AR074027A1 - Inhibicion de replicas de vih y de expresion de p-24 con elf-5a - Google Patents

Inhibicion de replicas de vih y de expresion de p-24 con elf-5a

Info

Publication number
AR074027A1
AR074027A1 ARP070101973A ARP070101973A AR074027A1 AR 074027 A1 AR074027 A1 AR 074027A1 AR P070101973 A ARP070101973 A AR P070101973A AR P070101973 A ARP070101973 A AR P070101973A AR 074027 A1 AR074027 A1 AR 074027A1
Authority
AR
Argentina
Prior art keywords
hiv
expression
seq
sec
elf
Prior art date
Application number
ARP070101973A
Other languages
English (en)
Inventor
John E Thomspon
Charles A Dinarello
Catherine Taylor
Richard S Dondero
Original Assignee
Senesco Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senesco Technologies Inc filed Critical Senesco Technologies Inc
Publication of AR074027A1 publication Critical patent/AR074027A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol

Abstract

La presente solicitud se relaciona con métodos para inhibir la replica del virus de HIV a través de siARN o polinucleotidos antisentido de eIF-5A1. La presente solicitud también expone métodos para inhibir la expresion de p24 con siARN o polinucleotidos antisentido de eIF-5A1. Reivindicacion 13: Una composicion farmacéutica para inhibir la réplica de VIH o inhibir la expresion de p24 en una célula infectada de VIH comprende un polinucleotido antisentido seleccionado de un grupo de polinucleotidos antisentido que consisten en ID SEC N°: 63, ID SEC N°: 64, ID SEC N°: 65; ID SEC N°: 25, ID SEC N°: 26, y ID SEC N°: 27.
ARP070101973A 2006-03-29 2007-05-07 Inhibicion de replicas de vih y de expresion de p-24 con elf-5a AR074027A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78680606P 2006-03-29 2006-03-29
PCT/US2007/065380 WO2007115047A2 (en) 2006-03-29 2007-03-28 Inhibition of hiv replication and expression of p24 with eif-5a

Publications (1)

Publication Number Publication Date
AR074027A1 true AR074027A1 (es) 2010-12-22

Family

ID=38576116

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101973A AR074027A1 (es) 2006-03-29 2007-05-07 Inhibicion de replicas de vih y de expresion de p-24 con elf-5a

Country Status (3)

Country Link
US (1) US20070238691A1 (es)
AR (1) AR074027A1 (es)
WO (1) WO2007115047A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007226875A1 (en) * 2006-03-20 2007-09-27 Senesco Technologies, Inc. Use of eiF-5A1 siRNA and antisense to treat sepsis or haemorrhagic shock
EP2699655A4 (en) 2011-04-18 2015-02-25 Poet Res Inc SYSTEMS AND METHODS FOR FRACTIONING VINASSE
US11718863B2 (en) 2015-11-25 2023-08-08 Poet Grain (Octane), Llc Processes for recovering products from a slurry
US11248197B2 (en) 2015-11-25 2022-02-15 Poet Grain (Octane), Llc Processes for recovering products from a corn fermentation mash
US10059966B2 (en) 2015-11-25 2018-08-28 Flint Hills Resources, Lp Processes for recovering products from a corn fermentation mash
US11730172B2 (en) 2020-07-15 2023-08-22 Poet Research, Inc. Methods and systems for concentrating a solids stream recovered from a process stream in a biorefinery

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849587A (en) * 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
WO2002081628A2 (en) * 2001-04-05 2002-10-17 Ribozyme Pharmaceuticals, Incorporated Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
JP4095895B2 (ja) * 2000-12-01 2008-06-04 マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー．ヴェー． Ｒｎａ干渉を媒介する短鎖ｒｎａ分子
WO2004078940A2 (en) * 2003-03-05 2004-09-16 Senesco Technologies, Inc. USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1
WO2005007853A2 (en) * 2003-06-06 2005-01-27 Senesco Technologies, Inc. Inhibition of apoptosis-specific elf-5a (“eif-5a1”) with antisense oligonucleotides and sirnas as anti-inflammatory therapeutics
JP2008507278A (ja) * 2004-07-20 2008-03-13 セネスコ テクノロジーズ，インコーポレイティド 炎症反応を阻害／抑制するためのアポトーシス特異的ｅＩＦ−５Ａ・ｓｉＲＮＡ及びアンチセンスポリヌクレオチドの使用

Also Published As

Publication number Publication date
WO2007115047A3 (en) 2007-12-21
WO2007115047A2 (en) 2007-10-11
US20070238691A1 (en) 2007-10-11

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