AR074328A1 - Proceso para la fabricacion de bromuros de 3- piridilmetil amonio sustituidos - Google Patents

Proceso para la fabricacion de bromuros de 3- piridilmetil amonio sustituidos

Info

Publication number
AR074328A1
AR074328A1 ARP090104386A ARP090104386A AR074328A1 AR 074328 A1 AR074328 A1 AR 074328A1 AR P090104386 A ARP090104386 A AR P090104386A AR P090104386 A ARP090104386 A AR P090104386A AR 074328 A1 AR074328 A1 AR 074328A1
Authority
AR
Argentina
Prior art keywords
hydrogen
formula
dichlorobenzene
optionally substituted
alkyl
Prior art date
Application number
ARP090104386A
Other languages
English (en)
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of AR074328A1 publication Critical patent/AR074328A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicación 1: Un proceso para la fabricación de bromuros de 5,6-disustituido-3-piridilmetil amonio (1), en donde Q es una amina terciaria, alifática o cíclica, saturada, parcialmente no saturada o aromática; Z es hidrógeno o halógeno; Z1 es hidrógeno, halógeno, ciano o nitro; Y e Y1 son cada uno, independientemente, OR1, NR1R2 o, cuando se toman en forma conjunta, YY1 es -O-, -S- o NR3-; R1 y R2 son cada uno, independientemente, hidrógeno, alquilo C1-4, opcionalmente sustituido con alcoxi C1-4 o fenilo opcionalmente sustituido con uno a tres grupos alquilo C1-4, grupos alcoxi C1-4 o átomos de halógeno, o fenilo opcionalmente sustituido con uno a tres grupos alquilo C1-4, grupos alcoxi C1-4 o átomos de halógeno; R3 es hidrógeno o alquilo C1-4; caracterizado porque comprende las etapas de: (i) hacer reaccionar un compuesto de la fórmula (2), en donde los símbolos tienen el significado que se les otorga en la fórmula (1), con bromo en presencia de un iniciador radical en una mezcla de solvente que comprende una fase acuosa y una fase orgánica, donde la fase orgánica comprende un solvente seleccionado de 1,2-dicloroetano, clorobenceno, 1,2-diclorobenceno, 1,3-diclorobenceno, 1,4-diclorobenceno y tetraclorometano, y donde el valor de pH de la fase acuosa es de 3 a < 8, para obtener un compuesto 3-bromometil-5,6-disustituido piridina (3) en donde Y, Y1, Z y Z1 tienen los significados otorgados en la fórmula (1), y (ii) hacer reaccionar el compuesto bromo de la fórmula (3) con una base amina terciaria Q en un solvente en un rango de temperatura de 0sC a 100sC.
ARP090104386A 2008-11-13 2009-11-13 Proceso para la fabricacion de bromuros de 3- piridilmetil amonio sustituidos AR074328A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11423008P 2008-11-13 2008-11-13

Publications (1)

Publication Number Publication Date
AR074328A1 true AR074328A1 (es) 2011-01-05

Family

ID=41572415

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104386A AR074328A1 (es) 2008-11-13 2009-11-13 Proceso para la fabricacion de bromuros de 3- piridilmetil amonio sustituidos

Country Status (14)

Country Link
US (1) US9096570B2 (es)
EP (1) EP2365965B1 (es)
JP (1) JP5713914B2 (es)
CN (1) CN102245576B (es)
AR (1) AR074328A1 (es)
AU (1) AU2009315580B2 (es)
BR (1) BRPI0921882B1 (es)
IL (1) IL212808A (es)
MX (1) MX2011004938A (es)
RU (1) RU2549896C2 (es)
TW (1) TW201029975A (es)
UA (1) UA103502C2 (es)
UY (1) UY32243A (es)
WO (1) WO2010055139A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2358678B1 (en) 2008-11-13 2015-01-14 Basf Se Process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides
CN102245577B (zh) 2008-11-13 2014-03-26 巴斯夫欧洲公司 2-[(1-氰基丙基)氨基甲酰基]-5-氯甲基烟酸及其在制备除草咪唑啉酮中的用途
WO2010066668A1 (en) 2008-12-09 2010-06-17 Basf Se Process for manufacturing 5-formyl-pyridine-2,3-dicarboxylic acid esters
CN103613535A (zh) * 2013-11-26 2014-03-05 潍坊先达化工有限公司 一种5-（甲氧基甲基）-2,3-吡啶二甲酸二甲酯的合成方法
UA125630C2 (uk) * 2016-11-21 2022-05-04 Адама Аган Лтд. Спосіб одержання метоксиметилпіридиндикарбоксилату
CN107151228A (zh) * 2017-06-25 2017-09-12 刘瑞海 一种3‑甲氧基甲基吡啶的合成方法
CN107033067A (zh) * 2017-06-25 2017-08-11 刘瑞海 一种2‑甲氧基甲基吡啶的合成方法
CN107286081A (zh) * 2017-06-26 2017-10-24 蒋潇 一种4‑甲氧基甲基吡啶的合成方法
CN109096294A (zh) * 2018-09-03 2018-12-28 周银平 吡啶化合物的制备方法
EP3782985A1 (en) 2019-08-19 2021-02-24 BASF Agrochemical Products B.V. Process for manufacturing 5-methoxymethylpyridine-2,3-dicarboxylic acid derivatives
CN113968814A (zh) * 2020-07-22 2022-01-25 帕潘纳(北京)科技有限公司 一种制备5-溴甲基-2,3-吡啶羧酸二甲酯的方法

Family Cites Families (17)

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DE3330604A1 (de) 1983-08-25 1985-03-28 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von brommethylthiophen-carbonsaeureestern
US4562257A (en) 1983-11-07 1985-12-31 American Cyanamid Company Preparation of substituted and unsubstituted 2-carbamoyl nicotinic and 3-quinolinecarboxylic acids
US4782157A (en) 1984-12-03 1988-11-01 American Cyanamid Co. Preparation of substituted and unsubstituted 2-carbamoyl nicotinic and 3-quinolinecarboxylic acids
JPH07611B2 (ja) 1986-01-24 1995-01-11 日産化学工業株式会社 ピリジン誘導体，その製造方法および除草剤
US5334576A (en) 1986-07-28 1994-08-02 American Cyanamid Company 5 (and/or 6) substituted 2-(2-imidazolin-2-yl)nicotinic acids, esters and salts, useful as herbicidal agents and novel intermediates for the preparation of said nicotinic acids, esters and salts
EP0322616A3 (en) 1987-12-31 1989-10-18 American Cyanamid Company Novel 5(and/or 6)substituted 2-(2-imidazolin-2-yl)nicotinic acids, esters and salts, useful as herbicidal agents and nivel intermediates for the preparation of said nicotinic acids, esters and salts
US5026859A (en) 1989-12-27 1991-06-25 American Cyanamid Company Alkyl esters of 5-heterocyclic-pyridine-2,3-dicarboxylic acids
US5215568A (en) 1991-10-31 1993-06-01 American Cyanamid Company Oxime derivatives of formylpyridyl imidazolinones, the herbicidal use and methods for the preparation thereof
US5288866A (en) * 1991-12-20 1994-02-22 American Cyanamid Company 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds useful for the preparation of 5- (substituted methyl)-2,3-pyridinedicarboxylic acids
CN1042333C (zh) * 1992-10-14 1999-03-03 美国氰胺公司 5,6－二取代－3－吡啶甲基卤化铵类化合物及其制备方法
EP0747360B1 (en) 1995-06-05 2001-09-19 Basf Aktiengesellschaft Improved process for the manufacture of 5-(alkoxymethyl) pyridine-2,3-dicarboxylate salt
US5892050A (en) 1998-01-28 1999-04-06 American Cyanamid Company Process for the preparation of pyridine dicarboxylate derivatives
US6339158B1 (en) * 1999-05-03 2002-01-15 American Cyanamid Co. Process for the preparation of chiral nicotinic, quinolinic or benzoic acid imidazolinone herbicides
EP2145682A1 (de) 2008-07-18 2010-01-20 Roche Diagnostics GmbH Testelement zur Analyse einer Körperflüssigkeitsprobe auf einen darin enthaltenen Analyten, Analysesystem und Verfahren zur Steuerung der Bewegung einer in einem Kanal eines Testelements enthaltenen Flüssigkeit
CN102245577B (zh) 2008-11-13 2014-03-26 巴斯夫欧洲公司 2-[(1-氰基丙基)氨基甲酰基]-5-氯甲基烟酸及其在制备除草咪唑啉酮中的用途
EP2358678B1 (en) 2008-11-13 2015-01-14 Basf Se Process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides
WO2010055042A1 (en) 2008-11-13 2010-05-20 Basf Se 2-[(1-cyanopropyl)carbamoyl]-5-methoxymethyl nicotinic acids and the use thereof in manufacturing herbicidal imidazolinones

Also Published As

Publication number Publication date
CN102245576A (zh) 2011-11-16
IL212808A0 (en) 2011-07-31
UA103502C2 (ru) 2013-10-25
TW201029975A (en) 2010-08-16
RU2549896C2 (ru) 2015-05-10
EP2365965A1 (en) 2011-09-21
AU2009315580A1 (en) 2010-05-20
AU2009315580B2 (en) 2015-06-18
RU2011123372A (ru) 2012-12-20
EP2365965B1 (en) 2019-01-09
WO2010055139A1 (en) 2010-05-20
CN102245576B (zh) 2014-11-05
IL212808A (en) 2015-10-29
JP2012508729A (ja) 2012-04-12
US20110224433A1 (en) 2011-09-15
BRPI0921882B1 (pt) 2018-02-06
MX2011004938A (es) 2011-06-06
UY32243A (es) 2010-05-31
US9096570B2 (en) 2015-08-04
BRPI0921882A2 (pt) 2015-12-29
JP5713914B2 (ja) 2015-05-07

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