AR059767A1 - Profarmacos de analogos de cc-1065 y sus conjugados, un procedimiento para su preparacion, una composicion farmaceutica que lo comprende y el uso de estos para la fabricacion de un medicamento para el tratamiento del cancer. - Google Patents
Profarmacos de analogos de cc-1065 y sus conjugados, un procedimiento para su preparacion, una composicion farmaceutica que lo comprende y el uso de estos para la fabricacion de un medicamento para el tratamiento del cancer.Info
- Publication number
- AR059767A1 AR059767A1 ARP070100932A ARP070100932A AR059767A1 AR 059767 A1 AR059767 A1 AR 059767A1 AR P070100932 A ARP070100932 A AR P070100932A AR P070100932 A ARP070100932 A AR P070100932A AR 059767 A1 AR059767 A1 AR 059767A1
- Authority
- AR
- Argentina
- Prior art keywords
- prodrug
- subunit
- group
- prodrugs
- conjugates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Profármacos de análogos del antibiotico CC-1065 antitumoral que tiene un grupo protector escindible que contiene un ácido sulfonico que contiene carbamato de fenilo, en los que el grupo protector confiere mayor solubilidad en agua respecto al profármaco, y en los que el profármaco también tiene un resto tal como un sulfuro o un disulfuro, que pueden conjugarse a un reactivo de union a células tal como un anticuerpo. El uso terapéutico de tales conjugados profármacos se describe también; tales profármacos de agentes citotoxicos tienen uso terapéutico porque pueden liberar profármacos citotoxicos a una poblacion celular específica para conversion enzimática a fármacos citotoxicos de una manera dirigida. Reivindicacion 2: Un profármaco de acuerdo con la reivindicacion 1, en donde el análogo de CC-1065 se selecciona del grupo consistente en análogos formados a partir de una primera subunidad de formula (1) covalentemente enlazada a una segunda subunidad de la formula (2), (3), (4), (5), (6), (7), (8), (9), (10) o (11) a través de un enlace amida desde el grupo amino secundario del resto pirrolico de la primera subunidad al carboxilo C-2 de la segunda subunidad, en las que Y representa un grupo eliminable seleccionado de un haluro (fluoruro, cloruro, bromuro o yoduro), metanosulfonato, para-toluenosulfonato, trifluorometanosulfonato, mononitro- o dinitrofenolato; en donde R, R', R1-R6 son cada uno independientemente hidrogeno, alquilo C1-3 lineal, metoxi, hidroxilo, amino primario, amino secundario, amino terciario, o amido o un enlazador que proporciona enlace del profármaco a un agente de union a células, con tal de que al menos uno de R, R', R1-R6 sea un enlazador y en donde R7 es dicho grupo protector de ácido sulfonico que contiene carbamato, o sus sales farmacéuticamente aceptables, hidratos, o sales hidratadas, o las estructuras cristalinas polimorficas de estos compuestos o sus isomeros opticos, racematos, diastereoisomeros o enantiomeros.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06290379A EP1832577A1 (en) | 2006-03-07 | 2006-03-07 | Improved prodrugs of CC-1065 analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059767A1 true AR059767A1 (es) | 2008-04-30 |
Family
ID=36679356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100932A AR059767A1 (es) | 2006-03-07 | 2007-03-06 | Profarmacos de analogos de cc-1065 y sus conjugados, un procedimiento para su preparacion, una composicion farmaceutica que lo comprende y el uso de estos para la fabricacion de un medicamento para el tratamiento del cancer. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8012978B2 (es) |
| EP (2) | EP1832577A1 (es) |
| JP (1) | JP2009529030A (es) |
| KR (1) | KR20080106919A (es) |
| AR (1) | AR059767A1 (es) |
| AU (1) | AU2007222123A1 (es) |
| BR (1) | BRPI0708654A2 (es) |
| CA (1) | CA2642870A1 (es) |
| DO (1) | DOP2007000041A (es) |
| EA (1) | EA200870327A1 (es) |
| IL (1) | IL193673A0 (es) |
| MA (1) | MA30322B1 (es) |
| MX (1) | MX2008011431A (es) |
| NO (1) | NO20083910L (es) |
| PE (1) | PE20080691A1 (es) |
| TW (1) | TW200813028A (es) |
| UY (1) | UY30190A1 (es) |
| WO (1) | WO2007102069A1 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1392359E (pt) | 2001-05-11 | 2010-01-27 | Ludwig Inst For Cancer Res Ltd | Proteínas de ligação específica e suas utilizações |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US6756397B2 (en) * | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
| USRE47123E1 (en) | 2006-07-18 | 2018-11-13 | Sanofi | EPHA2 receptor antagonist antibodies |
| EP2126127B1 (en) * | 2007-01-25 | 2016-09-28 | Dana-Farber Cancer Institute, Inc. | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
| AU2008227123B2 (en) * | 2007-03-15 | 2014-03-27 | Ludwig Institute For Cancer Research Ltd. | Treatment method using EGFR antibodies and src inhibitors and related formulations |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| CN101896503B (zh) | 2007-08-14 | 2018-05-22 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US20090155289A1 (en) * | 2007-11-01 | 2009-06-18 | Steve Roberts | Furin-cleavable peptide linkers for drug-ligand conjugates |
| EP2344478B1 (en) | 2008-11-03 | 2017-09-27 | Syntarga B.V. | Cc-1065 analogs and their conjugates |
| FR2947269B1 (fr) | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
| FR2949469A1 (fr) | 2009-08-25 | 2011-03-04 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application en therapeutique |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| AR078471A1 (es) | 2009-10-02 | 2011-11-09 | Sanofi Aventis | COMPUESTOS MAITANSINOIDES Y EL USO DE ESTOS PARA PREPARAR CONJUGADOS CON UN ANTICUERPO LOS CUALES SE UTILIZAN COMO AGENTES ANTICANCERIGENOS Y EL PROCEDIMIENTO DE PREPARACIoN DE ESTOS CONJUGADOS |
| TW201116297A (en) | 2009-10-02 | 2011-05-16 | Sanofi Aventis | Antibodies that specifically bind to the EphA2 receptor |
| NO3056203T3 (es) * | 2010-04-21 | 2018-05-12 | ||
| FR2963007B1 (fr) | 2010-07-26 | 2013-04-05 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application therapeutique |
| WO2013148631A1 (en) * | 2012-03-30 | 2013-10-03 | The Scripps Research Institute | Cyclic prodrugs of duocarmycin analogs |
| HUE048574T2 (hu) | 2012-07-12 | 2020-08-28 | Hangzhou Dac Biotech Co Ltd | Sejthez kötõdõ molekulák citotoxikus szerekkel képzett konjugátumai |
| US10131682B2 (en) | 2012-11-24 | 2018-11-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| ES2687225T3 (es) | 2014-01-10 | 2018-10-24 | Synthon Biopharmaceuticals B.V. | Método de purificación de conjugados anticuerpo-fármaco unidos a Cys |
| AU2015205509B2 (en) | 2014-01-10 | 2019-08-15 | Byondis B.V. | Duocarmycin ADCs showing improved in vivo antitumor activity |
| SG11201605597VA (en) | 2014-01-10 | 2016-08-30 | Synthon Biopharmaceuticals Bv | Duocarmycin adcs for use in treatment of endometrial cancer |
| CN114262344A (zh) | 2014-02-28 | 2022-04-01 | 杭州多禧生物科技有限公司 | 带电荷链接体及其在共轭反应上的应用 |
| CA2991973C (en) | 2015-07-12 | 2021-12-07 | Suzhou M-Conj Biotech Co., Ltd. | Bridge linkers for conjugation of a cell-binding molecule |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| TW201808336A (zh) | 2016-05-11 | 2018-03-16 | 賽諾菲公司 | 用抗ｍｕｃ１類美登素免疫綴合物抗體治療腫瘤的治療方案 |
| WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
| KR20220150408A (ko) | 2016-11-14 | 2022-11-10 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| WO2021191219A1 (en) * | 2020-03-23 | 2021-09-30 | Helmholtz-Zentrum für Infektionsforschung GmbH | N-phenyl-3-mercaptopropanamide derivatives as metallo-beta-lactamase inhibitors for the treatment of bacterial infections |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5278324A (en) * | 1990-08-28 | 1994-01-11 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
| CA2076465C (en) * | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
| US5646298A (en) * | 1995-06-07 | 1997-07-08 | Procoron, Inc. | Cyclopropylindole prodrugs |
| US6756397B2 (en) * | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
| US6534660B1 (en) * | 2002-04-05 | 2003-03-18 | Immunogen, Inc. | CC-1065 analog synthesis |
-
2006
- 2006-03-07 EP EP06290379A patent/EP1832577A1/en not_active Withdrawn
-
2007
- 2007-03-05 PE PE2007000236A patent/PE20080691A1/es not_active Application Discontinuation
- 2007-03-06 AR ARP070100932A patent/AR059767A1/es unknown
- 2007-03-06 JP JP2008557845A patent/JP2009529030A/ja not_active Withdrawn
- 2007-03-06 EA EA200870327A patent/EA200870327A1/ru unknown
- 2007-03-06 DO DO2007000041A patent/DOP2007000041A/es unknown
- 2007-03-06 UY UY30190A patent/UY30190A1/es not_active Application Discontinuation
- 2007-03-06 WO PCT/IB2007/000521 patent/WO2007102069A1/en active Application Filing
- 2007-03-06 KR KR1020087021749A patent/KR20080106919A/ko not_active Application Discontinuation
- 2007-03-06 MX MX2008011431A patent/MX2008011431A/es not_active Application Discontinuation
- 2007-03-06 CA CA002642870A patent/CA2642870A1/en not_active Abandoned
- 2007-03-06 AU AU2007222123A patent/AU2007222123A1/en not_active Abandoned
- 2007-03-06 EP EP07713102A patent/EP1993999A1/en not_active Withdrawn
- 2007-03-06 BR BRPI0708654-7A patent/BRPI0708654A2/pt not_active Application Discontinuation
- 2007-03-06 TW TW096107668A patent/TW200813028A/zh unknown
-
2008
- 2008-08-25 IL IL193673A patent/IL193673A0/en unknown
- 2008-09-04 US US12/204,082 patent/US8012978B2/en not_active Expired - Fee Related
- 2008-09-12 NO NO20083910A patent/NO20083910L/no not_active Application Discontinuation
- 2008-09-29 MA MA31261A patent/MA30322B1/fr unknown
-
2011
- 2011-07-15 US US13/184,255 patent/US20110280890A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007102069A1 (en) | 2007-09-13 |
| BRPI0708654A2 (pt) | 2011-06-07 |
| JP2009529030A (ja) | 2009-08-13 |
| EP1993999A1 (en) | 2008-11-26 |
| MX2008011431A (es) | 2008-09-22 |
| MA30322B1 (fr) | 2009-04-01 |
| DOP2007000041A (es) | 2007-10-31 |
| AU2007222123A1 (en) | 2007-09-13 |
| EA200870327A1 (ru) | 2009-02-27 |
| UY30190A1 (es) | 2008-10-31 |
| IL193673A0 (en) | 2009-05-04 |
| PE20080691A1 (es) | 2008-06-04 |
| NO20083910L (no) | 2008-12-01 |
| CA2642870A1 (en) | 2007-09-13 |
| US8012978B2 (en) | 2011-09-06 |
| US20110280890A1 (en) | 2011-11-17 |
| KR20080106919A (ko) | 2008-12-09 |
| EP1832577A1 (en) | 2007-09-12 |
| US20090028821A1 (en) | 2009-01-29 |
| TW200813028A (en) | 2008-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR059767A1 (es) | Profarmacos de analogos de cc-1065 y sus conjugados, un procedimiento para su preparacion, una composicion farmaceutica que lo comprende y el uso de estos para la fabricacion de un medicamento para el tratamiento del cancer. | |
| ES2609084T3 (es) | Derivados de fenoxi y feniltio sustituidos para tratar trastornos proliferativos | |
| CU20110216A7 (es) | Derivados aminobutíricos sustituidos como inhibidores de neprilisina | |
| CO6470847A2 (es) | Derivados amino-propiónicos sustituidos como inhibidores de neprilisina | |
| AR083849A1 (es) | Antagonistas de mdm2 de espiro-oxindol | |
| ECSP109905A (es) | Moduladores de receptor 7 tipo toll | |
| AR063165A1 (es) | Derivados de acido boronico como inhibidores de amidihidrolasa de acidos grasos. composiciones farmaceuticas. | |
| CR20120237A (es) | Derivados del ácido carbamoil-metil-amino-acético sustituido como inhibidores de nep novedosos | |
| TW200744587A (en) | Azaindole derivatives exhibiting PGD2 receptor antagonism | |
| AR041635A1 (es) | Compuestos de 4-piperazinilbencenosulfonilindoles, preparacion de los mismos y composiciones farmaceuticas que los contienen | |
| CO6362010A2 (es) | Moduladores de los receptores tipo toll | |
| ECSP088412A (es) | Derivados de pirazina como moduladores de canal de sodio en el tratamiento del dolor | |
| ECSP088731A (es) | Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparación y las composiciones farmacéuticas que las contienen | |
| UY29312A1 (es) | Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones | |
| AR047685A1 (es) | Derivados de hexaciclopenta[c]pirrol como activadores de sistemas histaminicos centrales, un procedimiento para su preparacion, composiciones farmaceuticas que los contienen y medicamentos para el tratamiento de neuropatologias asociadas al envejecimiento cerebral | |
| AR064253A1 (es) | Compuestos de biciclocarboxiamida sustituidos composiciones farmaceuticas y una combinacion que los incluye y su uso en fabaricacion de un medicamento para el tratamiento de enfermedades mediadas por la actividad del receptor vr1 | |
| AR063119A1 (es) | Derivados de piridinonas sustituidas, composiciones farmaceuticas que los contienen y usos como antagonistas en trastornos asociados a receptores del tipo i de la hormona de melanina(mch-1 o mchr-1) | |
| AR073845A1 (es) | Derivados de acido l-glutamico y l-glutamina marcados con [f-18] (i), su uso y procedimiento para su preparacion y composiciones farmaceuticas | |
| BRPI0310032B8 (pt) | derivados de benzoxazina, seus usos e seus processos de produção, e composição farmacêutica | |
| BR0314352A (pt) | Indóis 2,7-substituìdos e seu uso como moduladores de 5-ht6 | |
| AR074593A1 (es) | Benzotiazol amidas para la deteccion del peptido beta amiloide | |
| ES2621802T3 (es) | Sulfóxidos alfa, beta-insaturados para tratar trastornos proliferativos | |
| AR045517A1 (es) | Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables | |
| AR078415A1 (es) | Derivados de acido 2- mercaptociclopentanocarboxilico, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| PE20030345A1 (es) | 3,5-dihidroxi-2,2-dimetil-valeroamidas protegidas para la sintesis de epotilonas y derivados y un procedimiento para su preparacion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |