AR070076A1 - Derivados de 2-benzoil-imidazo[1,2-alfa]piridina, su preparacion y su aplicacion en terapeutica en el tratamiento de enfermedades relacionadas con los receptores nucleares nurr-1 - Google Patents
Derivados de 2-benzoil-imidazo[1,2-alfa]piridina, su preparacion y su aplicacion en terapeutica en el tratamiento de enfermedades relacionadas con los receptores nucleares nurr-1Info
- Publication number
- AR070076A1 AR070076A1 ARP080105781A ARP080105781A AR070076A1 AR 070076 A1 AR070076 A1 AR 070076A1 AR P080105781 A ARP080105781 A AR P080105781A AR P080105781 A ARP080105781 A AR P080105781A AR 070076 A1 AR070076 A1 AR 070076A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- group
- hydroxy
- hydrogen atom
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Utilizacion en terapéutica y composiciones. Reivindicacion 1: Compuestos de formula (1) en la que: X representa un grupo fenilo opcionalmente sustituido por uno o varios átomos o grupos seleccionados independientemente unos de los otros entre los átomos o grupos siguientes: halogeno, alquilo C1-6, alcoxi C1-6, hidroxi, amino, NRaRb, estando los grupos alquilo C1-6 y alcoxi C1-6 opcionalmente sustituidos por uno o varios átomos de halogeno; R2 representa un grupo heterocíclico opcionalmente sustituido por uno o varios grupos seleccionados independientemente unos de los otros entre los átomos o grupos siguientes: hidroxi, halogeno, alcoxi C1-6, alquilo C1-6 opcionalmente sustituido por uno o varios hidroxi, NRcRd, -CO-R5, -CO-NR6R7, -CO-O-R8, -NR9-CO-R10, ciano, un grupo oxido; R1 representa un átomo de hidrogeno, un halogeno, un grupo alcoxi C1-6, alquilo C1-6, hidroxi, amino, los grupos alquilo C1-6 y alcoxi C1-6 que opcionalmente pueden sustituirse por uno o varios átomos o grupos halogeno, hidroxi, amino, alcoxi C1-6; R3 representa un átomo de hidrogeno, un grupo alquilo C1-6, un átomo de halogeno o un grupo hidroxi; R4 representa un átomo de hidrogeno, o un átomo de halogeno; R5 representa un átomo de hidrogeno o un grupo alquilo C1-6; R6 y R7, idénticos o diferentes, representan un átomo de hidrogeno, un grupo alquilo C1-6 o forman con el átomo de nitrogeno que les lleva un ciclo de 4 a 7 eslabones incluyendo opcionalmente otro heteroátomo seleccionado de entre N, O o S; R8 representa un grupo alquilo C1-6; R9 y R10, idénticos o diferentes, representan un átomo de hidrogeno o un grupo alquilo C1-6; Ra representa un alquilo C1-6; Rb, Rc y Rd representan un H o un alquilo C1-6; en estado de base o de sal de adicion a un ácido. Reivindicacion 14: Compuesto fenil[6-(4,4,5,5-tetrametil-1,3,2-dioxaborolan-2-il)imidazo[1,2-a]piridin-2-il]metanona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800007A FR2925905B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES DE 2-BENZOYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070076A1 true AR070076A1 (es) | 2010-03-10 |
Family
ID=39712667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105781A AR070076A1 (es) | 2008-01-02 | 2008-12-30 | Derivados de 2-benzoil-imidazo[1,2-alfa]piridina, su preparacion y su aplicacion en terapeutica en el tratamiento de enfermedades relacionadas con los receptores nucleares nurr-1 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20100317687A1 (es) |
| EP (1) | EP2260033B1 (es) |
| JP (1) | JP2011508761A (es) |
| KR (1) | KR20100092040A (es) |
| CN (1) | CN101910174A (es) |
| AR (1) | AR070076A1 (es) |
| AT (1) | ATE534647T1 (es) |
| AU (1) | AU2008352729B8 (es) |
| BR (1) | BRPI0821993A2 (es) |
| CA (1) | CA2710801A1 (es) |
| CL (1) | CL2008003930A1 (es) |
| FR (1) | FR2925905B1 (es) |
| IL (1) | IL206665A0 (es) |
| RU (1) | RU2442785C1 (es) |
| TW (1) | TW200942538A (es) |
| UY (1) | UY31591A1 (es) |
| WO (1) | WO2009112652A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2993564B1 (fr) * | 2012-07-20 | 2014-08-22 | Metabrain Res | Derives d'imidazopyridine utiles dans le traitement du diabete |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2638161B1 (fr) * | 1988-10-24 | 1991-01-11 | Centre Nat Rech Scient | Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| GB9919778D0 (en) * | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| BRPI0409241A (pt) * | 2003-04-10 | 2006-03-28 | Pfizer | compostos bicìclicos como antagonistas do receptor de nr2b, composições farmacêuticas compreendendo os mesmos e seu uso |
| JPWO2005085214A1 (ja) * | 2004-03-05 | 2008-01-17 | 萬有製薬株式会社 | ジアリール置換複素５員環誘導体 |
| FR2903107B1 (fr) | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2903105A1 (fr) * | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
-
2008
- 2008-01-02 FR FR0800007A patent/FR2925905B1/fr not_active Expired - Fee Related
- 2008-12-30 UY UY31591A patent/UY31591A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003930A patent/CL2008003930A1/es unknown
- 2008-12-30 AR ARP080105781A patent/AR070076A1/es unknown
- 2008-12-31 RU RU2010132243/04A patent/RU2442785C1/ru not_active IP Right Cessation
- 2008-12-31 TW TW097151688A patent/TW200942538A/zh unknown
- 2008-12-31 AT AT08873262T patent/ATE534647T1/de active
- 2008-12-31 CA CA2710801A patent/CA2710801A1/fr not_active Abandoned
- 2008-12-31 WO PCT/FR2008/001837 patent/WO2009112652A1/fr active Application Filing
- 2008-12-31 JP JP2010541086A patent/JP2011508761A/ja not_active Withdrawn
- 2008-12-31 KR KR1020107014644A patent/KR20100092040A/ko not_active Application Discontinuation
- 2008-12-31 BR BRPI0821993-1A patent/BRPI0821993A2/pt not_active IP Right Cessation
- 2008-12-31 AU AU2008352729A patent/AU2008352729B8/en not_active Ceased
- 2008-12-31 EP EP08873262A patent/EP2260033B1/fr active Active
- 2008-12-31 CN CN2008801238382A patent/CN101910174A/zh active Pending
-
2010
- 2010-06-28 IL IL206665A patent/IL206665A0/en unknown
- 2010-07-01 US US12/828,379 patent/US20100317687A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011508761A (ja) | 2011-03-17 |
| EP2260033A1 (fr) | 2010-12-15 |
| CL2008003930A1 (es) | 2010-02-12 |
| RU2442785C1 (ru) | 2012-02-20 |
| CN101910174A (zh) | 2010-12-08 |
| UY31591A1 (es) | 2009-08-03 |
| AU2008352729B8 (en) | 2011-04-28 |
| EP2260033B1 (fr) | 2011-11-23 |
| FR2925905B1 (fr) | 2010-11-05 |
| IL206665A0 (en) | 2010-12-30 |
| KR20100092040A (ko) | 2010-08-19 |
| BRPI0821993A2 (pt) | 2015-06-23 |
| FR2925905A1 (fr) | 2009-07-03 |
| ATE534647T1 (de) | 2011-12-15 |
| CA2710801A1 (fr) | 2009-09-17 |
| US20100317687A1 (en) | 2010-12-16 |
| AU2008352729B2 (en) | 2011-03-31 |
| TW200942538A (en) | 2009-10-16 |
| AU2008352729A1 (en) | 2009-09-17 |
| WO2009112652A1 (fr) | 2009-09-17 |
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