AR078537A1 - Derivados heterociclicos de indol ligandos del receptor de estrogenos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades asociadas al sistema nervioso central, osteoporosis, canceres y otras patologias - Google Patents
Derivados heterociclicos de indol ligandos del receptor de estrogenos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades asociadas al sistema nervioso central, osteoporosis, canceres y otras patologiasInfo
- Publication number
- AR078537A1 AR078537A1 ARP100103630A ARP100103630A AR078537A1 AR 078537 A1 AR078537 A1 AR 078537A1 AR P100103630 A ARP100103630 A AR P100103630A AR P100103630 A ARP100103630 A AR P100103630A AR 078537 A1 AR078537 A1 AR 078537A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- alkynyl
- cycloalkyl
- alkenyl
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 208000001132 Osteoporosis Diseases 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- MPVDXIMFBOLMNW-UHFFFAOYSA-N chembl1615565 Chemical group OC1=CC=C2C=C(S(O)(=O)=O)C=C(S(O)(=O)=O)C2=C1N=NC1=CC=CC=C1 MPVDXIMFBOLMNW-UHFFFAOYSA-N 0.000 abstract 4
- 125000004982 dihaloalkyl group Chemical group 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004385 trihaloalkyl group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000006642 (C1-C6) cyanoalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0917575A GB0917575D0 (en) | 2009-10-07 | 2009-10-07 | Novel estrogen receptor ligands |
| GBGB1004377.6A GB201004377D0 (en) | 2010-03-16 | 2010-03-16 | Novel estrogen receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078537A1 true AR078537A1 (es) | 2011-11-16 |
Family
ID=43857210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103630A AR078537A1 (es) | 2009-10-07 | 2010-10-06 | Derivados heterociclicos de indol ligandos del receptor de estrogenos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades asociadas al sistema nervioso central, osteoporosis, canceres y otras patologias |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8710243B2 (Direct) |
| EP (1) | EP2486010B1 (Direct) |
| JP (1) | JP5687704B2 (Direct) |
| CN (1) | CN102791688B (Direct) |
| AR (1) | AR078537A1 (Direct) |
| DK (1) | DK2486010T3 (Direct) |
| ES (1) | ES2744219T3 (Direct) |
| IN (1) | IN2012DN02555A (Direct) |
| TW (1) | TW201124404A (Direct) |
| WO (1) | WO2011042473A2 (Direct) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| EP3076964A1 (en) | 2013-12-05 | 2016-10-12 | Karo Pharma AB | Estrogen receptor beta agonists for use in treating mesothelioma |
| WO2016036721A1 (en) | 2014-09-02 | 2016-03-10 | The Regents Of The University Of California | Estrogen receptor ligand treatment for neurodegenerative diseases |
| WO2016097036A1 (en) * | 2014-12-17 | 2016-06-23 | Karo Bio Ab | Estrogen receptor ligand for use in treating melanoma |
| US11624095B2 (en) | 2017-09-27 | 2023-04-11 | Case Western Reserve University | Method of quantifying HIV reservoirs by induced transcription based sequencing |
| CN111704648B (zh) * | 2020-06-23 | 2022-02-15 | 武汉大学 | 以氧桥双环庚烯类化合物为雌激素受体配体的蛋白水解靶向嵌合体化合物及制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001122855A (ja) | 1999-10-27 | 2001-05-08 | Japan Tobacco Inc | インドール化合物及びその医薬用途 |
| US20030220377A1 (en) | 2002-05-08 | 2003-11-27 | Richard Chesworth | Indole compounds and their use as estrogen agonists/antagonists |
| FR2868779B1 (fr) * | 2004-04-09 | 2008-08-22 | Pierre Fabre Medicament Sa | Procede de synthese et intermediaires de benzoxathiepines |
| ITMI20040874A1 (it) | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici ed azaindolici con azione antitumorale |
| EP1779848A1 (en) * | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases |
| CN101374808B (zh) * | 2006-01-24 | 2011-05-25 | 伊莱利利公司 | 孕酮受体的吲哚磺酰胺调节剂 |
| EP2074102A1 (en) | 2006-10-13 | 2009-07-01 | Karo Bio Ab | 2-phenyl indene derivatives useful as estrogen receptor ligands |
| EP2176209A1 (en) | 2007-07-20 | 2010-04-21 | Karo Bio Ab | Novel estrogen receptor ligands |
| GB0806656D0 (en) | 2008-04-11 | 2008-05-14 | Karobio Ab | Novel estrogen receptor ligands |
| US8367665B2 (en) | 2008-04-16 | 2013-02-05 | Karo Bio Ab | Estrogen receptor ligands |
| GB0817221D0 (en) | 2008-09-19 | 2008-10-29 | Karobio Ab | Novel estrogen receptor ligands |
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2010
- 2010-10-06 WO PCT/EP2010/064939 patent/WO2011042473A2/en not_active Ceased
- 2010-10-06 AR ARP100103630A patent/AR078537A1/es unknown
- 2010-10-06 US US13/500,471 patent/US8710243B2/en not_active Expired - Fee Related
- 2010-10-06 ES ES10762668T patent/ES2744219T3/es active Active
- 2010-10-06 JP JP2012532582A patent/JP5687704B2/ja not_active Expired - Fee Related
- 2010-10-06 CN CN201080045502.6A patent/CN102791688B/zh not_active Expired - Fee Related
- 2010-10-06 DK DK10762668.1T patent/DK2486010T3/da active
- 2010-10-06 EP EP10762668.1A patent/EP2486010B1/en not_active Not-in-force
- 2010-10-06 IN IN2555DEN2012 patent/IN2012DN02555A/en unknown
- 2010-10-06 TW TW099133973A patent/TW201124404A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2744219T3 (es) | 2020-02-24 |
| JP2013507335A (ja) | 2013-03-04 |
| CN102791688A (zh) | 2012-11-21 |
| EP2486010A2 (en) | 2012-08-15 |
| US8710243B2 (en) | 2014-04-29 |
| IN2012DN02555A (Direct) | 2015-08-28 |
| WO2011042473A2 (en) | 2011-04-14 |
| TW201124404A (en) | 2011-07-16 |
| JP5687704B2 (ja) | 2015-03-18 |
| CN102791688B (zh) | 2014-11-12 |
| EP2486010B1 (en) | 2019-06-12 |
| US20120202861A1 (en) | 2012-08-09 |
| DK2486010T3 (da) | 2019-09-23 |
| WO2011042473A3 (en) | 2011-06-03 |
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