AR055196A1 - Derivados de tienopiridina, procesos de obtencion y composiciones farmaceuticas. - Google Patents

Derivados de tienopiridina, procesos de obtencion y composiciones farmaceuticas.

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Publication number
AR055196A1
AR055196A1 ARP060100754A ARP060100754A AR055196A1 AR 055196 A1 AR055196 A1 AR 055196A1 AR P060100754 A ARP060100754 A AR P060100754A AR P060100754 A ARP060100754 A AR P060100754A AR 055196 A1 AR055196 A1 AR 055196A1
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AR
Argentina
Prior art keywords
hai
atoms
so2a
nha
naa
Prior art date
Application number
ARP060100754A
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English (en)
Inventor
Hans-Michael Eggenweiler
Michael Wolf
Original Assignee
Merck Patent Gmbh
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Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR055196A1 publication Critical patent/AR055196A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P31/20—Antivirals for DNA viruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Transplantation (AREA)

Abstract

Los derivados de tienopiridina de la formula (1), en donde: Y es OH, OA, SH, SA, NH2, NHA o NAA'; R1 es HaI, OH, OA, SH, SA, H o A; R2 es H, Hal o -O-(X)s-Q; R3 es H, HaI, CN, NO2, A, OH, OA, SH, SA, (CH2)nCOOH, (CH2)nCOOA, CONH2, CONHA, CONAA', NH2, NHA, NAA', NHCOOA, NHCONH2, NHCONHA, SOA, SO2A, SO2NH2, SO2NHA o SO2NAA'; dos radicales adyacentes, seleccionados del grupo R1, R2, R3, juntos también son metilendioxi o etilendioxi; A, A' son cada uno de modo independiente entre sí alquilo no ramificado o ramificado con 1-10 átomos de C, en donde 1-5 átomos de H pueden estar reemplazados por F y/o Cl, Alk o alquilo cíclico con 3-7 átomos de C; A y A' juntos también son una cadena alquileno con 2, 3, 4, 5 o 6 átomos de C, en donde un grupo CH2 puede estar reemplazado por O, S, SO, SO2, NH, NA o N-COOA; Alk es alquenilo con 2-6 átomos de C; X es alquileno C1-10 o alquenileno ramificado o no ramificado, no substituido o mono-, di-, tri-, o tetrasubstituido con A, OA, OH, SH, SA, HaI, NO2, CN, Ar, OAr, COOH, COOA, CHO, C(=O)A, C(=O)Ar, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHCONAA', NACONAA' y/u =O, en donde también, uno, dos o tres grupos C pueden estar reemplazados con O, S, SO, SO2 y/o con grupos NH; Q es H, Carb, Ar o Het; Carb es cicloalquilo con 3-7 átomos de C, o cicloalquenilo con 3-7 átomos de C, no substituido o mono-, di-, tri-, tetra- o pentasubtituido con A, OA, OH, SH, SA, HaI, NO2, CN, (CH2)nAr', (CH2)nCOOH, (CH2)nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHCONAA' o NACONAA'; Ar es fenilo, naftilo o bifenilo no substituido o mono-, di-, tri-, tetra- o penta substituido con A, OA, OH, SH, SA, HaI, NO2, CN, (CH2)nAr', (CH2)nCOOH, (CH2)nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHCONAA' o NACONAA'; Ar' es fenilo, naftilo o bifenilo no substituido o mono-, di-, trisubstituido con A, OA, OH, SH, SA, HaI, NO2, CN, (CH2)nfenilo, (CH2)nCOOH, (CH2)nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHCONAA' o NACONAA'; Het es un heterociclo mono- o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede estar mono-, di-, o trisubstituido con A, OA, OH, SH, SA, HaI, NO2, CN, (CH2)nAr', (CH2)nCOOH, (CH2) nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHCONAA', NACONAA', SO2A, =S, =NH, =NA y/u =O (oxígeno del carbonilo); HaI es F, Cl, Br o I; n es 0, 1, 2, 3 o 4; s es 0 o 1 , así como sus derivados, sales, solvatos, tautomeros y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas sus proporciones. Son inhibidores de la HSP90 y pueden ser utilizados para preparar un medicamento para el tratamiento de enfermedades en las que la inhibicion, la regulacion y/o la modulacion de la HSP90 desempena un papel importante.
ARP060100754A 2005-03-02 2006-03-01 Derivados de tienopiridina, procesos de obtencion y composiciones farmaceuticas. AR055196A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005009440A DE102005009440A1 (de) 2005-03-02 2005-03-02 Thienopyridinderivate

Publications (1)

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AR055196A1 true AR055196A1 (es) 2007-08-08

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EP (1) EP1853609B1 (es)
JP (1) JP5054545B2 (es)
KR (1) KR20070107092A (es)
CN (1) CN101133063A (es)
AR (1) AR055196A1 (es)
AU (1) AU2006220095B2 (es)
BR (1) BRPI0607560A2 (es)
CA (1) CA2599826C (es)
DE (1) DE102005009440A1 (es)
DK (1) DK1853609T3 (es)
ES (1) ES2462923T3 (es)
MX (1) MX2007010562A (es)
PT (1) PT1853609E (es)
RU (1) RU2007136165A (es)
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CN101133063A (zh) 2008-02-27
ZA200708371B (en) 2009-07-29
US20090054452A1 (en) 2009-02-26
JP5054545B2 (ja) 2012-10-24
WO2006092202A1 (de) 2006-09-08
CA2599826C (en) 2013-09-24
JP2008531611A (ja) 2008-08-14
KR20070107092A (ko) 2007-11-06
AU2006220095A1 (en) 2006-09-08
BRPI0607560A2 (pt) 2009-09-15
ES2462923T3 (es) 2014-05-26
MX2007010562A (es) 2007-10-04
EP1853609B1 (de) 2014-04-02
EP1853609A1 (de) 2007-11-14
DK1853609T3 (da) 2014-06-10
AU2006220095B2 (en) 2012-02-02
CA2599826A1 (en) 2006-09-08
US7943637B2 (en) 2011-05-17
RU2007136165A (ru) 2009-04-10
DE102005009440A1 (de) 2006-09-07
PT1853609E (pt) 2014-06-25

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