AR093146A1 - Dispositivo de electroporacion - Google Patents

Dispositivo de electroporacion

Info

Publication number
AR093146A1
AR093146A1 ARP130103895A ARP130103895A AR093146A1 AR 093146 A1 AR093146 A1 AR 093146A1 AR P130103895 A ARP130103895 A AR P130103895A AR P130103895 A ARP130103895 A AR P130103895A AR 093146 A1 AR093146 A1 AR 093146A1
Authority
AR
Argentina
Prior art keywords
coverage area
electrodes
wave
electrical signals
electroporation device
Prior art date
Application number
ARP130103895A
Other languages
English (en)
Inventor
Dhillon Punit
Mcluskey Brian
Original Assignee
Oncosec Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncosec Medical Inc filed Critical Oncosec Medical Inc
Publication of AR093146A1 publication Critical patent/AR093146A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502—Skin piercing electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A61F2007/0075—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a Peltier element, e.g. near the spot to be heated or cooled

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Un dispositivo de electroporación produce señales eléctricas que se pueden ajustar como respuesta a un área de cobertura de electrodos de modo que las señales eléctricas son tolerables cuando son suministradas a las células dentro del área de cobertura, El dispositivo de electroporación puede incluir un aplicador, una pluralidad de electrodos que se extienden desde el aplicador, una fuente de energía en comunicación eléctrica con los electrodos y un miembro guiador acoplado a los electrodos. Los electrodos están asociados con un área de cobertura. La fuente de energía se configura para generar una o más señales de electroporación para las células dentro del área de cobertura. El miembro guiador se configura para ajustar el área de cobertura de los electrodos. En algunas formas de realización las señales eléctricas pueden incluir ondas opuestas que producen una onda de interferencia resultante para efectivamente elegir como blanco el área de cobertura y cada onda puede ser una onda unipolar o una onda bipolar.
ARP130103895A 2012-10-25 2013-10-25 Dispositivo de electroporacion AR093146A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718561P 2012-10-25 2012-10-25
US201361767078P 2013-02-20 2013-02-20
US201361791968P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
AR093146A1 true AR093146A1 (es) 2015-05-20

Family

ID=50545482

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130103895A AR093146A1 (es) 2012-10-25 2013-10-25 Dispositivo de electroporacion

Country Status (5)

Country Link
US (2) US9020605B2 (es)
EP (1) EP2911736A4 (es)
AR (1) AR093146A1 (es)
TW (1) TW201422276A (es)
WO (1) WO2014066655A2 (es)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US9598691B2 (en) 2008-04-29 2017-03-21 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US9700368B2 (en) 2010-10-13 2017-07-11 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
CN103555574A (zh) 2013-11-11 2014-02-05 苏州文曲生物微系统有限公司 一种流式电穿孔装置
CN112807074A (zh) 2014-05-12 2021-05-18 弗吉尼亚暨州立大学知识产权公司 电穿孔系统
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
US10694972B2 (en) 2014-12-15 2020-06-30 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
EP3277368B1 (en) * 2015-03-31 2020-05-20 OncoSec Medical Incorporated Systems for improved tissue-sensing based electroporation
US9630012B2 (en) 2015-08-06 2017-04-25 Meagan Medical, Inc. Spinal cord stimulation with interferential current
WO2017044987A2 (en) * 2015-09-10 2017-03-16 Nitesh Ratnakar Novel 360-degree panoramic view formed for endoscope adapted thereto with multiple cameras, and applications thereof to reduce polyp miss rate and facilitate targeted polyp removal
US20190009081A1 (en) * 2015-12-28 2019-01-10 Inovio Pharmaceuticals, Inc. Electroporation device with improved signal generator
KR102711822B1 (ko) * 2015-12-30 2024-09-30 이노비오 파마수티컬즈, 인크. 락-아웃 시스템으로 분리가능한 바늘 어레이를 갖는 전기천공 디바이스
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US20200147361A1 (en) * 2017-05-03 2020-05-14 Mayo Foundation For Medical Education And Research Skin treatment devices and methods
DK3645719T3 (da) 2017-06-30 2022-05-16 Inscripta Inc Automatiserede cellebehandlingsfremgangsmåder, moduler, instrumenter og systemer
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
SE541651C2 (en) * 2017-07-28 2019-11-19 Scandinavian Chemotech Ab An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal
EP3668430B1 (en) 2017-08-16 2024-02-14 Old Dominion University Research Foundation Targeted remote electrostimulation by interference of bipolar nanosecond pulses
US10738327B2 (en) 2017-08-28 2020-08-11 Inscripta, Inc. Electroporation cuvettes for automation
CN111372650A (zh) 2017-09-30 2020-07-03 因思科瑞普特公司 流通式电穿孔仪器
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
JP6840070B2 (ja) * 2017-12-18 2021-03-10 パナソニックＩｐマネジメント株式会社 薬剤浸透装置
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
CN112204131A (zh) 2018-03-29 2021-01-08 因思科瑞普特公司 用于诱导和转化的细胞生长速率的自动化控制
WO2019200004A1 (en) 2018-04-13 2019-10-17 Inscripta, Inc. Automated cell processing instruments comprising reagent cartridges
US10557216B2 (en) 2018-04-24 2020-02-11 Inscripta, Inc. Automated instrumentation for production of T-cell receptor peptide libraries
US10508273B2 (en) 2018-04-24 2019-12-17 Inscripta, Inc. Methods for identifying selective binding pairs
US10858761B2 (en) 2018-04-24 2020-12-08 Inscripta, Inc. Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
KR20210018228A (ko) 2018-05-02 2021-02-17 온코섹 메디컬 인코포레이티드 전기천공 시스템, 방법, 및 장치
EP3813974A4 (en) 2018-06-30 2022-08-03 Inscripta, Inc. INSTRUMENTS, MODULES AND METHODS FOR ENHANCED DETECTION OF EDITED SEQUENCES IN LIVING CELLS
AU2019299533B2 (en) * 2018-07-03 2023-03-09 Novocure Gmbh Using alternating electric fields to increase cell membrane permeability
US10532324B1 (en) 2018-08-14 2020-01-14 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
US10752874B2 (en) 2018-08-14 2020-08-25 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
HUE059062T2 (hu) 2018-08-23 2022-10-28 Novocure Gmbh Váltakozó elektromos mezõk alkalmazása vér-agy gát permeabilitásának növelésére
CN112955540A (zh) 2018-08-30 2021-06-11 因思科瑞普特公司 在自动化模块和仪器中对经核酸酶经编辑的序列的改进的检测
CA3118718C (en) * 2018-11-08 2023-09-26 Old Dominion University Research Foundation Megahertz compression of nanosecond pulse bursts
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
US11660139B2 (en) 2019-04-10 2023-05-30 Radioclash Inc. Electroporation probe
US10907125B2 (en) 2019-06-20 2021-02-02 Inscripta, Inc. Flow through electroporation modules and instrumentation
CA3139124C (en) 2019-06-21 2023-01-31 Inscripta, Inc. Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli
US10927385B2 (en) 2019-06-25 2021-02-23 Inscripta, Inc. Increased nucleic-acid guided cell editing in yeast
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
WO2021003451A1 (en) * 2019-07-02 2021-01-07 Kytopen Corporation Devices, systems, and kits for electro-mechanical delivery and methods of use thereof
US12098212B2 (en) 2019-08-12 2024-09-24 Purinomia Biotech, Inc. Methods and compositions for promoting and potentiating T-cell mediated immune responses through ADCC targeting of CD39 expressing cells
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
US12076556B2 (en) * 2019-12-11 2024-09-03 Novocure Gmbh Compositions and methods of altering the electric impedance to an alternating electric field
JP2023505578A (ja) * 2019-12-11 2023-02-09 ノボキュア ゲーエムベーハー 交流電場に対する電気インピーダンスを変化させる方法
US10689669B1 (en) 2020-01-11 2020-06-23 Inscripta, Inc. Automated multi-module cell processing methods, instruments, and systems
EP4096770A1 (en) 2020-01-27 2022-12-07 Inscripta, Inc. Electroporation modules and instrumentation
USD923199S1 (en) 2020-03-02 2021-06-22 Maxcyte, Inc. Electroporation device
USD923200S1 (en) 2020-03-02 2021-06-22 MaxCyte, Inc Electroporation device
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
JP2023525043A (ja) * 2020-05-08 2023-06-14 ユニバーシティー オブ メイン システム ボード オブ トラスティーズ ニューロパチーの処置のための方法およびデバイス
US11787841B2 (en) 2020-05-19 2023-10-17 Inscripta, Inc. Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
TWI815147B (zh) * 2020-07-21 2023-09-11 財團法人國家衛生研究院 基於核酸疫苗的方法
IT202000031379A1 (it) 2020-12-18 2022-06-18 Curaleaf International Ltd Formulazione farmaceutica topica e metodo per il trattamento delle sindromi associate a dolore pelvico cronico
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
TW202334196A (zh) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1結合多肽
EP4412711A1 (en) 2021-10-07 2024-08-14 Avacta Life Sciences Limited Serum half-life extended pd-l1 binding polypeptides
KR20230121575A (ko) 2022-02-10 2023-08-18 주식회사 아피셀테라퓨틱스 Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도
CN116269733B (zh) * 2023-03-20 2024-05-03 成都飞云科技有限公司 一种脉冲消融导管、装置及脉冲消融方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036858A (en) 1990-03-22 1991-08-06 Carter John L Method and apparatus for changing brain wave frequency
IE912528A1 (en) 1990-07-19 1992-01-29 Scripps Clinic Res Inhabition of mac-1 receptor binding fibrinogen using d30¹homologs
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6152882A (en) 1999-01-26 2000-11-28 Impulse Dynamics N.V. Apparatus and method for chronic measurement of monophasic action potentials
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7871427B2 (en) * 2005-02-08 2011-01-18 Carewave, Inc. Apparatus and method for using a portable thermal device to reduce accommodation of nerve receptors
AU2007260354B2 (en) * 2006-06-12 2014-01-23 Region Hovedstaden V/Herlev Hospital Electrode introducer device
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US8361066B2 (en) 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices

Also Published As

Publication number Publication date
US9020605B2 (en) 2015-04-28
EP2911736A4 (en) 2016-06-15
WO2014066655A2 (en) 2014-05-01
US20140121728A1 (en) 2014-05-01
TW201422276A (zh) 2014-06-16
US20150297887A1 (en) 2015-10-22
EP2911736A2 (en) 2015-09-02
WO2014066655A3 (en) 2014-06-12

Similar Documents

Publication Publication Date Title
AR093146A1 (es) Dispositivo de electroporacion
CL2009001634U1 (es) Un parche con un dispositivo estimulador de nervios transcutaneo electrico, comprende una banda alargada que presenta: un modulo central con un panel controlador del paso de la corriente entre dos electrodos, dos pestanas a ambos lados del modulo cada una de las cuales esta asociada a uno de los electrodos.
WO2015066670A3 (en) Nerve stimulator system
WO2013026884A3 (en) Electrosurgical device and methods of manufacture and use
WO2017042539A3 (en) Electrode apparatus
WO2016057855A8 (en) Methods and apparatus for stimulation of biological tissue
MX359036B (es) Dispositivo de electroterapia.
MY168863A (en) Biomedical patches with aligned fibers
CA2837214C (en) A minimally invasive dermal electroporation device
WO2014123812A3 (en) Smart phone application for providing neuro/muscular electro stimulation
MX2018004330A (es) Implemento para el cuidado bucal con protrusiones conductoras.
WO2014134143A8 (en) Energy storage device assembly
WO2012134199A3 (ko) 플라즈마 발생 장치 및 기판 처리 장치
EP2593179A4 (en) DEPOSITION REMOVAL INSIDE AND OUTSIDE CIRCULATORY SYSTEMS
MX364406B (es) Distribucion jerarquica de energia.
AR098315A1 (es) Procedimiento para operar una instalación de energía eólica
CO2019005714A2 (es) Estimulación nerviosa eléctrica transcutánea usando una nueva forma de onda bifásica desequilibrada y nueva disposición de electrodos.
GB201601034D0 (en) Conductive paste,electrode and solar cell
WO2014189503A3 (en) In-situ electrolyte preparation in flow battery
WO2014131059A8 (en) Energy conversion and storage device and mobile electronic device containing same
CL2016000340A1 (es) Procedimiento para la alimentación de energía eléctrica en una red de suministro eléctrico
EP3637463A4 (en) PARALLEL ELECTRODE COMBINATION, POWER MODULE AND POWER MODULE GROUP
WO2013011474A3 (en) Nerve stimulation system
NZ709431A (en) Catheter for denervation
NZ722832A (en) Method and system for applying electric fields to multiple solar panels

Legal Events

Date Code Title Description
FB Suspension of granting procedure