AR069007A1 - Complejos de los dominios de trpc y sestd1 y metodos y usos que envuelven los mismos - Google Patents
Complejos de los dominios de trpc y sestd1 y metodos y usos que envuelven los mismosInfo
- Publication number
- AR069007A1 AR069007A1 ARP080104623A ARP080104623A AR069007A1 AR 069007 A1 AR069007 A1 AR 069007A1 AR P080104623 A ARP080104623 A AR P080104623A AR P080104623 A ARP080104623 A AR P080104623A AR 069007 A1 AR069007 A1 AR 069007A1
- Authority
- AR
- Argentina
- Prior art keywords
- protein
- trpc
- disease
- test system
- sestd1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Complejo aislado que comprende una primera proteína que comprende o consiste en un clásico canal de potencial de receptor transitorio (TRPC) o una variante funcionalmente activa del mismo y una segunda proteína que comprende o consiste en el dominio de la primera espectrina (Spec 1) de SEC14 y los dominios 1 de espectrina (SESTD1), un sistema de prueba que comprende la primera proteína y la segunda proteína así como los medios para detectar la interacción de la primera y la segunda proteína, un método para cribar un modulador de TRPC usando el sistema y el uso del sistema de prueba para la identificación de un modulador de TRPC. Reivindicación 18: El método de cualquiera de las reivindicaciones 10 a 17, en donde el método se usa para cribar un medicamento para prevenir y/o tratar una enfermedad que envuelva la disfunción endotelial. Reivindicación 19: El método de cualquiera de las reivindicaciones 10 a 17, en donde el método se usa para cribar un medicamento para prevenir y/o tratar una enfermedad cardiovascular, hipertrofia cardiaca, fracaso del corazón, isquemia, hiperplasia neointima, cardiomiopatía dilatada idiopática, hipertensión, síndrome coronario, fracaso del corazón, fracaso del riñón, trombosis, enfermedad respiratoria crónica, asma, trastorno pulmonar obstructivo crónico, hipertensión pulmonar idiopática, vasoconstricción pulmonar hipóxica aguda, enfermedad oclusiva inflamatoria y aterosclerosis. Reivindicación 20: El uso de un sistema de prueba según la reivindicación 9 para la identificación de un modulador de TRPC.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07291300A EP2053059A1 (en) | 2007-10-26 | 2007-10-26 | Complexes of TRPC domains and SESTD1 domains and methods and uses involving the same |
Publications (1)
Publication Number | Publication Date |
---|---|
AR069007A1 true AR069007A1 (es) | 2009-12-23 |
Family
ID=39232772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080104623A AR069007A1 (es) | 2007-10-26 | 2008-10-23 | Complejos de los dominios de trpc y sestd1 y metodos y usos que envuelven los mismos |
Country Status (12)
Country | Link |
---|---|
US (1) | US20100330697A1 (es) |
EP (2) | EP2053059A1 (es) |
JP (1) | JP2011501757A (es) |
KR (1) | KR20100076992A (es) |
CN (1) | CN101848933A (es) |
AR (1) | AR069007A1 (es) |
AU (1) | AU2008315951A1 (es) |
CA (1) | CA2702508A1 (es) |
IL (1) | IL205218A0 (es) |
MX (1) | MX2010004097A (es) |
TW (1) | TW200934789A (es) |
WO (1) | WO2009052971A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103954770B (zh) * | 2014-04-25 | 2015-09-30 | 江南大学 | EVs-TRPC5在检测乳腺癌耐药程度中的应用 |
CN110777186A (zh) * | 2019-10-29 | 2020-02-11 | 浙江树人学院(浙江树人大学) | Trpc1对高糖培养的内皮细胞功能影响的实验方法 |
CN116891523B (zh) * | 2023-05-24 | 2024-05-17 | 深圳晶蛋生物医药科技有限公司 | 一种trpm3截短体、包含其的细胞系及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI963989A (fi) | 1996-10-04 | 1998-04-05 | Wallac Oy | Homogeenisiä määritysmenetelmiä, jotka perustuvat luminesenssienergiasiirtoon |
WO2001073014A1 (en) * | 2000-03-24 | 2001-10-04 | Merck Patent Gmbh | Human survivin interacting protein 1 (sip-1) |
US7858322B2 (en) * | 2003-12-23 | 2010-12-28 | Nono, Inc. | Method of determining inhibition of binding to TRPM7 protein |
-
2007
- 2007-10-26 EP EP07291300A patent/EP2053059A1/en not_active Ceased
-
2008
- 2008-10-14 KR KR1020107009065A patent/KR20100076992A/ko not_active Application Discontinuation
- 2008-10-14 CN CN200880113322A patent/CN101848933A/zh active Pending
- 2008-10-14 US US12/738,337 patent/US20100330697A1/en not_active Abandoned
- 2008-10-14 JP JP2010530308A patent/JP2011501757A/ja not_active Abandoned
- 2008-10-14 AU AU2008315951A patent/AU2008315951A1/en not_active Withdrawn
- 2008-10-14 WO PCT/EP2008/008670 patent/WO2009052971A1/en active Application Filing
- 2008-10-14 EP EP08843272A patent/EP2205628A1/en not_active Withdrawn
- 2008-10-14 MX MX2010004097A patent/MX2010004097A/es unknown
- 2008-10-14 CA CA2702508A patent/CA2702508A1/en not_active Withdrawn
- 2008-10-23 TW TW097140558A patent/TW200934789A/zh unknown
- 2008-10-23 AR ARP080104623A patent/AR069007A1/es unknown
-
2010
- 2010-04-21 IL IL205218A patent/IL205218A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20100330697A1 (en) | 2010-12-30 |
IL205218A0 (en) | 2010-11-30 |
EP2053059A1 (en) | 2009-04-29 |
WO2009052971A1 (en) | 2009-04-30 |
TW200934789A (en) | 2009-08-16 |
JP2011501757A (ja) | 2011-01-13 |
KR20100076992A (ko) | 2010-07-06 |
AU2008315951A1 (en) | 2009-04-30 |
EP2205628A1 (en) | 2010-07-14 |
CA2702508A1 (en) | 2009-04-30 |
MX2010004097A (es) | 2010-04-30 |
CN101848933A (zh) | 2010-09-29 |
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