MX2007009590A - Polimorfo cci-779 y uso del mismo. - Google Patents
Polimorfo cci-779 y uso del mismo.Info
- Publication number
- MX2007009590A MX2007009590A MX2007009590A MX2007009590A MX2007009590A MX 2007009590 A MX2007009590 A MX 2007009590A MX 2007009590 A MX2007009590 A MX 2007009590A MX 2007009590 A MX2007009590 A MX 2007009590A MX 2007009590 A MX2007009590 A MX 2007009590A
- Authority
- MX
- Mexico
- Prior art keywords
- cci
- polymorph form
- polymorph
- solid
- further characterized
- Prior art date
Links
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- 208000037803 restenosis Diseases 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 229940083575 sodium dodecyl sulfate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Chemical class 0.000 description 1
- 229920003109 sodium starch glycolate Chemical class 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 150000005671 trienes Chemical class 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65137405P | 2005-02-09 | 2005-02-09 | |
| PCT/US2006/003098 WO2006086172A1 (en) | 2005-02-09 | 2006-01-25 | Cci-779 polymorph and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007009590A true MX2007009590A (es) | 2007-09-12 |
Family
ID=36570939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007009590A MX2007009590A (es) | 2005-02-09 | 2006-01-25 | Polimorfo cci-779 y uso del mismo. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7442707B2 (enExample) |
| EP (1) | EP1856130A1 (enExample) |
| JP (1) | JP2008530090A (enExample) |
| KR (1) | KR20070107030A (enExample) |
| CN (1) | CN101115759A (enExample) |
| AR (1) | AR052479A1 (enExample) |
| AU (1) | AU2006213061A1 (enExample) |
| BR (1) | BRPI0607932A2 (enExample) |
| CA (1) | CA2595766A1 (enExample) |
| CR (1) | CR9257A (enExample) |
| GT (1) | GT200600044A (enExample) |
| IL (1) | IL184560A0 (enExample) |
| MX (1) | MX2007009590A (enExample) |
| NO (1) | NO20073725L (enExample) |
| PE (1) | PE20060996A1 (enExample) |
| RU (1) | RU2007129264A (enExample) |
| TW (1) | TW200638932A (enExample) |
| WO (1) | WO2006086172A1 (enExample) |
| ZA (1) | ZA200706628B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8551512B2 (en) * | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
| RU2008120670A (ru) * | 2005-12-07 | 2010-01-20 | Вайет (Us) | Масштабируемый способ получения 42-сложного эфира рапамицина из 42-сложного эфира рапамицина бороната |
| RU2008120712A (ru) * | 2005-12-07 | 2010-01-20 | Вайет (Us) | Способы получения кристаллического рапамицина и определения кристалличности соединений рапамицина при помощи дифференциальной сканирующей калориметрии |
| KR20080077618A (ko) * | 2005-12-07 | 2008-08-25 | 와이어쓰 | 정제된 결정체 ｃｃｉ-779 의 제조 방법 |
| TW200824713A (en) * | 2006-10-18 | 2008-06-16 | Wyeth Corp | Processes for the synthesis of individual isomers of mono-PEG CCI-779 |
| CN102282457A (zh) * | 2009-01-21 | 2011-12-14 | 拜康有限公司 | 确定西罗莫司稳定性的方法和制备其稳定形式的工艺 |
| US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
| CN109020995A (zh) * | 2017-06-12 | 2018-12-18 | 鲁南制药集团股份有限公司 | 一种替西罗莫司的晶型物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| TWI256395B (en) | 1999-09-29 | 2006-06-11 | Wyeth Corp | Regioselective synthesis of rapamycin derivatives |
| CA2455311A1 (en) | 2001-08-22 | 2003-03-06 | Wyeth | Rapamycin dialdehydes |
| EP1419154B1 (en) | 2001-08-22 | 2005-10-05 | Wyeth | Rapamycin 29-enols |
| WO2005010010A1 (en) | 2003-07-16 | 2005-02-03 | Wyeth | Cci-779 isomer c |
| PT1658295E (pt) * | 2003-08-07 | 2007-09-25 | Wyeth Corp | Síntese regiosselectiva de cci-779 |
| AU2004270154A1 (en) * | 2003-09-03 | 2005-03-17 | Wyeth | Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same |
| EP1737869A1 (en) * | 2004-04-14 | 2007-01-03 | Wyeth a Corporation of the State of Delaware | Regiospecific synthesis of rapamycin 42-ester derivatives |
-
2006
- 2006-01-25 EP EP06734012A patent/EP1856130A1/en not_active Withdrawn
- 2006-01-25 US US11/339,728 patent/US7442707B2/en not_active Expired - Fee Related
- 2006-01-25 RU RU2007129264/04A patent/RU2007129264A/ru not_active Application Discontinuation
- 2006-01-25 AU AU2006213061A patent/AU2006213061A1/en not_active Abandoned
- 2006-01-25 CA CA002595766A patent/CA2595766A1/en not_active Abandoned
- 2006-01-25 BR BRPI0607932A patent/BRPI0607932A2/pt not_active IP Right Cessation
- 2006-01-25 WO PCT/US2006/003098 patent/WO2006086172A1/en not_active Ceased
- 2006-01-25 CN CNA200680004408XA patent/CN101115759A/zh not_active Withdrawn
- 2006-01-25 KR KR1020077018347A patent/KR20070107030A/ko not_active Withdrawn
- 2006-01-25 JP JP2007555124A patent/JP2008530090A/ja not_active Withdrawn
- 2006-01-25 MX MX2007009590A patent/MX2007009590A/es not_active Application Discontinuation
- 2006-02-03 PE PE2006000136A patent/PE20060996A1/es not_active Application Discontinuation
- 2006-02-06 TW TW095103902A patent/TW200638932A/zh unknown
- 2006-02-07 GT GT200600044A patent/GT200600044A/es unknown
- 2006-02-08 AR ARP060100451A patent/AR052479A1/es unknown
-
2007
- 2007-07-12 IL IL184560A patent/IL184560A0/en unknown
- 2007-07-18 CR CR9257A patent/CR9257A/es not_active Application Discontinuation
- 2007-07-18 NO NO20073725A patent/NO20073725L/no not_active Application Discontinuation
- 2007-08-08 ZA ZA200706628A patent/ZA200706628B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060178392A1 (en) | 2006-08-10 |
| JP2008530090A (ja) | 2008-08-07 |
| NO20073725L (no) | 2007-09-05 |
| WO2006086172A1 (en) | 2006-08-17 |
| GT200600044A (es) | 2006-11-09 |
| CN101115759A (zh) | 2008-01-30 |
| CA2595766A1 (en) | 2006-08-17 |
| AU2006213061A1 (en) | 2006-08-17 |
| KR20070107030A (ko) | 2007-11-06 |
| RU2007129264A (ru) | 2009-03-20 |
| AR052479A1 (es) | 2007-03-21 |
| US7442707B2 (en) | 2008-10-28 |
| TW200638932A (en) | 2006-11-16 |
| BRPI0607932A2 (pt) | 2016-11-08 |
| EP1856130A1 (en) | 2007-11-21 |
| CR9257A (es) | 2007-11-23 |
| IL184560A0 (en) | 2007-10-31 |
| PE20060996A1 (es) | 2006-11-13 |
| ZA200706628B (en) | 2010-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |