AR073654A1 - Proceso para la sintesis del (aib8,35) hglp-1(7-36) -nh2 - Google Patents
Proceso para la sintesis del (aib8,35) hglp-1(7-36) -nh2Info
- Publication number
- AR073654A1 AR073654A1 ARP090103632A ARP090103632A AR073654A1 AR 073654 A1 AR073654 A1 AR 073654A1 AR P090103632 A ARP090103632 A AR P090103632A AR P090103632 A ARP090103632 A AR P090103632A AR 073654 A1 AR073654 A1 AR 073654A1
- Authority
- AR
- Argentina
- Prior art keywords
- ala
- glu
- ser
- aib
- thr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente solicitud se relaciona con un proceso para la síntesis a gran escala del (Aib8'35)hGLP-1(7-36)-NH2 (SEC. ID. Ns:2), es decir, His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2 (SEC. ID Ns:2), que comprende química Fmoc en fase solida. Reivindicacion 2: Un proceso para la síntesis del (Aib8'35)hGLP-1(7-36)-NH2 (SEC. ID. Ns:2) de acuerdo con la reivindicacion 1, que comprende los siguientes pasos: (a) acoplar en forma sucesiva aminoácidos Fmoc, desde el C-terminal hasta el N-terminal del (Aib8,35)hGLP-1(8-35)-NH2 (SEC. ID. Ns:8), con una resina Arg protegida con cadena lateral, donde se elimina el grupo Fmoc del N-terminal después de cada paso de acoplamiento sucesivo, para obtener una resina Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Giy-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg protegida con cadena lateral (SEC ID Ns:4); (b) acoplar el Boc-His-OH protegido con cadena lateral con la resina Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Giy-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg protegida con cadena lateral (SEC. ID. Ns:4), para obtener una resina Boc-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg protegida con cadena lateral (SEC. ID. Ns:5); (c) tratar la resina Boc-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr -Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-lle-Ala-Trp-Leu-Val-Lys-Aib-Arg protegida con cadena lateral (SEC. ID. Ns:5) con un coctel de segmentacion y eliminar los grupos protectores de cadena lateral y el grupo protector del N-terminal de aquella, para obtener el (Aib8,35)hGLP-1(7-36)-NH2 crudo (SEC. ID. Ns:2); y (d) aislar y purificar el (Aib8,35)hGLp-1(7-36)-NH2 crudo (SEC. ID. Ns:2), para obtener el (Aib8,35)hGLP-1(7-36)-NH2 purificado (SEC. ID. Ns:2).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19293908P | 2008-09-22 | 2008-09-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR073654A1 true AR073654A1 (es) | 2010-11-24 |
Family
ID=42039799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090103632A AR073654A1 (es) | 2008-09-22 | 2009-09-22 | Proceso para la sintesis del (aib8,35) hglp-1(7-36) -nh2 |
Country Status (13)
Country | Link |
---|---|
US (1) | US20130030148A1 (es) |
EP (1) | EP2334316A4 (es) |
JP (1) | JP2012502992A (es) |
KR (1) | KR20110070870A (es) |
CN (1) | CN102223890B (es) |
AR (1) | AR073654A1 (es) |
AU (1) | AU2009293665A1 (es) |
BR (1) | BRPI0918993A2 (es) |
CA (1) | CA2737770A1 (es) |
EA (1) | EA201170477A1 (es) |
MX (1) | MX2011002885A (es) |
TW (1) | TW201012829A (es) |
WO (1) | WO2010033254A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110313131A1 (en) * | 2010-06-21 | 2011-12-22 | Christelle Carl | Reversed phase hplc purification of a glp-1 analogue |
WO2014077801A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification process for preparing highly pure taspoglutide |
WO2014077802A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification method of a glp-1 analogue |
MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
SG11201506804VA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of hydantoin containing peptide products |
KR102251970B1 (ko) * | 2015-05-07 | 2021-05-14 | 삼성전자 주식회사 | 풀 듀플렉스 방식을 지원하는 통신 시스템에서 자기 간섭 신호 제거 장치 및 방법 |
CN111065631B (zh) * | 2017-12-06 | 2021-10-08 | 江苏恒瑞医药股份有限公司 | 一种苯基丙酰胺类衍生物的盐及其制备方法 |
US11753440B2 (en) | 2018-06-05 | 2023-09-12 | Dsm Ip Assets B.V. | Methods for the synthesis of arginine-containing peptides |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07242696A (ja) * | 1990-08-10 | 1995-09-19 | Enichem Partecipazioni Spa | 植物病原体に対して活性な抗菌性ペプチド、その使用法およびこれに関連するスクリーニング法 |
WO1992015317A1 (en) * | 1991-03-08 | 1992-09-17 | Amylin Pharmaceuticals, Inc. | Synthetic preparation of amylin and amylin analogues |
WO2000034331A2 (en) * | 1998-12-07 | 2000-06-15 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Analogues of glp-1 |
WO2000069911A1 (en) * | 1999-05-17 | 2000-11-23 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
JP2007536214A (ja) * | 2003-12-16 | 2007-12-13 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | Glp−1類似体 |
AU2004298424A1 (en) * | 2003-12-18 | 2005-06-30 | Novo Nordisk A/S | Novel GLP-1 compounds |
US7897724B2 (en) * | 2004-10-10 | 2011-03-01 | Usv, Ltd. | Solid phase Fmoc chemistry process to prepare peptides |
US20100009907A1 (en) * | 2006-07-06 | 2010-01-14 | Amylin Pharmaceuticals, Inc. | Glucagon-Like Peptides and Uses Thereof |
-
2009
- 2009-09-21 TW TW098131812A patent/TW201012829A/zh unknown
- 2009-09-22 EP EP09814916A patent/EP2334316A4/en not_active Withdrawn
- 2009-09-22 WO PCT/US2009/005265 patent/WO2010033254A1/en active Application Filing
- 2009-09-22 CA CA2737770A patent/CA2737770A1/en not_active Abandoned
- 2009-09-22 EA EA201170477A patent/EA201170477A1/ru unknown
- 2009-09-22 MX MX2011002885A patent/MX2011002885A/es active IP Right Grant
- 2009-09-22 KR KR1020117008496A patent/KR20110070870A/ko active IP Right Grant
- 2009-09-22 US US13/120,195 patent/US20130030148A1/en not_active Abandoned
- 2009-09-22 JP JP2011527830A patent/JP2012502992A/ja active Pending
- 2009-09-22 BR BRPI0918993A patent/BRPI0918993A2/pt not_active IP Right Cessation
- 2009-09-22 CN CN200980146319.2A patent/CN102223890B/zh active Active
- 2009-09-22 AR ARP090103632A patent/AR073654A1/es not_active Application Discontinuation
- 2009-09-22 AU AU2009293665A patent/AU2009293665A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2737770A1 (en) | 2010-03-25 |
KR20110070870A (ko) | 2011-06-24 |
MX2011002885A (es) | 2011-05-31 |
US20130030148A1 (en) | 2013-01-31 |
AU2009293665A1 (en) | 2010-03-25 |
CN102223890A (zh) | 2011-10-19 |
EA201170477A1 (ru) | 2011-10-31 |
EP2334316A1 (en) | 2011-06-22 |
JP2012502992A (ja) | 2012-02-02 |
BRPI0918993A2 (pt) | 2019-09-24 |
TW201012829A (en) | 2010-04-01 |
EP2334316A4 (en) | 2013-01-09 |
CN102223890B (zh) | 2015-02-11 |
WO2010033254A8 (en) | 2012-05-24 |
WO2010033254A1 (en) | 2010-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |