AR071585A1 - 4- metil-4,5-dihidro-1h-pirazol-3-carboxamida util como antagonista de cannabinoide cb1 - Google Patents

4- metil-4,5-dihidro-1h-pirazol-3-carboxamida util como antagonista de cannabinoide cb1

Info

Publication number
AR071585A1
AR071585A1 ARP090101240A ARP090101240A AR071585A1 AR 071585 A1 AR071585 A1 AR 071585A1 AR P090101240 A ARP090101240 A AR P090101240A AR P090101240 A ARP090101240 A AR P090101240A AR 071585 A1 AR071585 A1 AR 071585A1
Authority
AR
Argentina
Prior art keywords
compound
methyl
cannabinoid
carboxamide
dihidro
Prior art date
Application number
ARP090101240A
Other languages
English (en)
Inventor
Hernandez Jose Miguel Vela
Minguez Susana Yenes
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of AR071585A1 publication Critical patent/AR071585A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se refiere también a composiciones farmacéuticas que comprenden este compuesto como principio activo, así como procedimientos e intermedios para preparar este compuesto y composiciones. El compuesto referido es un antagonista neutro de cannabinoide CB1 util en la profilaxis y el tratamiento de trastornos relacionados con la ingestion de alimentos. Reivindicacion 1: Compuesto (4S,5S)-5-(4-clorofenil)-1-(2,4-diclorofenil)-N-(cis-2, 6-dimetilpiperidin-1-il)-4-metil- 4,5-dihidro-1H-pirazol-3-carbOxamida, y sales farmacéuticamente aceptables y solvatos del mismo. Reivindicacion 5: compuesto de formula (2). Reivindicacion 6: Compuesto de formula (3) donde Z representa halo, -O-CO-R1, o -O-CO-OR1; y R1 es alquilo C1-4, arilo, o bencilo. Reivindicacion 7: Compuesto (4S,5S)-5-(4-clorofenil)-1-(2,4-diclorofenil-N-(trans-2,6-dimetilpiperidin-1-il)-4-metil- 4,5-dihidro-1H-pirazol-3-carboxamida, y sales farmacéuticamente aceptables y solvatos del mismo.
ARP090101240A 2008-04-10 2009-04-08 4- metil-4,5-dihidro-1h-pirazol-3-carboxamida util como antagonista de cannabinoide cb1 AR071585A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08384004A EP2108643A1 (en) 2008-04-10 2008-04-10 4-methyl-4, 5-dihydro-1H-pyrazole-3-carboxamide useful as a cannabinoid CB1 neutral antagonist

Publications (1)

Publication Number Publication Date
AR071585A1 true AR071585A1 (es) 2010-06-30

Family

ID=39684392

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090101240A AR071585A1 (es) 2008-04-10 2009-04-08 4- metil-4,5-dihidro-1h-pirazol-3-carboxamida util como antagonista de cannabinoide cb1

Country Status (6)

Country Link
US (1) US20110028517A1 (es)
EP (2) EP2108643A1 (es)
AR (1) AR071585A1 (es)
CL (1) CL2009000845A1 (es)
TW (1) TW200946515A (es)
WO (1) WO2009124950A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6304503B2 (ja) * 2015-10-16 2018-04-04 マツダ株式会社 車両の側部車体構造
SG11201803153RA (en) * 2015-11-16 2018-06-28 Esteve Labor Dr Oxadiazaspiro compounds for the treatment of drug abuse and addiction
CN105699582B (zh) * 2016-01-23 2017-05-03 河北科技大学 一种3‑氨基哌啶异构体的hplc检测方法
CN105510263B (zh) * 2016-01-23 2018-08-31 河北科技大学 一种3-氨基哌啶异构体的hplc分析方法
CN105675782B (zh) * 2016-01-23 2017-04-12 河北科技大学 一种3‑氨基哌啶手性纯度的分析方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200533657A (en) 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743890A1 (en) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments
US7829581B2 (en) * 2005-07-15 2010-11-09 Laboratorios Del Dr. Esteve, S.A. Prodrugs of pyrazoline compounds, their preparation and use as medicaments
EP2151234A1 (en) * 2008-07-28 2010-02-10 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion

Also Published As

Publication number Publication date
WO2009124950A2 (en) 2009-10-15
WO2009124950A3 (en) 2010-03-04
US20110028517A1 (en) 2011-02-03
TW200946515A (en) 2009-11-16
EP2108643A1 (en) 2009-10-14
CL2009000845A1 (es) 2009-08-21
EP2282997A2 (en) 2011-02-16

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