AR062038A1 - Neurotrofinas modificadas post-traduccionalmente - Google Patents
Neurotrofinas modificadas post-traduccionalmenteInfo
- Publication number
- AR062038A1 AR062038A1 ARP070103275A ARP070103275A AR062038A1 AR 062038 A1 AR062038 A1 AR 062038A1 AR P070103275 A ARP070103275 A AR P070103275A AR P070103275 A ARP070103275 A AR P070103275A AR 062038 A1 AR062038 A1 AR 062038A1
- Authority
- AR
- Argentina
- Prior art keywords
- retained
- conserved
- trp
- residue selected
- post
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Las neurotrofinas sufren modificaciones post-transduccionales y estas modificaciones post-transduccionales median la actividad pro-apoptótica y/o pro-neuritas de las neurotrofinas. Estas modificaciones post-transduccionales incluyen notablemente la nitración y la formación de dímeros de diferente conformación, así como también de oligómeros anormales, tales como tetrámeros y octámeros. Se proveen así agentes útiles para el tratamiento de las condiciones o enfermedades que involucran dolor crónico y/o pérdidas neuronales. Reivindicación 1: Un inductor y/o estimulador de la apoptosis neuronal motriz y/o del crecimiento de neuritas, el cual comprende: una neurotrofina modificada en una forma aislada, en donde por lo menos un residuo seleccionado de residuos Tyr y Trp comprende por lo menos un grupo nitrito, un fragmento conservado de dicha forma aislada de la neurotrofina modificada, en donde dicho fragmento conservado tiene retenido por lo menos un residuo seleccionado entre residuos Tyr y Trp, y donde dicho fragmento conservado tiene retenido por lo menos un grupo nitro en dicho al menos un residuo seleccionado entre residuos Tyr y Trp, y tiene retenida una capacidad de inducir y/o estimular la apoptosis neuronal motriz y/o el crecimiento de neuritas; o una variante conservada de dicha forma aislada de la neurotrofina modificada o de dicho fragmento conservado, en donde dicha variante conservada deriva de dicha neurotrofina modificada o de dicho fragmento conservado por la substitución y/o deleción y/o agregado de al menos un aminoácido, pero tiene retenido por lo menos un residuo seleccionado entre residuos Tyr y Trp, y donde dicha variante conservada tiene retenido por lo menos un grupo nitro en dicho al menos un residuo seleccionado entre residuos Tyr y Trp, y tiene retenida una capacidad de inducir y/o estimular la apoptosis neuronal motriz y/o el crecimiento de neuritas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06291195A EP1882697B1 (en) | 2006-07-24 | 2006-07-24 | Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins |
Publications (1)
Publication Number | Publication Date |
---|---|
AR062038A1 true AR062038A1 (es) | 2008-08-10 |
Family
ID=37075006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070103275A AR062038A1 (es) | 2006-07-24 | 2007-07-24 | Neurotrofinas modificadas post-traduccionalmente |
Country Status (11)
Country | Link |
---|---|
US (2) | US20100055109A1 (es) |
EP (2) | EP1882697B1 (es) |
JP (1) | JP5528803B2 (es) |
AR (1) | AR062038A1 (es) |
AT (1) | ATE465179T1 (es) |
BR (1) | BRPI0714545A2 (es) |
CA (1) | CA2657563A1 (es) |
DE (1) | DE602006013809D1 (es) |
HK (1) | HK1116806A1 (es) |
UY (1) | UY30501A1 (es) |
WO (1) | WO2008012049A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1882697B1 (en) * | 2006-07-24 | 2010-04-21 | Institut Pasteur | Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins |
US20120135973A1 (en) * | 2010-09-08 | 2012-05-31 | Southern Illinois University Edwardsville | Method for treating chronic pain |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
WO2012075340A2 (en) | 2010-12-01 | 2012-06-07 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
GB201214007D0 (en) * | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
CN110869386A (zh) * | 2017-02-10 | 2020-03-06 | 维维巴巴公司 | 重组神经生长因子的组合物和方法 |
AU2019243155A1 (en) * | 2018-03-27 | 2020-10-15 | Factor Bioscience Inc. | Nucleic acid-based therapeutics |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
WO1996002576A1 (fr) | 1994-07-13 | 1996-02-01 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain reconstitue contre l'interleukine-8 humaine |
US6068040A (en) | 1998-07-24 | 2000-05-30 | Alpine Overhead Doors, Inc. | Slat edge retainer for overhead rolling doors |
EP1500399A1 (en) | 2003-07-24 | 2005-01-26 | Institut Pasteur | Active or passive immunization against proapoptotic neurotrophins for the treatment or prevention of neurodegenerative deseases |
EP1882697B1 (en) * | 2006-07-24 | 2010-04-21 | Institut Pasteur | Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins |
-
2006
- 2006-07-24 EP EP06291195A patent/EP1882697B1/en not_active Not-in-force
- 2006-07-24 DE DE602006013809T patent/DE602006013809D1/de active Active
- 2006-07-24 AT AT06291195T patent/ATE465179T1/de not_active IP Right Cessation
-
2007
- 2007-07-23 BR BRPI0714545-4A patent/BRPI0714545A2/pt not_active IP Right Cessation
- 2007-07-23 CA CA002657563A patent/CA2657563A1/en not_active Abandoned
- 2007-07-23 US US12/374,485 patent/US20100055109A1/en not_active Abandoned
- 2007-07-23 EP EP07786268A patent/EP2046823B1/en not_active Not-in-force
- 2007-07-23 WO PCT/EP2007/006528 patent/WO2008012049A1/en active Application Filing
- 2007-07-23 JP JP2009521157A patent/JP5528803B2/ja not_active Expired - Fee Related
- 2007-07-24 UY UY30501A patent/UY30501A1/es not_active Application Discontinuation
- 2007-07-24 AR ARP070103275A patent/AR062038A1/es unknown
-
2008
- 2008-07-08 HK HK08107507.3A patent/HK1116806A1/xx not_active IP Right Cessation
-
2013
- 2013-09-26 US US14/037,973 patent/US9328163B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE602006013809D1 (de) | 2010-06-02 |
JP5528803B2 (ja) | 2014-06-25 |
US9328163B2 (en) | 2016-05-03 |
WO2008012049A1 (en) | 2008-01-31 |
EP2046823B1 (en) | 2012-11-21 |
CA2657563A1 (en) | 2008-01-31 |
HK1116806A1 (en) | 2009-01-02 |
EP1882697A1 (en) | 2008-01-30 |
EP1882697B1 (en) | 2010-04-21 |
JP2010501475A (ja) | 2010-01-21 |
ATE465179T1 (de) | 2010-05-15 |
EP2046823A1 (en) | 2009-04-15 |
BRPI0714545A2 (pt) | 2013-05-14 |
UY30501A1 (es) | 2009-04-30 |
US20100055109A1 (en) | 2010-03-04 |
US20140178384A1 (en) | 2014-06-26 |
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Legal Events
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FB | Suspension of granting procedure |