-5-il}metil)-3-ciclopropil-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-({3-fluoro-1H-pirrolo[2,3-b]piridin-5-il}metil)-3-(metoximetil)-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-({4-metil-1H-pirrolo[2,3-b]piridin-5-il}metil)-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)-3-(trifluorometil)pirazol-4-carboxamida; N-({1-metilpirazolo[3,4-b]piridin-5-il}metil)-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)-3-(trifluorometil)pirazol-4-carboxamida; N-({3-cloro-1H-pirrolo[2,3-c]piridin-5-il}metil)-3-(metoximetil)-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)pirazol-4-carboxamida; 3-amino-N-[(6-cloroisoquinolin-3-il)metil]-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-[(6-cloroisoquinolin-3-il)metil]-3-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)pirazol-4-carboxamida; N-[(6-cloroisoquinolin-3-il)metil]-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}-3-(trifluorometil)pirazol-4-carboxamida; N-[(6-cloroisoquinolin-3-il)metil]-3-(metoximetil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-2-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-2-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-2-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-ciclopropil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-ciclopropil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-{[4-(pirazol-1-ilmetil)fenil]metil}imidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-2-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-2-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-2-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-2-metilimidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-2-metilimidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-2-metilimidazol-4-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-2-metilimidazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-2-metilimidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-2-metilimidazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-2-metilimidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-5-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-7-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-amino-8-metoxilsoquinolin-6-il)metil]-2-ciclopropil-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; (1-amino-isoquinolin-6-ilmetil)-amida de ácido 2-metil-1-(6-pirrolidin-1-il-piridin-3-ilmetil)-1H-imidazol-4-carboxílico; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-metil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-metil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-metil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-2-metil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-2-metil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-metil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-2-metil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-ciclopropil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-ciclopropil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(6-cloroisoquinolin-3-il)metil]-2-metil-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-({3-cloro-1 H-pirrolo[2,3-b]piridin-5-il}metil)-2-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-({5-cloro-7H-pirrolo[2,3-b]piridin-3-il}metil)-2-metil-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)imidazol-4-carboxamida; N-[(1-aminoisoquinolin-6-il)metil]-2-metil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-metil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-metil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-metil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-2-metil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-2-metil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-metil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-2-metil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(pirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-1-{[2-(3,3-difluoropirrolidin-1-il)pirimidin-5-il]metil}-2-metilimidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-1-{[2-(3,3-difluoropirrolidin-1-il)pirimidin-5-il]metil}-2-metilimidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-2-metilimidazol-4-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-2-metilimidazol-4-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-2-metilimidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-2-metilimidazol-4-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}-2-metilimidazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(3,3-difluoropirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(3,3-difluoropirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(3,3-difluopropirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-2-ciclopropil-1-{[6-(3,3-difluopropirrolidin-1-il)piridin-3-il]metil}imidazol-4-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-2-ciclopropil-1-{[2-(3,3-difluoropirrolidin-1-il)pirimidin-5-il]metil}imidazol-4-carboxamida; 3-amino-N-[(3-cloro-1H-indazol-5-il)metil]-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-({3-cloro-1H-pirazolo[3,4-b]piridin-5-il}metil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}-3-(trifluorometil)pirazol-4-carboxamida; N-({5-cloro-1H-pirrolo[2,3-b]piridin-3-il}metil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}-3-(trifluorometil)pirazol-4-carboxamida; N-({3-cloro-1H-pirrolo[2,3-c]piridin-5-il}metil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}-3-(trifluorometil)pirazol-4-carboxamida; 3-amino-N-[(7-cloroquinolin-2-il)metil]-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-3-(metoximetil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-3-(metoximetil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-3-(metoximetil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-3-(metoximetil)-1-{[6-(pirrolidin-1-il)piridin-3-il]metil}pirazol-4-carboxamida; N-[(1-aminoisoquinolin-6-il)metil]-5-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-aminoisoquinolin-6-il)metil]-5-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-5-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-5-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-5-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-5-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-5-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-5-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-5-metil-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-5-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-5-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-5-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-5-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-5-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-5-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-5-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-5-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-5-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-5-metil-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-5-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-5-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-5-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-metil-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-metil-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-metil-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-metil-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-metil-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-metil-1,2,4-triazol-3-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-metil-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metoxiisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-(metoximetil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-fluoroisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-(metoximetil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-8-metoxiisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-(metoximetil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-5-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-5-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-5-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-5-(metoximetil)-1-{[4-(pirazol-1-ilmetil)fenil]metil}-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-5-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-5-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-5-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-5-(metoximetil)-1-({4-[(4-metilpirazol-1-il)metil]fenil}metil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metilisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-(metoximetil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metilisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-(metoximetil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-fluoroisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-(metoximetil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-5-metoxiisoquinolin-6-il)metil]-1-({4-[(4-fluoropirazol-1-il)metil]fenil}metil)-5-(metoximetil)-1,2,4-triazol-3-carboxamida; N-[(1-amino-7-metilisoquino
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