AR056818A1 - Compuestos de indanil- y tetrahidronaftil-amino-tiourea para combatir pestes animales - Google Patents

Compuestos de indanil- y tetrahidronaftil-amino-tiourea para combatir pestes animales

Info

Publication number
AR056818A1
AR056818A1 ARP060105202A ARP060105202A AR056818A1 AR 056818 A1 AR056818 A1 AR 056818A1 AR P060105202 A ARP060105202 A AR P060105202A AR P060105202 A ARP060105202 A AR P060105202A AR 056818 A1 AR056818 A1 AR 056818A1
Authority
AR
Argentina
Prior art keywords
alkyl
amino
alkoxy
alkynyl
alkylthio
Prior art date
Application number
ARP060105202A
Other languages
English (en)
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of AR056818A1 publication Critical patent/AR056818A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/14—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/32—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing >N—CO—N< or >N—CS—N< groups directly attached to a cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

REIVINDICACIoN 1.- Un compuesto de indanil- y tetrahidronaftil-amino-tiourea caracterizado porque la formula (I) donde n es 1 o 2; m es 1, 2, 3 o 4, siendo preciso, que cuando m es más alto que 1, los radicales R1 pueden tener los mismo o diferentes significados, R1 es seleccionado entre: hidrogeno, halogeno, OH, SH, NH2, SO3H, COOH, ciano, azido, nitro, formilo, CONH2, CSNH2, CH=N-OH, CH=N-O-(C1-C6)-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C3-C8-cicloalquilo, C1-C6-alcoxi, C1-C6-alquilamino, di(C1-C6-alquil)amino, C1-C8-alquiltio, C2-C6-alquenilo, C2-C6-alqueniloxi, C2-C6-alquenilamino, C2-C6-alqueniltio, C2-C6-alquinilo, C2-C6-alquiniloxi, C2-C6-alquinilamino, C2-C6-alquiniltio, C1-C6-alquilsulfonilo, C1-C6-alquilsulfoxilo, C2-C6- alquenilsulfonilo, C2-C6-alquinilsulfonilo, (C1-C6-alcoxi)carbonilo, (C2-C6-alqueniloxi)carbonilo, (C2-C6-alquiniloxi)-carbonilo, (C1-C6-alquil)carboniloxi, C2-C6-alquenil-)carbonil-oxi o (C2-C6-alquinil)carboniloxi, (C2-C6-alquenil)carbonil-amino, pudiendo los átomos de carbono en los radicales alifáticos de los grupos antedichos llevar cualquier combinacion de 1, 2 o 3 radicales, seleccionados cada vez independientemente del grupo, que consiste de; halogeno, ciano, nitro, hidroxi, mercapto, amino, carboxilo, C1-C6-alquilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-haloalcoxi y C1-C6-alquiltio; C(O)NR1aR1b, (SO2)NR1aR1b, donde R1a y R1b significan cada vez independientemente, hidrogeno, OH, NH2, C1-C6-alquilo, C1-C6- haloalquilo, C2-C6-alquenilo o C2-C6-alquinilo; R1c es seleccionado entre: hidrogeno, C1-C6-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C3-C8-cicloalquilo, C1-C6-alcoxi, (C1-C6-alquil)amino, di(C1-C6-alquil)amino, hidracino, (C1-C6-alquil)hidracino, di(C1-C6-alquil)hidracino, fenilo y heteroarilo, que puede ser un anillo heteroaromático mono o bicíclico con 5 a 10 miembros, que contiene 1, 2, 3 o 4 heteroátomos seleccionados entre O, S y N; un radical Y-Ar o un radical Y-Cy, donde Y es un enlace simple, oxígeno, azufre, nitrogeno, C1-C6-alcandiilo o C1-C6-alcanodiiloxi; Ar es fenilo, naftilo o un anillo heteroaromático mono o bicíclico de 5 a 10 miembros, que contiene 1, 2, 3 o 4 heteroátomos seleccionados entre dos átomos de oxígeno, dos átomos de azufre y tres átomos de nitrogeno como miembros de anillo, donde Ar no lleva sustituyente o puede llevar cualquier combinacion de 1 a 5 radicales, seleccionados cada vez independientemente del grupo, que consiste de halogeno, ciano, nitro, hidroxi, mercapto, amino, carboxilo, C1-C6alquilo, C1-C6-haloalquilo, C1-6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-haloalcoxi y C1-C6-alquiltio; Cy es C3-C12-cicloalquilo, que no lleva sustituyente o está sustituido con 1 a 5 radicales, seleccionados cada vez independientemente del grupo que consiste de: halogeno, ciano, nitro, hidroxi, mercapto, amino, cargoxilo, C1-C6-haloalquilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-haloalcoxi y C1-C6-alquiltio; y donde el radical R1, que es ligado con átomos de carbono vecinos de los anillos fenilo, puede formar, junto con dichos átomos de carbono, un anillo benceno, condensado, un carbociclo saturado o parcialmente insaturado, condensado, de 5, 6 o 7 miembros o un heterociclo condensado, de 5, 6 o 7 miembros, que contiene 1, 2, 3 o 4 hereroátomos seleccionados entre dos átos de oxígeno, dos átomos de azugre y tres átmos de nitrogeno como miembros de anillo, y donde el anillo condensado no lleva sustituyente o puede llevar 1, 2, 3 o 4 radicales, seleccionados cada vez independientemente del grupo, que consiste de: halogeno, ciano, nitro, hidroxi, mercapto, amino, carboxilo, C1-C6-alquilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-haloalcoxi y C1-C6-alquiltio; R2 es seleccionado entre: hidrogeno, C(=O)R2d, C(=S)R2d, C1-C6-alquilo, C1-C6-alquilamino, di(C1-C6-alquil)amino, C2-C6-alquenilo, C2-C6-alquenilamino, C2-C6-Alquinilo, C2-C6-alquinilamino, di(C2-C6- alquinil)amino, C1-C6-alquilsulfonilo, C2-C6-alquenilsulfonilo, C2-C6-alquinilsulfonil C1-C6-alquilsulfinilo, C2-C6-alquenilsulfinilo, C2-C6-alquinilsulfinilo, C3-C12-cicloalquilo, P(=O)R2aR2b, P(=S)R2aR2b, NR2aR2b, SiR2aR2bR2c, N=CR2aR2b, CR2a=NR2b; fenilo o un sistema de anillo mono o bicíclico de 5 a 10 miembros, que pueden contener 1a 4 heteroátomos seleccionados entre oxígeno, azufre y nitrogeno y que no llevan sustituyente o están sustituidos con cualquier combinacion de 1 a 5 grupos seleccionados entre halogeno, ciano, nitro, hidroxi, mercapto, amino, carboxilo, C1-C6-alquilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-haloalcoxi, o C1-C6-alquiltio; y donde R2a, R2b y R2c son seleccionados cada vez independientemente entre hidrogeno, C1-C6-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-alquiltio, y pudiendo los átomos de carbono en estos grupos estar sustituidos por 1 a 3 sustituyentes seleccionados entre halogeno, ciano, nitro, hidroxi, mercapto, amino, carboxilo, C1-C6-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-haloalcoxi, o C1-C6-alquiltio; R2d es seleccionado entre: hidrogeno, C1-C6-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C1-C6-alquilamino, di(C1-C6-alquil)amino, C2-C6-alquinilamino, di(C2-C6-alquinil)amino, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-alquiltio, y pudiendo los átomos de carbono en estos grupos estar sustituidos por 1 a 3 sustituyentes seleccionados entre halogeno, ciano, nitro, hidroxi, mercapto, amino, carboxilo, C1-C6-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6- haloalcoxi, o C1-C6-alquiltio; fenilo o un sistema de anillo mono o bicíclico de 5 a 10 miembros, que puede contener 1 a 4 heteroátomos seleccionados entre oxígeno, azufre y nitrogeno y que no llevan sustituyente o están sustituidos con cualquier combinacion de 1 a 5 grupos seleccionados entre halogeno, ciano, nitro, hidroxi, mercapto, amino, carboxilo, C1-C6-alquilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-haloalcoxi, o C1-C6-alquiltio; R3, R4 son seleccionados entre hidrogeno, ciano, nitro, formilo, C(=O)R3c o C(=O)R4c, C1-C6-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C3-C8-cicloalquilo, C1-C6-alcoxi, (C1-C6-alcoxi)metileno, C1-C6-alquilsulfinilo, C1-C6-alquilsulfenilo o C1-C6- alquilsulfonilo, pudiendo los átomos de carbono en los radicales alifáticos de los grupos antedichos llevar cualquier combinacion de 1, 2 o 3 radicales, seleccionados cada vez independientemente del grupo, que consiste de: halogeno, ciano, nitro, hidroxi, mercapto, amino, carboxilo, C1-C6-alquilo, C1-C6-alcoxi, C2-C6-alqueniloxi, C2-C6-alquiniloxi, C1-C6-haloalcoxi y C1-C6-alquiltio, C(O)NR3aR3b o C(O)NR4aR4b, (SO2)NR3aR3b o (SO2)NR4aR4b, fenilo, feniloxi o bencilo, pudiendo cada uno de los tres ultimos radicales mencionados no llevar sustituyente o estar sustituido con 1 a 5 radicales, seleccionados cada vez independientemente del grupo, que consiste de: halogeno, C1-C6-alquilo, C1-C6-haloalquilo, C1-C6-alquiltio, C1-C6-haloalquiltio, C1-C6-alcoxi y C1-C6- haloalcoxi radicales; y donde R3a, R4a y R3b, R4b son cada vez independientemente seleccionados entre hidrogeno, C1-C6-alquilo, C1-C6-haloalquilo, C2-C6-alquenilo, o C2-C6-alquinilo; R3c, R4c son cada vez independientemente seleccionados entre hidrogeno, C1-C6-alquilo, C2-C6-alquenilo, C2-C6-alquinilo, C3-C8-cicloalquilo, C1-C6-alquiltio, C1-C6-alcoxi, (C1-C6-alquil)amino, di(C1-C6-alquil)amino, fenilo y heteroarilo, que pueden ser un anillo heteroaromático mono o bicíclico con con 5 a 10 miembros, que contiene 1, 2, 3 o 4 heteroátomos seleccionados entre O, S y N; siendo preciso que al menos uno de R3 y R4 es hidrogeno; o los enantiomeros y la sal aceptable en la agricultura y veterianria de los mismos, siendo preciso, que el compuesto de la formula I no represente un derivado de 3-(1,2,3,4-tetrahidro-1-naftil)-tio-urea, donde (R1)m,R3 y R4 significan hidrogeno y R2 es hidrogeno o R2 es CH3.
ARP060105202A 2005-11-25 2006-11-24 Compuestos de indanil- y tetrahidronaftil-amino-tiourea para combatir pestes animales AR056818A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73972905P 2005-11-25 2005-11-25

Publications (1)

Publication Number Publication Date
AR056818A1 true AR056818A1 (es) 2007-10-24

Family

ID=37744627

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105202A AR056818A1 (es) 2005-11-25 2006-11-24 Compuestos de indanil- y tetrahidronaftil-amino-tiourea para combatir pestes animales

Country Status (20)

Country Link
US (1) US7674827B2 (es)
EP (1) EP1957447A1 (es)
JP (1) JP5250422B2 (es)
KR (1) KR20080072067A (es)
CN (1) CN101312945A (es)
AP (1) AP2008004520A0 (es)
AR (1) AR056818A1 (es)
AU (1) AU2006316540A1 (es)
BR (1) BRPI0618968A2 (es)
CA (1) CA2627988A1 (es)
CR (1) CR10013A (es)
EC (1) ECSP088556A (es)
IL (1) IL191163A0 (es)
MA (1) MA30080B1 (es)
PE (1) PE20070797A1 (es)
RU (1) RU2008125300A (es)
TW (1) TW200806616A (es)
UY (1) UY29973A1 (es)
WO (1) WO2007060120A1 (es)
ZA (1) ZA200805452B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI324908B (en) * 2006-01-05 2010-05-21 Du Pont Liquid formulations of carboxamide arthropodicides
GB0614552D0 (en) * 2006-07-21 2006-08-30 Syngenta Ltd Chemical Compounds
EP1977646A1 (en) * 2007-04-03 2008-10-08 Bayer CropScience AG Insecticidal hydroxyethyl thlourea derivatives
WO2008141980A1 (en) 2007-05-24 2008-11-27 Basf Se Substituted amino-thiourea compounds for combating animal pests
WO2010070035A1 (en) * 2008-12-18 2010-06-24 Basf Se Thiourea compounds for combating invertebrate pests
CN102558003B (zh) * 2011-12-29 2013-11-20 浙江大学 1,1,3,3-四甲基硫脲的制备方法
US10556878B2 (en) 2013-06-06 2020-02-11 Cornell University Thiourea compounds and their use as inhibitors of Sirt2 or Sirt5
MX2021011980A (es) * 2019-05-31 2021-11-03 Firmenich & Cie Composicion de control de artropodos.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479544A (en) * 1974-02-07 1977-07-13 American Cyanamid Co 1,2,3,4-tetrahydro-1-naphthylurea derivatives their preparation and their use
US3953606A (en) 1974-02-07 1976-04-27 American Cyanamid Company Compositions and method of using ureidotetralin compounds or derivatives thereof
US3953506A (en) 1974-02-07 1976-04-27 American Cyanamid Company Ureidotetralin compounds
US4005140A (en) 1974-02-07 1977-01-25 American Cyanamid Company Ureidotetralin compounds
US4062856A (en) 1976-01-26 1977-12-13 American Cyanamid Co. Ureidotetralin compounds
US4971994A (en) * 1988-04-20 1990-11-20 Ciba-Geigy Corporation Thioureas
FR2679555B1 (fr) * 1991-07-25 1993-11-19 Fabre Medicament Pierre Nouveaux derives de l'uree, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
ZA200805452B (en) 2009-10-28
US20090075819A1 (en) 2009-03-19
AP2008004520A0 (en) 2008-06-30
CR10013A (es) 2008-07-29
JP5250422B2 (ja) 2013-07-31
MA30080B1 (fr) 2008-12-01
RU2008125300A (ru) 2009-12-27
CN101312945A (zh) 2008-11-26
BRPI0618968A2 (pt) 2013-01-08
TW200806616A (en) 2008-02-01
US7674827B2 (en) 2010-03-09
UY29973A1 (es) 2007-06-29
PE20070797A1 (es) 2007-09-27
EP1957447A1 (en) 2008-08-20
IL191163A0 (en) 2008-12-29
KR20080072067A (ko) 2008-08-05
CA2627988A1 (en) 2007-05-31
WO2007060120A1 (en) 2007-05-31
JP2009517362A (ja) 2009-04-30
AU2006316540A1 (en) 2007-05-31
ECSP088556A (es) 2008-07-30

Similar Documents

Publication Publication Date Title
AR056818A1 (es) Compuestos de indanil- y tetrahidronaftil-amino-tiourea para combatir pestes animales
AR056819A1 (es) Compuestos de indanil- y tetrahidronaftil-amino-azolina para combatir pestes animales
CO2018006299A2 (es) Compuestos novedosos
CY1118191T1 (el) Αναλογα δεοξυνοζιριμυκινης και οι χρησεις τους ως αναστολεις γλυκοζυλοκεραμιδασης
AR108557A1 (es) Uracilpiridinas herbicidas
AR060150A1 (es) Heteropentaciclos activos como inhibidores de quinasas, y su uso para tratar trastornos de la proliferacion celular
ECSP12011880A (es) INHIBIDORES DE N1-PIRAZOLOESPIROCETONA ACETIL-CoA CARBOXILASA
WO2006091394A3 (en) Substituted imidazoquinolines and imidazonaphthyridines
DK1901729T3 (da) Farmaceutiske formuleringer af HDAC-inhibitorer
NO20076093L (no) Substituerte amidderivater som proteinkinaseinhibitorer
WO2006038923A3 (en) Aryl substituted imidazonaphthyridines
AR060421A1 (es) Derivados de nitrocatecol sustituidos
AR043057A1 (es) Compuestos derivados de piridintiazoles como inhibidores de la quinasa rock y otras proteinas quinasa
SG149829A1 (en) Pyrazolopyridines and analogs thereof
AR016429A1 (es) Compuesto derivado de acido hidroxamico como inhibidores de metaloproteasa de matriz (mmp), composiciones farmaceuticas y formulaciones veterinarias, usopara la preparacion de composiciones y formulaciones, compuesto intermediario, procedimiento de preparacion del compuesto.
PE20141182A1 (es) Derivados fusionados de aminodihidrotiazina
TW200639172A (en) Pyrazolopyridines and analogs thereof
DE60321775D1 (de) Carbaminsäurederivate enthaltend eine piperazin verknüpfung als hdac-inhibitoren
DE60315677D1 (de) Pyrazolopyridin derivate als tgf beta hemmstoffe zur behandlung von krebs
UY27619A1 (es) Ésteres hidroxamato del ácido n-(4-fenil sustituido)- antranílico
AR054125A1 (es) Derivados del fluoreno, composiciones farmaceuticas que los contienen y su utilizacion en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por la actividad de la proteina hsp90
ES2162676T3 (es) Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3.
SG149828A1 (en) Alkoxy substituted imidazoquinolines
BR112016028642A2 (pt) composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo.
AR114807A1 (es) Plantas que tienen una mayor tolerancia a herbicidas

Legal Events

Date Code Title Description
FB Suspension of granting procedure