AR078734A1 - Composiciones, metodos para el tratamiento, y diagnostico de trastornos relacionados con la autoinmunidad y metodos para preparar tales composiciones - Google Patents

Composiciones, metodos para el tratamiento, y diagnostico de trastornos relacionados con la autoinmunidad y metodos para preparar tales composiciones

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Publication number
AR078734A1
AR078734A1 ARP100103877A ARP100103877A AR078734A1 AR 078734 A1 AR078734 A1 AR 078734A1 AR P100103877 A ARP100103877 A AR P100103877A AR P100103877 A ARP100103877 A AR P100103877A AR 078734 A1 AR078734 A1 AR 078734A1
Authority
AR
Argentina
Prior art keywords
ivig
body fluid
mammal
treatment
compositions
Prior art date
Application number
ARP100103877A
Other languages
English (en)
Original Assignee
Eiger Health Partners Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eiger Health Partners Llc filed Critical Eiger Health Partners Llc
Publication of AR078734A1 publication Critical patent/AR078734A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • B01D15/3809Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8822Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)

Abstract

Reivindicacion 1: Un método de mejora, tratamiento o prevencion de una enfermedad o trastorno asociados con una presencia de uno o varios autoanticuerpos en una circulacion de un mamífero, que comprende, en secuencia: (a) eliminacion de uno o varios de dichos autoanticuerpos de la circulacion de dicho mamífero; y (b) administracion a dicho mamífero de una preparacion intravenosa de inmunoglobulina (IVIG) que comprende al menos el 20% de inmunoglobulina 1 2 en una cantidad suficiente para restaurar el sistema inmune de dicho mamífero hasta homeostasis, en donde la preparacion de IVIG no contiene organismos virales detectables. Reivindicacion 31: Un método de purificacion de una inmunoglobulina intravenosa humana (IVIG) de un fluido corporal, en donde la IVIG resultante es apropiada para uso terapéutico, que comprende las etapas de: (a) remover uno o varios componentes de la vía de coagulacion del fluido corporal; (b) adicion de uno o varios alcoholes a fluido corporal para remover las proteínas no deseadas; (c) concentracion del fluido corporal en condiciones que evitan la activacion de la vía complementaria en el fluido corporal; y (d) tratamiento del fluido corporal para eliminar uno o varios contaminantes activos virales y microbianos; y (e) ensayo de la actividad de la IVIG al menos después de (d) para obtener una IVIG purificada del concentrado proteico plasmático, en donde la lVlG purificada es una lVlG altamente eficaz para el tratamiento de una o varias enfermedades o trastornos en un mamífero. Reivindicacion 43: Composiciones para mejorar, tratar o prevenir enfermedades o trastornos asociados con la presencia de uno o varios autoanticuerpos en la circulacion de un mamífero, en donde las composiciones contienen una o varias inmunoglobulinas obtenidas por medio del método de acuerdo con las reivindicaciones 31 a 42.
ARP100103877A 2009-10-22 2010-10-22 Composiciones, metodos para el tratamiento, y diagnostico de trastornos relacionados con la autoinmunidad y metodos para preparar tales composiciones AR078734A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25407209P 2009-10-22 2009-10-22
US30671810P 2010-02-22 2010-02-22

Publications (1)

Publication Number Publication Date
AR078734A1 true AR078734A1 (es) 2011-11-30

Family

ID=43898625

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100103877A AR078734A1 (es) 2009-10-22 2010-10-22 Composiciones, metodos para el tratamiento, y diagnostico de trastornos relacionados con la autoinmunidad y metodos para preparar tales composiciones

Country Status (8)

Country Link
US (2) US20110097344A1 (es)
EP (1) EP2490721A4 (es)
AR (1) AR078734A1 (es)
AU (1) AU2010310562A1 (es)
CA (1) CA2778158A1 (es)
RU (1) RU2012120620A (es)
TW (1) TW201125582A (es)
WO (1) WO2011050259A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130068691A1 (en) * 2011-08-05 2013-03-21 Henry John Smith Targeted apheresis for the treatment of rheumatoid arthritis and immune disorders
CN103257190B (zh) * 2013-04-15 2015-02-25 南京艾德凯腾生物医药有限责任公司 一种测定布洛芬/法莫替丁复方制剂含量的方法
CN106290657B (zh) * 2016-09-27 2018-07-06 海口南陆医药科技股份有限公司 一种用于检测地氯雷他定中杂质的方法
EP3431988B1 (en) * 2017-07-18 2021-03-10 CBmed GmbH Center for Biomarker Research in Medicine Method to determine the state of the humoral immune system in a patient
EP3863673A4 (en) * 2018-10-11 2023-01-11 Momenta Pharmaceuticals, Inc. TREATMENT WITH HIGHLY SIALYLATED IGG COMPOSITIONS
CN111057153B (zh) * 2019-12-06 2021-09-07 广州康盛生物科技股份有限公司 一种免疫球蛋白结合蛋白及其制备方法和应用
CN111929394B (zh) * 2020-08-25 2022-11-08 北京和合医学诊断技术股份有限公司 华法林的检测方法
CN112763625B (zh) * 2020-12-30 2022-07-15 江苏正济药业股份有限公司 一种法莫替丁及其有关物质的检测方法
WO2023235428A1 (en) 2022-05-31 2023-12-07 Lyfspn, Inc. Compositions and methods for plasmapheresis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6911204B2 (en) * 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
WO2007035857A2 (en) * 2005-09-19 2007-03-29 Palingen, Inc. Treatment of b cell diseases using anti-germline antibody binding agents
GB0819720D0 (en) * 2008-10-28 2008-12-03 Univ Birmingham Methods and products

Also Published As

Publication number Publication date
RU2012120620A (ru) 2013-11-27
US20150153357A1 (en) 2015-06-04
TW201125582A (en) 2011-08-01
WO2011050259A1 (en) 2011-04-28
CA2778158A1 (en) 2011-04-28
EP2490721A4 (en) 2013-05-15
EP2490721A1 (en) 2012-08-29
US20110097344A1 (en) 2011-04-28
AU2010310562A1 (en) 2012-06-07

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