AR052479A1 - Polimorfo del 42-ester de rapamicina con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) y su uso - Google Patents
Polimorfo del 42-ester de rapamicina con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) y su usoInfo
- Publication number
- AR052479A1 AR052479A1 ARP060100451A ARP060100451A AR052479A1 AR 052479 A1 AR052479 A1 AR 052479A1 AR P060100451 A ARP060100451 A AR P060100451A AR P060100451 A ARP060100451 A AR P060100451A AR 052479 A1 AR052479 A1 AR 052479A1
- Authority
- AR
- Argentina
- Prior art keywords
- cci
- polymorph
- degree
- hydroximethyl
- rapamycin
- Prior art date
Links
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title abstract 7
- 229960000235 temsirolimus Drugs 0.000 title abstract 7
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- 229960002930 sirolimus Drugs 0.000 title 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 2
- 238000000113 differential scanning calorimetry Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000002411 thermogravimetry Methods 0.000 abstract 1
- 238000001757 thermogravimetry curve Methods 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65137405P | 2005-02-09 | 2005-02-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052479A1 true AR052479A1 (es) | 2007-03-21 |
Family
ID=36570939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100451A AR052479A1 (es) | 2005-02-09 | 2006-02-08 | Polimorfo del 42-ester de rapamicina con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) y su uso |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7442707B2 (enExample) |
| EP (1) | EP1856130A1 (enExample) |
| JP (1) | JP2008530090A (enExample) |
| KR (1) | KR20070107030A (enExample) |
| CN (1) | CN101115759A (enExample) |
| AR (1) | AR052479A1 (enExample) |
| AU (1) | AU2006213061A1 (enExample) |
| BR (1) | BRPI0607932A2 (enExample) |
| CA (1) | CA2595766A1 (enExample) |
| CR (1) | CR9257A (enExample) |
| GT (1) | GT200600044A (enExample) |
| IL (1) | IL184560A0 (enExample) |
| MX (1) | MX2007009590A (enExample) |
| NO (1) | NO20073725L (enExample) |
| PE (1) | PE20060996A1 (enExample) |
| RU (1) | RU2007129264A (enExample) |
| TW (1) | TW200638932A (enExample) |
| WO (1) | WO2006086172A1 (enExample) |
| ZA (1) | ZA200706628B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8551512B2 (en) * | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
| JP2009518648A (ja) * | 2005-12-07 | 2009-05-07 | ワイス | 結晶性ラパマイシンを調製するための方法およびを示差走査熱量測定使用してラパマイシン化合物の結晶化度を測定するための方法 |
| PE20070748A1 (es) * | 2005-12-07 | 2007-08-08 | Wyeth Corp | Proceso ajustable a escala para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina |
| AR058282A1 (es) * | 2005-12-07 | 2008-01-30 | Wyeth Corp | Forma cristalina purificada de cci-779, un proceso para la preparacion del mismo, un metodo para monitorear la cristalizacion del cci-779, un kit y una composicion farmaceutica que lo comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer. |
| TW200824713A (en) * | 2006-10-18 | 2008-06-16 | Wyeth Corp | Processes for the synthesis of individual isomers of mono-PEG CCI-779 |
| CA2749807C (en) * | 2009-01-21 | 2015-09-29 | Biocon Limited | A method for determination of sirolimus stability and process for preparing its stable form |
| US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
| CN109020995A (zh) * | 2017-06-12 | 2018-12-18 | 鲁南制药集团股份有限公司 | 一种替西罗莫司的晶型物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| TWI256395B (en) | 1999-09-29 | 2006-06-11 | Wyeth Corp | Regioselective synthesis of rapamycin derivatives |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| US6680330B2 (en) * | 2001-08-22 | 2004-01-20 | Wyeth | Rapamycin dialdehydes |
| EP1419154B1 (en) * | 2001-08-22 | 2005-10-05 | Wyeth | Rapamycin 29-enols |
| EP1646635A1 (en) | 2003-07-16 | 2006-04-19 | Wyeth | Cci-779 isomer c |
| JP4227649B2 (ja) | 2003-08-07 | 2009-02-18 | ワイス | Ｃｃｉ−７７９の位置選択的合成 |
| EP1660081A1 (en) * | 2003-09-03 | 2006-05-31 | Wyeth | Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and pharmaceutical compositions containing the same |
| KR20070015544A (ko) * | 2004-04-14 | 2007-02-05 | 와이어쓰 | 라파마이신 42-에스테르 유도체의 위치특이성 합성 |
-
2006
- 2006-01-25 JP JP2007555124A patent/JP2008530090A/ja not_active Withdrawn
- 2006-01-25 AU AU2006213061A patent/AU2006213061A1/en not_active Abandoned
- 2006-01-25 MX MX2007009590A patent/MX2007009590A/es not_active Application Discontinuation
- 2006-01-25 CN CNA200680004408XA patent/CN101115759A/zh not_active Withdrawn
- 2006-01-25 KR KR1020077018347A patent/KR20070107030A/ko not_active Withdrawn
- 2006-01-25 CA CA002595766A patent/CA2595766A1/en not_active Abandoned
- 2006-01-25 US US11/339,728 patent/US7442707B2/en not_active Expired - Fee Related
- 2006-01-25 EP EP06734012A patent/EP1856130A1/en not_active Withdrawn
- 2006-01-25 WO PCT/US2006/003098 patent/WO2006086172A1/en not_active Ceased
- 2006-01-25 BR BRPI0607932A patent/BRPI0607932A2/pt not_active IP Right Cessation
- 2006-01-25 RU RU2007129264/04A patent/RU2007129264A/ru not_active Application Discontinuation
- 2006-02-03 PE PE2006000136A patent/PE20060996A1/es not_active Application Discontinuation
- 2006-02-06 TW TW095103902A patent/TW200638932A/zh unknown
- 2006-02-07 GT GT200600044A patent/GT200600044A/es unknown
- 2006-02-08 AR ARP060100451A patent/AR052479A1/es unknown
-
2007
- 2007-07-12 IL IL184560A patent/IL184560A0/en unknown
- 2007-07-18 CR CR9257A patent/CR9257A/es not_active Application Discontinuation
- 2007-07-18 NO NO20073725A patent/NO20073725L/no not_active Application Discontinuation
- 2007-08-08 ZA ZA200706628A patent/ZA200706628B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL184560A0 (en) | 2007-10-31 |
| EP1856130A1 (en) | 2007-11-21 |
| RU2007129264A (ru) | 2009-03-20 |
| KR20070107030A (ko) | 2007-11-06 |
| AU2006213061A1 (en) | 2006-08-17 |
| GT200600044A (es) | 2006-11-09 |
| BRPI0607932A2 (pt) | 2016-11-08 |
| ZA200706628B (en) | 2010-01-27 |
| CA2595766A1 (en) | 2006-08-17 |
| CN101115759A (zh) | 2008-01-30 |
| TW200638932A (en) | 2006-11-16 |
| WO2006086172A1 (en) | 2006-08-17 |
| JP2008530090A (ja) | 2008-08-07 |
| MX2007009590A (es) | 2007-09-12 |
| PE20060996A1 (es) | 2006-11-13 |
| US20060178392A1 (en) | 2006-08-10 |
| US7442707B2 (en) | 2008-10-28 |
| NO20073725L (no) | 2007-09-05 |
| CR9257A (es) | 2007-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |