AR059743A1 - Formulaciones farmaceuticas de una forma cristalina de monohidrato de 2- (3- fluor-4- hidroxifenil )-7- vinil-1,3- benzoaxol-5-ol - Google Patents
Formulaciones farmaceuticas de una forma cristalina de monohidrato de 2- (3- fluor-4- hidroxifenil )-7- vinil-1,3- benzoaxol-5-olInfo
- Publication number
- AR059743A1 AR059743A1 ARP070100904A ARP070100904A AR059743A1 AR 059743 A1 AR059743 A1 AR 059743A1 AR P070100904 A ARP070100904 A AR P070100904A AR P070100904 A ARP070100904 A AR P070100904A AR 059743 A1 AR059743 A1 AR 059743A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical formulation
- weight
- component
- fluor
- hydroxyphenyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente está dirigida a formulaciones farmacéuticas de una forma cristalina de monohidrato de un modulador de un receptor estrogénico, y composiciones farmacéuticas y procedimientos para la preparacion de éstas. Reivindicacion 2: Una formulacion farmacéutica líquida o semi-solida que comprende: (a) un primer componente portador que comprende desde aproximadamente 10% hasta aproximadamente 99,99% en peso de dicha formulacion farmacéutica; (b) un segundo componente portador opcional que comprende hasta aproximadamente 70% en peso de dicha formulacion farmacéutica; (c) un componente emulsionante/solubilizante que comprende desde aproximadamente 0,01% hasta aproximadamente 30% en peso de dicha formulacion farmacéutica; (d) un componente anti-cristalizacion/solubilizacion opcional que comprende desde aproximadamente 0,01% hasta aproximadamente 30% en peso de dicha formulacion farmacéutica; y (e) un agente farmacologico activo que comprende desde aproximadamente 0,01% hasta aproximadamente 80% de dicha formulacion farmacéutica, donde dicho agente farmacologico activo comprende la forma cristalina de monohidrato de 2-(3-fluor-4-hidroxifenil)-7-vinil-1,3-benzoxazol-5-ol. Reivindicacion 40: Una formulacion farmacéutica que comprende: (a) un primer componente diluyente/rellenador que comprende desde aproximadamente 30% hasta aproximadamente 95% en peso de dicha formulacion; (b) un segundo componente diluyente/rellenador opcional que comprende hasta aproximadamente 40% en peso de dicha formulacion farmacéutica; (c) un componente desintegrante que comprende desde aproximadamente 0,01% hasta aproximadamente 30% en peso de dicha formulacion farmacéutica; (d) un componente aglutinante que comprende desde aproximadamente 0,01% hasta aproximadamente 20% en peso de dicha formulacion farmacéutica; (e) un componente agente humectante que comprende desde aproximadamente 0,01% hasta aproximadamente 20% en peso de dicha formulacion farmacéutica; (f) un componente lubricante opcional que comprende desde aproximadamente 0,01% hasta aproximadamente 10% en peso de dicha formulacion farmacéutica; y (g) un agente farmacologico activo que comprende desde aproximadamente 0,01% hasta aproximadamente 80% en peso de dicha formulacion farmacéutica, donde dicho agente farmacologico activo comprende la forma cristalina de monohidrato de 2-(3-fluor-4-hidroxifenil)-7-vinil-1,3-benzoxazol-5-ol.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77989206P | 2006-03-06 | 2006-03-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR059743A1 true AR059743A1 (es) | 2008-04-23 |
Family
ID=38475772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070100904A AR059743A1 (es) | 2006-03-06 | 2007-03-05 | Formulaciones farmaceuticas de una forma cristalina de monohidrato de 2- (3- fluor-4- hidroxifenil )-7- vinil-1,3- benzoaxol-5-ol |
Country Status (6)
Country | Link |
---|---|
US (1) | US20070207202A1 (es) |
AR (1) | AR059743A1 (es) |
PA (1) | PA8717801A1 (es) |
PE (1) | PE20080116A1 (es) |
TW (1) | TW200800178A (es) |
WO (1) | WO2007103877A2 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080146630A1 (en) * | 2006-11-21 | 2008-06-19 | Wyeth | Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080175901A1 (en) * | 2006-11-21 | 2008-07-24 | Wyeth | Pharmaceutical formulations of a crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080176914A1 (en) * | 2006-11-21 | 2008-07-24 | Wyeth | Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080241234A1 (en) * | 2006-11-21 | 2008-10-02 | Wyeth | Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080139633A1 (en) * | 2006-11-21 | 2008-06-12 | Wyeth | Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080175900A1 (en) * | 2006-11-21 | 2008-07-24 | Wyeth | Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080132554A1 (en) * | 2006-11-21 | 2008-06-05 | Wyeth | Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20090239920A1 (en) * | 2006-11-21 | 2009-09-24 | Wyeth | Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3437599C2 (de) * | 1984-10-13 | 1987-04-16 | Dolorgiet GmbH & Co KG, 5205 St Augustin | Ibuprofen enthaltende Weichgelatinekapseln |
US5468502A (en) * | 1994-12-20 | 1995-11-21 | American Home Products Corporation | Ibuprofen enhancing solvent system |
UA83620C2 (ru) * | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
US20060121111A1 (en) * | 2004-12-02 | 2006-06-08 | Wyeth | Formulations of substituted benzoxazoles |
GT200500349A (es) * | 2004-12-02 | 2006-07-03 | Formulaciones de benzoxazoles substituidos | |
AU2005312031A1 (en) * | 2004-12-02 | 2006-06-08 | Wyeth | Formulations of substituted benzoxazoles |
CA2600339A1 (en) * | 2005-03-08 | 2006-09-14 | Wyeth | Crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol and their use as estrogen receptor modulators |
EP1984028A2 (en) * | 2006-02-14 | 2008-10-29 | Wyeth a Corporation of the State of Delaware | Aqueous pharmaceutical formulations of er selective ligands |
-
2007
- 2007-03-05 WO PCT/US2007/063319 patent/WO2007103877A2/en active Application Filing
- 2007-03-05 TW TW096107504A patent/TW200800178A/zh unknown
- 2007-03-05 AR ARP070100904A patent/AR059743A1/es not_active Application Discontinuation
- 2007-03-05 US US11/682,147 patent/US20070207202A1/en not_active Abandoned
- 2007-03-05 PE PE2007000231A patent/PE20080116A1/es not_active Application Discontinuation
- 2007-03-06 PA PA20078717801A patent/PA8717801A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2007103877A3 (en) | 2007-11-22 |
PA8717801A1 (es) | 2009-04-23 |
PE20080116A1 (es) | 2008-02-25 |
TW200800178A (en) | 2008-01-01 |
US20070207202A1 (en) | 2007-09-06 |
WO2007103877A2 (en) | 2007-09-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR059743A1 (es) | Formulaciones farmaceuticas de una forma cristalina de monohidrato de 2- (3- fluor-4- hidroxifenil )-7- vinil-1,3- benzoaxol-5-ol | |
DOP2007000024A (es) | Composiciones herbicidas concentradas y estables | |
PE20080117A1 (es) | Formulaciones farmaceuticas de una forma cristalina anhidra de 2-(3-fluor-4-hidroxifenil)-7-vinil-1,3-benzoxazol-5-ol | |
AR069301A1 (es) | Modificadores de asfalto para aplicaciones de mezcla tibia que incluyen promotor de la adhesion | |
GT201000095A (es) | Producto de dispersión sólida que contiene un compuesto a base de n-aril urea | |
CU20060153A7 (es) | Nueva forma cristalina v de agomelatina, procedimiento para su preparación y composiciones farmacéuticas que las contienen | |
ECSP056095A (es) | Métodos y composiciones farmacéuticas para la obtención confiable de niveles aceptables de testosterona en suero | |
WO2010041141A3 (en) | Oil-based foamable carriers and formulations | |
AR059741A1 (es) | Formulaciones farmaceuticas liquidas y semisolidas y procedimientos | |
EA200971081A1 (ru) | Пуриновые производные и их применение в качестве модуляторов толл-подобного рецептора 7 | |
CL2012000824A1 (es) | Anticuerpo que se une especificamente al epitopo que se une especificamente a un receptor epha2; conjugado de dicho anticuerpo que comprende un agente citotoxico derivado de un compuesto maitansinoide; metodo para preparar dicho conjugado; composicion farmaceutica. | |
PT2038290E (pt) | Moduladores de receptor do tipo toll 7 | |
CL2007001869A1 (es) | Compuestos derivados de bencimidazol; procedimiento de preparacion; composiciones farmaceuticas; y uso para el tratamiento y/o profilaxis de enfermedades que se modulan con agonistas del fxr, tal como dislipidemias, diabetes, cancer, osteoporosis y e | |
ECSP088623A (es) | Derivados de azepinoindol como agentes farmacéuticos | |
MX2009003735A (es) | Composicion en deposito inyectable y su procedimiento de preparacion. | |
ECSP088239A (es) | Composición de liberación de fármaco sostenida | |
MX355683B (es) | Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso. | |
UY30462A1 (es) | Composicion farmacéuticas que contiene un acido tetrahidrofolico. | |
CU20120080A7 (es) | Formulaciones de anticuerpo | |
PE20070188A1 (es) | Formulaciones de estrogenos conjugados y bazedoxifeno | |
BRPI0821616B8 (pt) | composição micelar de copolímero de bloco anfifílico contendo taxano e método para preparação da mesma | |
AR081036A1 (es) | Formulaciones farmaceuticas para tratar enfermedades relacionadas con el transportador de glucosa dependiente de sodio | |
AR084978A1 (es) | Metodo y composicion para suministrar ingrediente activo al aire y su uso | |
GT200500358A (es) | Compuestos organicos | |
CL2008001775A1 (es) | Compuestos derivados de 2-amino-7-alquinil-[1,8]naftiridona, inhibidores de vegfr-3; composición farmacéutica; combinación farmacéutica; procedimiento de preparación; compuesto intermediario; y uso en el tratamiento del cáncer. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |