AR062266A1 - Proceso mejorado para sintetizar base libre de desvenlafaxina y sus sales o solvatos - Google Patents

Proceso mejorado para sintetizar base libre de desvenlafaxina y sus sales o solvatos

Info

Publication number
AR062266A1
AR062266A1 ARP070103448A ARP070103448A AR062266A1 AR 062266 A1 AR062266 A1 AR 062266A1 AR P070103448 A ARP070103448 A AR P070103448A AR P070103448 A ARP070103448 A AR P070103448A AR 062266 A1 AR062266 A1 AR 062266A1
Authority
AR
Argentina
Prior art keywords
salts
solvates
devenlafaxine
synthetize
improved process
Prior art date
Application number
ARP070103448A
Other languages
English (en)
Inventor
Gutierrez Iolanda Chamorro
I Llado Jordi Bosch
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR062266A1 publication Critical patent/AR062266A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Reivindicacion 1: Un proceso para preparar base libre de desvenlafaxina y sus sales o solvatos caracterizado porque comprende N,N-dimetilar 4-[2-amino-1-(hidroxiciclohexil)etil]fenol (Compuesto III) para obtener base libre de desvenlafaxina.
ARP070103448A 2006-08-04 2007-08-03 Proceso mejorado para sintetizar base libre de desvenlafaxina y sus sales o solvatos AR062266A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83544806P 2006-08-04 2006-08-04
US90754107P 2007-04-06 2007-04-06

Publications (1)

Publication Number Publication Date
AR062266A1 true AR062266A1 (es) 2008-10-29

Family

ID=38997535

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103448A AR062266A1 (es) 2006-08-04 2007-08-03 Proceso mejorado para sintetizar base libre de desvenlafaxina y sus sales o solvatos

Country Status (5)

Country Link
US (1) US20100121108A1 (es)
EP (1) EP2061750A2 (es)
AR (1) AR062266A1 (es)
ES (1) ES2334765B1 (es)
WO (1) WO2008015584A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007016179A (es) 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
US20090069601A1 (en) * 2006-07-26 2009-03-12 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
CA2656161A1 (en) 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Process for the synthesis of o-desmethylvenlafaxine
KR101343027B1 (ko) 2007-11-26 2013-12-18 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
KR101409554B1 (ko) 2010-03-29 2014-06-19 플리바 흐르바츠카 디.오.오. Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
CZ303249B6 (cs) 2010-04-06 2012-06-20 Zentiva, K.S. Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
CN113402400B (zh) * 2021-04-29 2023-12-08 深圳市新浩瑞医药科技有限公司 一种去甲文拉法辛的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
GB8902209D0 (en) * 1989-02-01 1989-03-22 Wyeth John And Brother Limited Preparation of cyclohexanol derivatives and novel thioamide intermediates
US6197828B1 (en) * 1998-12-01 2001-03-06 Sepracor, Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
DE60039132D1 (de) * 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
PT1360169E (pt) * 2001-02-12 2007-10-29 Wyeth Corp Sal succinato de o-desmetil-venlafaxina
UA80543C2 (en) * 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine
TWI306092B (en) * 2003-03-11 2009-02-11 Wyeth Corp Process for preparation of phenethylamine derivatives
EP2007708A1 (en) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Substantially pure o-desmethylvenlafaxine and processes for preparing it
CA2656161A1 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Process for the synthesis of o-desmethylvenlafaxine

Also Published As

Publication number Publication date
US20100121108A1 (en) 2010-05-13
WO2008015584A3 (en) 2008-06-12
EP2061750A2 (en) 2009-05-27
ES2334765A1 (es) 2010-03-15
WO2008015584A2 (en) 2008-02-07
ES2334765B1 (es) 2010-12-20

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