AR054467A1 - Metodo para inhibir las enzimas beta-lactamasas de clase d en el tratamiento de infeccion bacteriana en un paciente - Google Patents
Metodo para inhibir las enzimas beta-lactamasas de clase d en el tratamiento de infeccion bacteriana en un pacienteInfo
- Publication number
- AR054467A1 AR054467A1 ARP060102292A ARP060102292A AR054467A1 AR 054467 A1 AR054467 A1 AR 054467A1 AR P060102292 A ARP060102292 A AR P060102292A AR P060102292 A ARP060102292 A AR P060102292A AR 054467 A1 AR054467 A1 AR 054467A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- beta
- class
- enzymes
- optionally substituted
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Penemes tricíclicos de 6-alquilideno con actividad como inhibidores de enzimas clases D. Las beta-lactamasas hidrolizan los antibioticos beta-lactámicos, y como tales sirven como la causa primaria de resistencia bacteriana cuando se combinan con los antibioticos beta-lactama, los compuestos de la presente suministran un tratamiento efectivo contra las infecciones bacteriales que amenazan la vida. Estos compuestos suministrados son de formula (1), son utiles para el tratamiento de infecciones bacterianas que tienen asociada junto con esta la enzima Clase D, en donde: uno de A y B denota hidrogeno y el otro grupo heteroarilo tricíclicos fusionado opcionalmente sustituido; y X es S u O. Reivindicacion 1: Un método para inhibir las enzimas de Clase D en el tratamiento de para inhibir las enzimas de Clase D en el tratamiento de infeccion bacterial en un paciente en necesidad de éste, caracterizado por comprender suministrar una cantidad efectiva de un compuesto de formula (1), en donde: uno de A y B denotan hidrogeno y el otro un grupo heteroarilo tricíclico fusionado opcionalmente sustituido; X es S u O; R5 es H, alquilo C1-6, cicloalquilo C5-6, alquiloC1-6CHR30CO; y R3 es hidrogeno, alquilo C1-6, cicloalquilo C5-6, arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; o una sal farmacéuticamente aceptable o éster hidrolizable in vivo de esta.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68622105P | 2005-06-01 | 2005-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054467A1 true AR054467A1 (es) | 2007-06-27 |
Family
ID=37836305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102292A AR054467A1 (es) | 2005-06-01 | 2006-06-01 | Metodo para inhibir las enzimas beta-lactamasas de clase d en el tratamiento de infeccion bacteriana en un paciente |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060276446A1 (es) |
| EP (1) | EP1885358A2 (es) |
| JP (1) | JP2008542376A (es) |
| CN (1) | CN101189010A (es) |
| AR (1) | AR054467A1 (es) |
| AU (1) | AU2006287938A1 (es) |
| BR (1) | BRPI0611491A2 (es) |
| CA (1) | CA2610478A1 (es) |
| GT (1) | GT200600235A (es) |
| MX (1) | MX2007015173A (es) |
| PE (1) | PE20070010A1 (es) |
| SV (1) | SV2007002555A (es) |
| TW (1) | TW200716104A (es) |
| WO (1) | WO2007030166A2 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| TW200716102A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| US8524304B2 (en) | 2005-11-23 | 2013-09-03 | The Coca-Cola Company | High-potency sweetener composition with probiotics/prebiotics and compositions sweetened therewith |
| US8512789B2 (en) | 2005-11-23 | 2013-08-20 | The Coca-Cola Company | High-potency sweetener composition with dietary fiber and compositions sweetened therewith |
| US8945652B2 (en) | 2005-11-23 | 2015-02-03 | The Coca-Cola Company | High-potency sweetener for weight management and compositions sweetened therewith |
| JP2012121809A (ja) * | 2009-02-26 | 2012-06-28 | Eisai R & D Management Co Ltd | 多環式化合物の製造法およびその中間体 |
| US20110288063A1 (en) * | 2010-05-19 | 2011-11-24 | Naeja Pharmaceutical Inc. | Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors |
| CN104341345B (zh) * | 2014-10-24 | 2016-03-23 | 海门海康生物医药科技有限公司 | 一种2-甲氧基-6-酮-5,6,7,8-四氢喹啉的合成方法 |
| JP7413346B2 (ja) | 2019-03-06 | 2024-01-15 | 第一三共株式会社 | ピロロピラゾール誘導体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995028935A1 (en) * | 1994-04-25 | 1995-11-02 | Smithkline Beecham Plc | Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections |
| US20040132706A1 (en) * | 2001-10-05 | 2004-07-08 | Daniela Salvemini | Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| US20040132708A1 (en) * | 2002-05-01 | 2004-07-08 | Wyeth | Process for preparing 6-alkylidene penem derivatives |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| TW200716102A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
-
2006
- 2006-05-22 TW TW095118171A patent/TW200716104A/zh unknown
- 2006-05-25 JP JP2008514712A patent/JP2008542376A/ja not_active Withdrawn
- 2006-05-25 BR BRPI0611491-1A patent/BRPI0611491A2/pt not_active IP Right Cessation
- 2006-05-25 WO PCT/US2006/020410 patent/WO2007030166A2/en active Application Filing
- 2006-05-25 EP EP06824758A patent/EP1885358A2/en not_active Withdrawn
- 2006-05-25 MX MX2007015173A patent/MX2007015173A/es unknown
- 2006-05-25 CA CA002610478A patent/CA2610478A1/en not_active Abandoned
- 2006-05-25 CN CNA2006800193154A patent/CN101189010A/zh active Pending
- 2006-05-25 AU AU2006287938A patent/AU2006287938A1/en not_active Abandoned
- 2006-05-31 SV SV2006002555A patent/SV2007002555A/es unknown
- 2006-05-31 PE PE2006000563A patent/PE20070010A1/es not_active Application Discontinuation
- 2006-05-31 US US11/444,346 patent/US20060276446A1/en not_active Abandoned
- 2006-06-01 GT GT200600235A patent/GT200600235A/es unknown
- 2006-06-01 AR ARP060102292A patent/AR054467A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007030166A2 (en) | 2007-03-15 |
| CN101189010A (zh) | 2008-05-28 |
| AU2006287938A1 (en) | 2007-03-15 |
| GT200600235A (es) | 2007-03-29 |
| EP1885358A2 (en) | 2008-02-13 |
| BRPI0611491A2 (pt) | 2010-12-21 |
| US20060276446A1 (en) | 2006-12-07 |
| CA2610478A1 (en) | 2007-03-15 |
| SV2007002555A (es) | 2007-02-02 |
| WO2007030166A3 (en) | 2007-05-24 |
| MX2007015173A (es) | 2008-02-15 |
| JP2008542376A (ja) | 2008-11-27 |
| PE20070010A1 (es) | 2007-01-12 |
| TW200716104A (en) | 2007-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |