AR081638A1 - Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del vih - Google Patents

Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del vih

Info

Publication number
AR081638A1
AR081638A1 ARP110101945A ARP110101945A AR081638A1 AR 081638 A1 AR081638 A1 AR 081638A1 AR P110101945 A ARP110101945 A AR P110101945A AR P110101945 A ARP110101945 A AR P110101945A AR 081638 A1 AR081638 A1 AR 081638A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
group
coor2
cycloalkyl
Prior art date
Application number
ARP110101945A
Other languages
English (en)
Spanish (es)
Inventor
Alicia Regueiro-Ren
Zheng Liu
Jacob Swidorski
Nicholas A Meanwell
Sing-Yuen Sit
Jie Yuen-Chen
Yan Chen
Ny Sin
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR081638A1 publication Critical patent/AR081638A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ARP110101945A 2010-06-04 2011-06-03 Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del vih AR081638A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35133210P 2010-06-04 2010-06-04

Publications (1)

Publication Number Publication Date
AR081638A1 true AR081638A1 (es) 2012-10-10

Family

ID=44627254

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110101945A AR081638A1 (es) 2010-06-04 2011-06-03 Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del vih

Country Status (20)

Country Link
US (1) US8802661B2 (OSRAM)
EP (1) EP2576586B1 (OSRAM)
JP (1) JP5755731B2 (OSRAM)
CN (1) CN102985438B (OSRAM)
AR (1) AR081638A1 (OSRAM)
BR (1) BR112012030810A2 (OSRAM)
CA (1) CA2801491C (OSRAM)
DK (1) DK2576586T3 (OSRAM)
EA (1) EA026140B1 (OSRAM)
ES (1) ES2548905T3 (OSRAM)
HR (1) HRP20150977T1 (OSRAM)
HU (1) HUE026662T2 (OSRAM)
MX (1) MX2012013628A (OSRAM)
PL (1) PL2576586T3 (OSRAM)
PT (1) PT2576586E (OSRAM)
RS (1) RS54239B1 (OSRAM)
SI (1) SI2576586T1 (OSRAM)
SM (1) SMT201500272B (OSRAM)
TW (1) TW201201792A (OSRAM)
WO (1) WO2011153319A1 (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS54352B1 (sr) * 2011-01-31 2016-02-29 Bristol-Myers Squibb Company C-28 amini c-3 modifikovanih derivata betulinske kiseline kao inhibitori sazrevanja hiv-a
US8846647B2 (en) * 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
BR112014006559A2 (pt) 2011-09-21 2017-03-28 Bristol Myers Squibb Co derivados do ácido betulínico com atividade antiviral
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
SG11201505639SA (en) * 2013-02-06 2015-08-28 Bristol Myers Squibb Co C-19 modified triterpenoids with hiv maturation inhibitory activity
MX2015010354A (es) 2013-02-25 2015-10-09 Squibb Bristol Myers Co Derivados de acido betulinico modificados con aquilo c-3 y alquenilo utiles en el tratamiento de virus de inmunodeficiencia humana (vih).
PL3129392T3 (pl) 2014-04-11 2021-04-06 VIIV Healthcare UK(No.4) Limited Triterpenoidy o aktywności hamującej dojrzewanie hiv, podstawione w pozycji 3 niearomatycznym pierścieniem zawierającym podstawnik fluorowcoalkilowy
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
US10047118B2 (en) 2014-11-14 2018-08-14 VIIV Healthcare UK (No.5) Limited C17-aryl substituted betulinic acid analogs
US9969767B2 (en) 2014-11-14 2018-05-15 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
CA2993758A1 (en) 2015-07-28 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
WO2017017609A1 (en) 2015-07-28 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
AU2016327169A1 (en) * 2015-09-24 2018-04-12 Glaxosmithkline Intellectual Property (No.2) Limited Compounds with hiv maturation inhibitory activity
EP3405474A1 (en) 2016-01-20 2018-11-28 Glaxosmithkline Intellectual Property (No. 2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018002849A1 (en) * 2016-06-30 2018-01-04 VIIV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
EP4321164A3 (en) 2018-04-24 2024-04-17 ViiV Healthcare UK (No.5) Limited Compounds with hiv maturation inhibitory activity
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
US10343997B1 (en) 2018-12-04 2019-07-09 King Saud University Ursolic acid derivatives

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US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
PT1068219E (pt) * 1998-03-02 2007-03-30 Univ North Carolina Derivados acilados de betulina e de di-hidrobetulina, sua preparação e sua utilização
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20040131629A1 (en) * 2002-09-26 2004-07-08 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
MXPA06010592A (es) 2004-03-17 2007-06-12 Panacos Pharmaceuticals Inc Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico.
WO2005112929A2 (en) * 2004-05-20 2005-12-01 Cornell Research Foundation, Inc. Anti-hiv-1 activity of betulinol derivatives
US7282521B2 (en) * 2004-05-24 2007-10-16 University Of North Carolina At Chapel Hill Anti-retroviral moronic acid derivatives
TW200628161A (en) * 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
US20070197646A1 (en) * 2006-02-21 2007-08-23 Achillion Pharmaceuticals, Inc. Substituted taraxastanes useful for treating viral infections
WO2008097341A2 (en) * 2006-07-26 2008-08-14 Myriad Genetics, Inc. Antiviral compounds and use thereof
WO2008127364A2 (en) * 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
US20110144069A1 (en) 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
WO2009020732A1 (en) * 2007-08-03 2009-02-12 Advanced Life Sciences, Inc. Lupane-type triterpenoids modified at 30-position and analogues thereof
WO2009042166A1 (en) 2007-09-25 2009-04-02 Panacos Pharmaceuticals, Inc. Liquid bevirimat dosage forms for oral administration
EP2257567A1 (en) 2008-02-14 2010-12-08 Virochem Pharma Inc. Novel 17 beta lupane derivatives
WO2009114083A2 (en) 2008-03-03 2009-09-17 Panacos Pharmaceuticals, Inc. Determinants of antiviral response
HUE033288T2 (en) * 2008-04-18 2017-11-28 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: C-17 homologated oleic acid derivatives
EA201290632A1 (ru) * 2010-02-11 2013-03-29 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Производные бетулина

Also Published As

Publication number Publication date
PT2576586E (pt) 2015-10-23
PL2576586T3 (pl) 2016-01-29
TW201201792A (en) 2012-01-16
US20120142653A1 (en) 2012-06-07
HRP20150977T1 (hr) 2015-10-09
CN102985438A (zh) 2013-03-20
HUE026662T2 (en) 2016-06-28
EP2576586B1 (en) 2015-08-12
EA026140B1 (ru) 2017-03-31
US8802661B2 (en) 2014-08-12
DK2576586T3 (en) 2015-11-23
ES2548905T3 (es) 2015-10-21
SI2576586T1 (sl) 2015-11-30
EP2576586A1 (en) 2013-04-10
CA2801491A1 (en) 2011-12-08
MX2012013628A (es) 2012-12-17
CN102985438B (zh) 2016-05-18
SMT201500272B (it) 2016-01-08
CA2801491C (en) 2018-01-23
EA201270800A1 (ru) 2013-04-30
JP5755731B2 (ja) 2015-07-29
RS54239B1 (sr) 2015-12-31
BR112012030810A2 (pt) 2019-09-24
WO2011153319A1 (en) 2011-12-08
JP2013527243A (ja) 2013-06-27

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Legal Events

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FA Abandonment or withdrawal