AR063545A1 - Derivados de tiazoles -1,3 aminosustituidos, composiciones farmaceuticas que las contienen y usos como agentes anticancer - Google Patents
Derivados de tiazoles -1,3 aminosustituidos, composiciones farmaceuticas que las contienen y usos como agentes anticancerInfo
- Publication number
- AR063545A1 AR063545A1 ARP070104808A ARP070104808A AR063545A1 AR 063545 A1 AR063545 A1 AR 063545A1 AR P070104808 A ARP070104808 A AR P070104808A AR P070104808 A ARP070104808 A AR P070104808A AR 063545 A1 AR063545 A1 AR 063545A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkylene
- alkyl
- aryl
- heteroaryl
- heterocyclyl
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 36
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000001188 haloalkyl group Chemical group 0.000 abstract 10
- 125000003118 aryl group Chemical group 0.000 abstract 9
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 125000000623 heterocyclic group Chemical group 0.000 abstract 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 8
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 7
- 229910052799 carbon Inorganic materials 0.000 abstract 6
- 150000001721 carbon Chemical group 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 4
- 125000000732 arylene group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000005549 heteroarylene group Chemical group 0.000 abstract 3
- -1 -OH Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Reivindicacion 1: Un compuesto que tiene la formula (1) o una sal, solvato, éster, profármaco o estereoisomero farmacéuticamente aceptable del mismo, donde la línea entre cortada indica un enlace opcional y adicional y donde: R1 es H, alquilo, alquenilo, alquinilo, -(alquileno)m-arilo, -(alquileno)m-cicloalquilo, -(alquileno)m-heteroarilo, -(alquileno)m-heterociclilo o -(alquileno)m-heterocilenilo, donde cualquier grupo arilo, cicloalquilo, heteroarilo, heterociclilo o heterociclenilo puede estar opcional e independientemente sustituido en un átomo de carbono anular o de nitrogeno anular con hasta 3 sustituyentes seleccionados entre halo, alquilo, -O-alquilo, -(alquenileno)m-NR(9)2, -C(O)OR7, -CN, -OH, -(alquileno)m-heteroarilo y -(alquileno)m-arilo; y donde cualquier grupo sustituyente arilo o heteroarilo puede estar sustituido con hasta 5 sustituyentes, que pueden ser iguales o diferentes, y se seleccionan entre -halo, -OH, alquilo, -C(O)OH, -C(O)O-alquilo, -N(R9)2, y -O- alquilo; y donde cualquier grupo arilo, cicloalquilo, heteroarilo, heterociclilo o heterociclenilo puede estar opcionalmente fusionado a un grupo arilo, cicloalquilo, heteroarilo, heterociclilo o heterociclenilo; R2 es H, alquilo, arilo, heteroarilo, -C(O)-alquilo o -C(O)-arilo, donde el arilo, heteroarilo o porcion arilo o un grupo -C(O)-arilo puede estar sustituido con hasta 3 sustituyentes, que pueden ser iguales o diferentes, y se seleccionan independientemente entre halo, alquilo, -C(O)OH, y -O-alquilo; cada caso de R3 es independientemente H, alquilo, haloalquilo, hidroxialquilo, -(alquileno)m-C(O)N(R8)2, -(alquileno)m-NHC(O)-R9 o -(alquileno)m-N(R9)2, o R3 y el átomo de carbono anular al cual esta unido se combinan para formar un grupo carbonilo; R4 es H, -alquilo, haloalquilo, hidroxialquilo, -(alquileno)m-C(O)N(R8)2, -(alquileno)m-NHC(O)-R9 o -(alquileno)m-N(R9)2, o R3 y R3a, junto con el átomo de carbono comun al cual cada uno esta unido, se une para formar un grupo carbonilo, cicloalquilo o heterociclilo; R4a es H, -alquilo, haloalquilo, hidroxialquilo, -(alquileno)m-C(O)N(R8)2, -(alquileno)m-NHC(O)-R9 o -(alquileno)m-N(R9)2; cada caso de R5 es independientemente H, -alquilo, -(alquileno)m-arilo, - (alquileno)m-heteroarilo, -(alquileno)m-heterociclilo, -(alquileno)m-N(R9)2, -(alquileno)m-OH, -(alquileno)m-NHC(O)R9, hidroxialquilo, haloalquilo, -C(O)R6, -C(O)OR9, -C(O)-(alquileno)m-N(R9)2, -(alquileno)m-NHC(O)R7, -NHC(O)OR9 o -NHS(O)2R7; R6 es H, alquilo, arilo, heteroarilo o -NHOH; R7 es H, alquilo o haloalquilo; R8 es H, -OH, alquilo, -O-alquilo, o haloalquilo; R9 es H, alquilo, arilo, heterociclilo, heteroarilo o cicloalquilo; R10 es H, -alquilo, haloalquilo, hidroxialquilo, - (alquileno)m-C(O)N(R8)2, -(alquileno)m-NHC(O)R9 o -(alquileno)m-N(R9)2, o R10 y R10a, junto con el átomo de carbono comun al cual cada uno esta unido, se unen para formar un grupo carbonilo, cicloalquilo o heterociclilo; R10a es H, alquilo, haloalquilo, hidroxialquilo, -(alquileno)m-C(O)N(R8)2, -(alquileno)m-NHC(O)-R9 o -(alquileno)m-N(R9)2; cada caso de R11 es independientemente H, alquilo, haloalquilo, hidroxialquilo, -(alquileno)m-C(O)N(R8)2, -(alquileno)m-NHC(O)-R9 o -(alquileno)m- N(R9)2, o R11 y el átomo de carbono anular al cual esta unido se combinan para formar un grupo carbonilo; cada caso de R12 es independientemente H, -(alquileno)m-arilo, -(alquileno)m-heteroarilo, -(alquileno)m-heterociclilo, -S(O)2-alquilo, -S(O)2- arilo, -S(O)2-heteroarilo, hidroxialquilo, -C(O)R9 o -C(O)OR9; Ar es arileno o heteroarileno, donde el arileno o heteroarileno se une mediante 2 cualquiera de sus átomos de carbono anulares adyacentes, y donde el grupo arileno o heteroarileno puede estar opcionalmente sustituido con hasta 4 sustituyentes, que pueden ser iguales o diferentes, y se seleccionan independientemente entre halo, alquilo, alcoxi, ariloxi, -NH2, -NH-alquilo, -N(alquilo)2, -SR8, -S(O)R8, -C(O)R8, -C(O)OR8, -C(O)N(R8)2, - NHC(O)R8, haloalquilo, -CN y NO2, de modo que cuando Ar es tetrahidronaftileno, R3 y r4 son cada uno distinto de hidrogeno; W es -N(R12)2-, -S-, -O- o -C(R5)2-, donde ambos grupos R5 y el átomo de carbono comun al cual están unidos se pueden combinar para formar un grupo cicloalquilo o heterociclilo, cada uno de los cuales puede estar sustituido adicionalmente; Y es H, halo, alquilo o -CN; Z es -C(R8)- o -N-, de modo que cuando está presenta el enlace opcional adicional, Z es -C(R8)-; cada caso de m es independientemente 0 o 1; n es un numero entero que va de 0 a 2; y p es 0 o 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85542006P | 2006-10-31 | 2006-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063545A1 true AR063545A1 (es) | 2009-01-28 |
Family
ID=39247333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070104808A AR063545A1 (es) | 2006-10-31 | 2007-10-30 | Derivados de tiazoles -1,3 aminosustituidos, composiciones farmaceuticas que las contienen y usos como agentes anticancer |
Country Status (12)
Country | Link |
---|---|
US (1) | US8227605B2 (es) |
EP (1) | EP2078002B1 (es) |
JP (1) | JP5103604B2 (es) |
KR (1) | KR20090075869A (es) |
CN (1) | CN101573345A (es) |
AR (1) | AR063545A1 (es) |
AU (1) | AU2007314341B2 (es) |
CA (1) | CA2668209A1 (es) |
IL (1) | IL198398A0 (es) |
MX (1) | MX2009004785A (es) |
TW (1) | TW200829582A (es) |
WO (1) | WO2008054701A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8163746B2 (en) | 2006-04-19 | 2012-04-24 | Astellas Pharma Inc. | Azolecarboxamide derivative |
AU2008314922B2 (en) | 2007-10-24 | 2013-08-29 | Astellas Pharma Inc. | Azolecarboxamide compound or salt thereof |
WO2009058729A2 (en) * | 2007-10-29 | 2009-05-07 | Schering Corporation | Thiazole carboxamide derivatives and their to treat cancer |
CA2703980A1 (en) * | 2007-10-29 | 2009-05-07 | Schering Corporation | Diamido thiazole derivatives as protein kinase inhibitors |
CA2703981A1 (en) * | 2007-10-29 | 2009-05-07 | Schering Corporation | Heterocyclic urea and thiourea derivatives and methods of use thereof |
JP5230035B2 (ja) * | 2007-10-29 | 2013-07-10 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼ阻害剤としてのチアゾール誘導体 |
UY31679A1 (es) * | 2008-03-03 | 2009-09-30 | Inhibidores de cinasa pim y metodos para su uso | |
US8168794B2 (en) | 2008-03-03 | 2012-05-01 | Novartis Ag | Pim kinase inhibitors and methods of their use |
BR122021005861B1 (pt) | 2008-12-03 | 2023-10-24 | The Scripps Research Institute | Composto, métodos para estabilizar uma célula animal isolada in vitro e para manter a sobrevivência da célula, e, composição |
EP2470183B1 (en) | 2009-08-26 | 2015-09-16 | Merck Sharp & Dohme Corp. | Heterocyclic amide compounds as protein kinase inhibitors |
US8435976B2 (en) * | 2009-09-08 | 2013-05-07 | F. Hoffmann-La Roche | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
WO2012004217A1 (en) * | 2010-07-06 | 2012-01-12 | Novartis Ag | Cyclic ether compounds useful as kinase inhibitors |
FR2973597B1 (fr) | 2011-04-04 | 2018-05-25 | Somfy Sas | Partie de boitier electrique ou electronique et procede de fixation d'une telle partie de boitier sur une structure |
CN103204824B (zh) * | 2012-01-12 | 2015-04-08 | 清华大学深圳研究生院 | 2-氨基噻唑-4-酰胺类衍生物及其制备方法与应用 |
CN102617582A (zh) * | 2012-02-21 | 2012-08-01 | 南开大学 | 三氮唑埃博霉素类似物,其药物组合物及其制备方法和用途 |
KR20150013548A (ko) | 2012-05-21 | 2015-02-05 | 노파르티스 아게 | 키나제 억제제로서의 신규 고리-치환된 n-피리디닐 아미드 |
KR102427777B1 (ko) | 2012-06-26 | 2022-08-01 | 델 마 파마슈티컬스 | 디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, ahi1 조절곤란 또는 돌연변이를 치료하는 방법 |
WO2014118186A1 (en) * | 2013-01-30 | 2014-08-07 | Bayer Pharma Aktiengesellschaft | Amino-substituted isothiazoles |
US11491154B2 (en) | 2013-04-08 | 2022-11-08 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
US9993460B2 (en) | 2013-07-26 | 2018-06-12 | Race Oncology Ltd. | Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof |
US10221172B2 (en) | 2015-01-13 | 2019-03-05 | Vanderbilt University | Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
WO2019002074A1 (en) * | 2017-06-29 | 2019-01-03 | Bayer Aktiengesellschaft | THIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PRMT5 |
WO2019195959A1 (en) | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
AU2020363100A1 (en) * | 2019-10-09 | 2022-05-12 | Cothera Bioscience, Inc. | Combination therapy for cancers with KRAS mutation |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE355841T1 (de) | 1997-12-13 | 2007-03-15 | Bristol Myers Squibb Co | Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer |
US6413974B1 (en) | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
JP3989175B2 (ja) | 1999-04-15 | 2007-10-10 | ブリストル−マイヤーズ スクイブ カンパニー | 環状タンパク質チロシンキナーゼ阻害剤 |
NZ525016A (en) | 2000-09-15 | 2004-10-29 | Vertex Pharma | Isoxazoles and their use as inhibitors of ERK |
US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7105682B2 (en) * | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
EP1781647A2 (en) * | 2004-07-22 | 2007-05-09 | Astex Therapeutics Limited | Thiazole and isothiazole derivatives as protein kinase inhibitors |
EP1637529A1 (en) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
US8163746B2 (en) * | 2006-04-19 | 2012-04-24 | Astellas Pharma Inc. | Azolecarboxamide derivative |
AU2007314305B2 (en) * | 2006-10-31 | 2013-01-24 | Merck Sharp & Dohme Corp. | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors |
CA2694218A1 (en) * | 2007-07-31 | 2009-02-05 | Schering Corporation | Anti-mitotic agent and aurora kinase inhibitor combination as anti-cancer treatment |
CA2703981A1 (en) * | 2007-10-29 | 2009-05-07 | Schering Corporation | Heterocyclic urea and thiourea derivatives and methods of use thereof |
JP5230035B2 (ja) * | 2007-10-29 | 2013-07-10 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼ阻害剤としてのチアゾール誘導体 |
JP2012509275A (ja) * | 2008-11-19 | 2012-04-19 | シェーリング コーポレイション | ジアシルグリセロールアシルトランスフェラーゼの阻害薬 |
-
2007
- 2007-10-29 US US12/447,709 patent/US8227605B2/en active Active
- 2007-10-29 KR KR1020097010778A patent/KR20090075869A/ko not_active Application Discontinuation
- 2007-10-29 CN CNA2007800490742A patent/CN101573345A/zh active Pending
- 2007-10-29 AU AU2007314341A patent/AU2007314341B2/en not_active Ceased
- 2007-10-29 CA CA002668209A patent/CA2668209A1/en not_active Abandoned
- 2007-10-29 WO PCT/US2007/022827 patent/WO2008054701A1/en active Application Filing
- 2007-10-29 MX MX2009004785A patent/MX2009004785A/es unknown
- 2007-10-29 JP JP2009534690A patent/JP5103604B2/ja not_active Expired - Fee Related
- 2007-10-29 EP EP07853011.0A patent/EP2078002B1/en active Active
- 2007-10-30 AR ARP070104808A patent/AR063545A1/es not_active Application Discontinuation
- 2007-10-30 TW TW096140868A patent/TW200829582A/zh unknown
-
2009
- 2009-04-26 IL IL198398A patent/IL198398A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL198398A0 (en) | 2010-02-17 |
WO2008054701A1 (en) | 2008-05-08 |
CN101573345A (zh) | 2009-11-04 |
TW200829582A (en) | 2008-07-16 |
CA2668209A1 (en) | 2008-05-08 |
EP2078002A1 (en) | 2009-07-15 |
JP2010508273A (ja) | 2010-03-18 |
KR20090075869A (ko) | 2009-07-09 |
EP2078002B1 (en) | 2013-08-28 |
MX2009004785A (es) | 2009-06-05 |
US20100055090A1 (en) | 2010-03-04 |
AU2007314341A1 (en) | 2008-05-08 |
US8227605B2 (en) | 2012-07-24 |
AU2007314341B2 (en) | 2013-04-11 |
JP5103604B2 (ja) | 2012-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR063545A1 (es) | Derivados de tiazoles -1,3 aminosustituidos, composiciones farmaceuticas que las contienen y usos como agentes anticancer | |
AR063531A1 (es) | Derivados de anilinopiperazina y composicion farmaceutica | |
AR063721A1 (es) | Derivados de anilinopiperazina y composicion farmaceutica | |
AR068106A1 (es) | Derivados de indol 2-carboxi sustituidos y una composicion farmaceutica | |
AR069083A1 (es) | Derivados heterociclicos de 1,3-tiazol inhibidores de proteinquinasas, composiciones farmaceuticas que los contienen y usos de los mismos en el tratamiento o prevencion de trastornos proliferativos. | |
AR064429A1 (es) | Derivados indolicos con anillo unidos en las posiciones 4,5, composiciones farmaceuticas que los contienen y usos de los mismos en la prevencion y/o tratamiento de infecciones virales. | |
AR068109A1 (es) | Derivados tetraciclicos de indol y una composicion farmaceutica | |
AR035371A1 (es) | Aminotiazoles, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de un medicamento | |
AR048537A1 (es) | Derivados de nucleosidos para tratar infecciones por virus de hepatitis c. | |
AR064428A1 (es) | Derivados indolicos con anillo unido en las posiciones 4,5 y sus metodos de uso. composiciones farmaceuticas | |
PE20170775A1 (es) | Derivados de benzodiazepina citotoxicos | |
AR065499A1 (es) | Inhibidores de serino proteasas.composiciones farmaceuticas | |
AR064430A1 (es) | Derivados indolicos con anillo unido en las posiciones 5,6 . composiciones farmaceuticas y uso de los mismos. | |
AR040336A1 (es) | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto | |
AR117264A1 (es) | Esteroides neuroactivos y métodos para su uso | |
AR077328A1 (es) | Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos | |
CO5580815A2 (es) | Derivados de adamantana, procesos para su preparacion y composiciones farmaceuticas que los contienen | |
AR067613A1 (es) | Inhibidores de adn-pk, uso y sintesis de los mismos | |
AR068107A1 (es) | Derivados indolicos 2,3 sustituidos y una composicion farmaceutica | |
BRPI0606367A2 (pt) | derivados espirocetais e composições farmacêuticas compreendendo os mesmos | |
AR081848A1 (es) | Inhibidores de la proteina ns5a del vhc | |
DOP2007000079A (es) | Compuestos fenil amido heterocíclicos condensados | |
AR056186A1 (es) | Compuesto de imidazo[1,2-a]piridinilo, su uso para la fabricacion de un medicamento y formulacion farmaceutica que lo comprende | |
GT200600164A (es) | Derivados de dihidrobenzofuranos y usos de los mismos | |
CR8755A (es) | Derivado de quinolina fusionada y uso del mismo |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |