AR080841A1 - Derivados de isoxazolina sustituida; composiciones veterinarias que los comprenden y su uso en el tratamiento de parasitos en animales - Google Patents

Derivados de isoxazolina sustituida; composiciones veterinarias que los comprenden y su uso en el tratamiento de parasitos en animales

Info

Publication number
AR080841A1
AR080841A1 ARP110101163A ARP110101163A AR080841A1 AR 080841 A1 AR080841 A1 AR 080841A1 AR P110101163 A ARP110101163 A AR P110101163A AR P110101163 A ARP110101163 A AR P110101163A AR 080841 A1 AR080841 A1 AR 080841A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
cyano
cycloalkyl
animals
Prior art date
Application number
ARP110101163A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR080841A1 publication Critical patent/AR080841A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Derivado de isooxazolina o una sal aceptable desde el punto de vista veterinario del mismo, con actividad parasiticida, composiciones del mismo, y su uso como un parasiticida en animales o pájaros. Reivindicacion 1: Un compuesto de formula (1) o una sal aceptable desde el punto de vista veterinario del mismo, en la que cada uno de R1a, R1b y R1c se selecciona independientemente entre halogeno, ciano, alquilo C1-8, haloalquilo C1-6 y haloalcoxi C1-6, y cada R1 puede ser idéntico o diferente entre sí; R2 es hidrogeno, halo, ciano, alquilo C1-6, haloalquilo C1-6 o alcoxi C1-6, haloalcoxi C1-6, cicloalquilo C3-6, en la que n es un numero entero 1, 2 o 3, y cuando n es 2 o 3, cada R2 puede ser idéntico o diferente entre sí; R3 se selecciona entre alquilo C1-8, alquil C0-3-cicloalquilo C3-6, alquil C1-6-OR4 o alquil C1-6C(O)NRaRb, en la que el alquilo C1-8 y el alquil C0-3-cicloalquilo C3-6 están opcionalmente sustituidos con al menos un sustituyente seleccionado entre halo, ciano, hidroxilo y S(O)pR4; R4 es alquilo C1-6 o haloalquilo C1-6; Ra es hidrogeno o alquilo C1-6; Rb es hidrogeno, alquilo C1-6, haloalquilo C1-6, alquil C0-4-cicloalquilo C3-6 o alquil C1-3Het, en el que Het es un anillo monocíclico aromático de 5 o 6 miembros que contienen al menos un heteroátomo seleccionado entre N, O o S, y el Het puede estar opcionalmente sustituido con al menos un sustituyente seleccionado entre halo, ciano, alquilo C1-6 y haloalquilo C1-6 y p es el numero entero 0, 1 o 2.
ARP110101163A 2010-04-08 2011-04-07 Derivados de isoxazolina sustituida; composiciones veterinarias que los comprenden y su uso en el tratamiento de parasitos en animales AR080841A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32214410P 2010-04-08 2010-04-08
US201161431107P 2011-01-10 2011-01-10

Publications (1)

Publication Number Publication Date
AR080841A1 true AR080841A1 (es) 2012-05-09

Family

ID=44169107

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110101163A AR080841A1 (es) 2010-04-08 2011-04-07 Derivados de isoxazolina sustituida; composiciones veterinarias que los comprenden y su uso en el tratamiento de parasitos en animales

Country Status (10)

Country Link
US (1) US20110251247A1 (es)
EP (1) EP2556060A1 (es)
JP (1) JP2013523805A (es)
CN (1) CN102933563A (es)
AR (1) AR080841A1 (es)
AU (1) AU2011236510A1 (es)
CA (1) CA2794428A1 (es)
CL (1) CL2012002770A1 (es)
MX (1) MX2012011549A (es)
WO (1) WO2011124998A1 (es)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3013000C (en) 2008-12-19 2022-12-13 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
SG185524A1 (en) 2010-05-12 2012-12-28 Vertex Pharma Compounds useful as inhibitors of atr kinase
EP2568984A1 (en) 2010-05-12 2013-03-20 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
CA2798760A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as inhibitors of atr kinase
EP2569287B1 (en) 2010-05-12 2014-07-09 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
EP2569286B1 (en) 2010-05-12 2014-08-20 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
WO2011143419A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Pyrazines useful as inhibitors of atr kinase
EP2585468A1 (en) 2010-06-23 2013-05-01 Vertex Pharmaceuticals Incorporated Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
WO2012089622A2 (en) 2010-12-27 2012-07-05 Intervet International B.V. Topical localized isoxazoline formulation
JP2014510151A (ja) 2011-04-05 2014-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ（ｔｒａｋｉｎａｓｅ）阻害剤として有用なアミノピラジン化合物
BR112013030570A2 (pt) * 2011-05-31 2016-08-16 Sumitomo Chemical Co agente para o controle de ectoparasitas de animais
JP2014522818A (ja) 2011-06-22 2014-09-08 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
US8822469B2 (en) 2011-06-22 2014-09-02 Vertex Pharmaceuticals Incorporated Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
EP2723746A1 (en) 2011-06-22 2014-04-30 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
EP2751088B1 (en) 2011-09-30 2016-04-13 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US8853217B2 (en) 2011-09-30 2014-10-07 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
CA2850564A1 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013049726A2 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Processes for making compounds useful as inhibitors of atr kinase
CA2850491C (en) 2011-09-30 2020-10-27 Vertex Pharmaceuticals Incorporated Treating pancreatic cancer and non-small cell lung cancer with atr inhibiors
US8841450B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
WO2013071090A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
JP2015502925A (ja) 2011-11-09 2015-01-29 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用なピラジン化合物
EP2776429A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013071088A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
AU2013217633B2 (en) 2012-02-06 2017-01-12 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
AU2013245011B2 (en) 2012-04-04 2017-11-23 Intervet International B.V. Solid oral pharmaceutical compositions for isoxazoline compounds
MX358818B (es) 2012-04-05 2018-09-05 Vertex Pharma Compuestos utiles como inhibidores de cinasa ataxia telangiectasia mutada y rad3 relacionados (atr) y terapias de combinacion de estos.
AU2013259847B2 (en) 2012-05-09 2015-09-03 Zoetis Services Llc Azetidine derivatives as antiparasitic agents
WO2014055756A1 (en) 2012-10-04 2014-04-10 Vertex Pharmaceuticals Incorporated Method for measuring atr inhibition mediated increases in dna damage
US8912198B2 (en) 2012-10-16 2014-12-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US9532946B2 (en) 2012-11-20 2017-01-03 Intervet Inc. Manufacturing of semi-plastic pharmaceutical dosage units
ES2946360T3 (es) 2012-12-07 2023-07-17 Vertex Pharma Pirazolo[1,5-a]pirimidinas útiles como inhibidores de ATR quinasa para el tratamiento de enfermedades de cáncer
WO2014143240A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
EP3063144B1 (en) 2013-11-01 2021-09-08 Boehringer Ingelheim Animal Health USA Inc. Antiparasitic and pesticidal isoxazoline compounds
RU2687276C2 (ru) 2013-12-06 2019-05-13 Вертекс Фармасьютикалз Инкорпорейтед Соединения, пригодные для использования в качестве ингибиторов atr киназы
EP3131398B1 (en) 2014-04-17 2019-10-23 Boehringer Ingelheim Animal Health USA Inc. Use of malononitrile compounds for protecting animals from parasites
LT3152212T (lt) 2014-06-05 2020-05-11 Vertex Pharmaceuticals Inc. Radioaktyviai žymėti 2-amino-6-fluor-n-[5-fluor-piridin-il]- pirazolo[1,5-a]pirimidin-3-karboksamido junginio dariniai, naudingi kaip atr kinazės inhibitoriai, minėto junginio gamybos būdas ir jo skirtingos kietos formos
SG11201610500WA (en) 2014-06-17 2017-01-27 Vertex Pharma Method for treating cancer using a combination of chk1 and atr inhibitors
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
BR112017024773A2 (pt) 2015-05-20 2018-11-06 Merial, Inc. compostos depsipeptídeos anti-helmínticos
WO2016207234A1 (en) 2015-06-23 2016-12-29 Intervet International B.V. Isoxazoline solution containing vitamin e for use with sanitized drinking water
CA3000684A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
KR20180095809A (ko) 2015-11-11 2018-08-28 인사이클 세라퓨틱스, 인코포레이티드 α4β7 인테그린을 표적으로 하는 고리형 펩타이드
AU2017344097A1 (en) 2016-10-14 2019-05-02 Boehringer Ingelheim Animal Health USA Inc. Pesticidal and parasiticidal vinyl isoxazoline compounds
ES2884107T3 (es) 2016-11-11 2021-12-10 Zealand Pharma As Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7
WO2018093920A1 (en) 2016-11-16 2018-05-24 Merial, Inc. Anthelmintic depsipeptide compounds
CA3062385A1 (en) 2017-05-10 2018-11-15 Encycle Therapeutics, Inc. Homodetic cyclic peptides targeting a4s7 1ntegrin
US11589586B2 (en) 2017-08-14 2023-02-28 Boehringer Ingelheim Animal Health USA Inc. Pesticidal and parasiticidal pyrazole-isoxazoline compounds
UA127456C2 (uk) 2017-11-07 2023-08-30 Інтервет Інтернешнл Б.В. Ін'єкційна ізоксазолінова фармацевтична композиція та її застосування
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
US20220048903A1 (en) 2018-07-09 2022-02-17 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic Heterocyclic Compounds
EP3883648A1 (en) 2018-11-20 2021-09-29 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
WO2020191091A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
EP3962448A1 (en) 2019-05-03 2022-03-09 Intervet International B.V. Injectable pharmaceutical compositions and uses thereof
AU2020404003A1 (en) 2019-12-16 2022-05-26 Intervet International B.V. Parasite control in ruminants
WO2021122521A1 (en) 2019-12-16 2021-06-24 Intervet International B.V. Composition for lice control in poultry
EP4075981A1 (en) 2019-12-16 2022-10-26 Intervet International B.V. Composition for lice control
PT4153133T (pt) 2020-05-20 2024-01-12 Intervet Int Bv Composições farmacêuticas injetáveis e utilizações das mesmas
BR112022024156A2 (pt) 2020-05-29 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Compostos heterocílicos antelmínticos
WO2022162016A1 (en) 2021-01-27 2022-08-04 Intervet International B.V. Cyclopropylamide compounds against parasites in fish
US20240116854A1 (en) 2021-01-27 2024-04-11 Intervet Inc. Cyclopropylamide compounds against parasites in fish
BR112023016031A2 (pt) 2021-02-11 2023-12-05 Basf Se Compostos de fórmula i, composições agrícolas, métodos para combater ou controlar pragas invertebradas, para proteger plantas em crescimento e para tratar ou proteger um animal e semente
EP4043444A1 (en) 2021-02-11 2022-08-17 Basf Se Substituted isoxazoline derivatives
EP4351341A1 (en) 2021-06-11 2024-04-17 Intervet International B.V. Tick control methods
BR112023027372A2 (pt) 2021-06-25 2024-03-12 Intervet Int Bv Composições veterinárias palatáveis
US20230312207A1 (en) 2022-02-17 2023-10-05 Boehringer Ingelheim Vetmedica Gmbh Method and system for providing a fluid product mailer
WO2024047241A1 (en) 2022-09-02 2024-03-07 Intervet International B.V. Treatment of fasciolosis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
JP4549021B2 (ja) 2001-03-30 2010-09-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 ベンゼン化合物およびその塩
JP4451849B2 (ja) 2003-11-28 2010-04-14 日本曹達株式会社 アリール複素環誘導体および農園芸用殺菌剤および殺虫剤
GB0329314D0 (en) 2003-12-18 2004-01-21 Pfizer Ltd Substituted arylpyrazoles
KR101197482B1 (ko) 2004-03-05 2012-11-09 닛산 가가쿠 고교 가부시키 가이샤 이속사졸린 치환 벤즈아미드 화합물 및 유해생물 방제제
DE102004030753A1 (de) * 2004-06-25 2006-01-19 Bayer Cropscience Ag 3'-Alkoxy spirocyclische Tetram- und Tretronsäuren
CA2621228C (en) 2005-09-02 2014-05-27 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and pesticide
WO2007105814A1 (ja) 2006-03-10 2007-09-20 Nissan Chemical Industries, Ltd. 置換イソキサゾリン化合物及び有害生物防除剤
JP2008239611A (ja) 2007-02-27 2008-10-09 Nissan Chem Ind Ltd イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
RU2009141185A (ru) * 2007-04-10 2011-05-20 Байер КропСайенс АГ (DE) Инсектицидные производные арилизоксазолина
JP2008260691A (ja) * 2007-04-10 2008-10-30 Bayer Cropscience Ag 殺虫性アリールイソオキサゾリン誘導体
AU2009294050B2 (en) * 2008-09-18 2011-11-17 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and pest control agent

Also Published As

Publication number Publication date
AU2011236510A1 (en) 2012-10-11
WO2011124998A1 (en) 2011-10-13
MX2012011549A (es) 2013-01-29
CN102933563A (zh) 2013-02-13
CA2794428A1 (en) 2011-10-13
CL2012002770A1 (es) 2013-03-01
JP2013523805A (ja) 2013-06-17
EP2556060A1 (en) 2013-02-13
US20110251247A1 (en) 2011-10-13

Similar Documents

Publication Publication Date Title
AR080841A1 (es) Derivados de isoxazolina sustituida; composiciones veterinarias que los comprenden y su uso en el tratamiento de parasitos en animales
CO2017005790A2 (es) Derivados heterocíclicos con sustituyentes que contienen azufre activos como plaguicidas
CR20140045A (es) Compuestos de n-tio-antranilamida y sus usos como plaguicidas
PE20180603A1 (es) Derivados de triazol, sus intermediarios y su utilizacion como fungicidas
AR083081A1 (es) Isoxazolin oximas como agentes antiparasitarios
PE20181094A1 (es) Derivados heterociclicos condensados sustituidos por 2-(het)arilo como pesticidas
CU20120100A7 (es) Compuesto heterocíclico conteniendo nitrógeno y fungicida para el uso en agricultura y jardinería
AR066583A1 (es) Derivados de 3,3-espiroindolinona
CL2011001389A1 (es) Compuestos derivados de isoxazolina; composicion que comprende a uno de los compuestos; y uso de los compuestos en el control de parasitos.
CR11311A (es) Composiciones y metodos para controlar nematodos
CO6501189A2 (es) Derivados de oxazina y su uso en el tratamiento de los trastornos neurológicos
AR060401A1 (es) Derivados de cromen-2-ona
AR087467A1 (es) Compuesto heterociclico fusionado y su uso para el control de plagas
AR081628A1 (es) 5-fluoro-1h-pirazolopiridinas sustituidas y su uso
UY29177A1 (es) Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
CO6852096A2 (es) Métodos plaguicidasque utilizan compuestos de 3-piridil tiazol sustituidos y derivados para combatir las plagas de animales i
UY33070A (es) Compuestos insecticidas basados en derivados de isoxazolina
AR075635A1 (es) N-alcoxiamidas de 6-(fenil sustituido)-4-aminopicolinatos y 2-(fenil sustituido)-6-amino-4-pirimidina carboxilatos, su uso como herbicidas selectivos para las cosechas y proceso de preparacion de dichos compuestos
CR10611A (es) Isoxazolinas insecticidas
ECSP088149A (es) 3-acilaminobenzanilidas insecticidas
AR074109A1 (es) Pirrolidinas heterociclicas agonistas de receptores de la melanocortina, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento de la obesidad, diabetes y disfuncion erectil.
CO6341529A2 (es) Composicion fungicida y metodo para el control de las enfermedades de las plantas
ECSP18024565A (es) Benzamidas sustituidas con isoxazolinas y análalogos como insecticidas
ECSP11010901A (es) Compuestos de amida útiles en terapia
AR072184A1 (es) Derivados de oxadiazol como agonistas del receptor s1p1

Legal Events

Date Code Title Description
FA Abandonment or withdrawal