AR062624A1 - Proceso quimico para preparar compuestos inhibidores de metaloproteinasas - Google Patents
Proceso quimico para preparar compuestos inhibidores de metaloproteinasasInfo
- Publication number
- AR062624A1 AR062624A1 ARP070103880A ARP070103880A AR062624A1 AR 062624 A1 AR062624 A1 AR 062624A1 AR P070103880 A ARP070103880 A AR P070103880A AR P070103880 A ARP070103880 A AR P070103880A AR 062624 A1 AR062624 A1 AR 062624A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- compound
- formula
- group
- salt
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000001311 chemical methods and process Methods 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000003287 optical effect Effects 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
El proceso es apropiado para preparar, por ejemplo, intermediarios para compuestos farmacéuticos. También se describen y reivindican determinados intermediarios novedosos. Reivindicacion 1: Un proceso para preparar un compuesto con actividad optica de formula (2), o una sal de éste, donde * indica un centro estereogénico; R1 es un grupo hidrocarbilo opcionalmente sustituido; R7 es un grupo hidrocarbilo opcionalmente sustituido, o un grupo heterocíclico opcionalmente sustituido, caracterizado porque comprende la hidrolisis ácida de un compuesto de formula (4) con actividad optica, donde R1 y R7 son como se los definio con anterioridad; y uno de R5 o R6 es un grupo aromático opcionalmente sustituido o un grupo sustractor de electrones, y el otro es un grupo alquilo opcionalmente sustituido, recuperar el compuesto de formula 2 con actividad optica como una sal, y después, si se lo desea, convertir la sal en un compuesto de formula 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0617367.8A GB0617367D0 (en) | 2006-09-02 | 2006-09-02 | Novel process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062624A1 true AR062624A1 (es) | 2008-11-19 |
Family
ID=37137284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103880A AR062624A1 (es) | 2006-09-02 | 2007-08-31 | Proceso quimico para preparar compuestos inhibidores de metaloproteinasas |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080071085A1 (es) |
| JP (1) | JP2010502580A (es) |
| CN (1) | CN101511814A (es) |
| AR (1) | AR062624A1 (es) |
| CL (1) | CL2007002549A1 (es) |
| GB (1) | GB0617367D0 (es) |
| TW (1) | TW200823194A (es) |
| WO (1) | WO2008029087A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0617366D0 (en) * | 2006-09-02 | 2006-10-11 | Astrazeneca Ab | Novel process |
| US20170251557A1 (en) * | 2016-02-29 | 2017-08-31 | Rohm And Haas Electronic Materials Llc | Horizontal method of electroless metal plating of substrates with ionic catalysts |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ515829A (en) * | 1999-06-04 | 2003-10-31 | Astrazeneca Ab | Inhibitors of metalloproteinases |
| JP4256095B2 (ja) * | 2000-02-21 | 2009-04-22 | アストラゼネカ・アクチエボラーグ | メタロプロテイナーゼの阻害剤としてのピペリジン−およびピペラジン置換ｎ−ヒドロキシホルムアミド類 |
| GB0617366D0 (en) * | 2006-09-02 | 2006-10-11 | Astrazeneca Ab | Novel process |
-
2006
- 2006-09-02 GB GBGB0617367.8A patent/GB0617367D0/en not_active Ceased
-
2007
- 2007-08-22 TW TW096131062A patent/TW200823194A/zh unknown
- 2007-08-30 CN CNA2007800325730A patent/CN101511814A/zh active Pending
- 2007-08-30 WO PCT/GB2007/003269 patent/WO2008029087A1/en active Application Filing
- 2007-08-30 JP JP2009526170A patent/JP2010502580A/ja active Pending
- 2007-08-31 CL CL200702549A patent/CL2007002549A1/es unknown
- 2007-08-31 AR ARP070103880A patent/AR062624A1/es unknown
- 2007-08-31 US US11/897,996 patent/US20080071085A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008029087A1 (en) | 2008-03-13 |
| JP2010502580A (ja) | 2010-01-28 |
| CL2007002549A1 (es) | 2008-04-04 |
| TW200823194A (en) | 2008-06-01 |
| CN101511814A (zh) | 2009-08-19 |
| US20080071085A1 (en) | 2008-03-20 |
| GB0617367D0 (en) | 2006-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |