AR050644A1 - Derivados de anilina sustituidos - Google Patents

Derivados de anilina sustituidos

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Publication number
AR050644A1
AR050644A1 ARP050103796A ARP050103796A AR050644A1 AR 050644 A1 AR050644 A1 AR 050644A1 AR P050103796 A ARP050103796 A AR P050103796A AR P050103796 A ARP050103796 A AR P050103796A AR 050644 A1 AR050644 A1 AR 050644A1
Authority
AR
Argentina
Prior art keywords
alky
cycloalk
ilo
alkyl
cycloalkyl
Prior art date
Application number
ARP050103796A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36654136&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR050644(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR050644A1 publication Critical patent/AR050644A1/es

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    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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  • Furan Compounds (AREA)

Abstract

La presente se refiere a derivados de anilina de la formula general (1) o a las sales de los mismos y su uso, por ejemplo para aumentar el flujo de iones en un canal de potasio en un mamífero. Reivindicacion 1: Un compuesto que tiene la formula general (1) o sales del mismo en donde Z es O o S; y q es 0 o 1; y cada uno de R1 y R2 es seleccionado independientemente del grupo que consiste en halogeno, ciano, amino, C1-6-alqu(en/in)ilo, C3-8-cicloalqu(en)ilo, C3-8-cicloalqu(en)il-C1-6- alqu(en/in)ilo, C3-8-heterocicloalqu(en)ilo, arilo, heteroarilo, halo-C1-6-alqu(en/in)ilo, halo-C3-8-cicloalqu(en)ilo, halo-C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, C1-6-alqu(en/in)iloxi, C3-8-cicloalqu(en)iloxi, C3-8-cicloalqu(en)il-C1-6- alqu(en/in)iloxi, C3-8-heterocicloalqu(en)iloxi, y R3 es seleccionado del grupo que consiste en C1-8-alqu(en/in)ilo, C3-8-cicloalqu(en)ilo, C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, aril-C1-6-alqu(en/in)ilo, aril-C3-8-cicloalqu(en)ilo, aril-C3-8- cicloalqu(en)il-C1-6-alqu(en/in)ilo, C3-8-heterocicloalqu(en)il-C1-6-alqu(en/in)ilo, C1-6-alqu(en/in)il-C3-8-heterocicloalqu(en)il-C1-6-alqu(en/in)ilo, heteroaril-C1-6-alqu(en/in)ilo, heteroaril-C3-8-cicloalqu(en)ilo, heteroaril-C3-8-cicloalqu(en)il- C1-6-alqu(en/in)ilo, amino-C1-6-alqu(en/in)ilo, amino-C3-8-cicloalqu(en)ilo, amino-C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, C1-6-alqu(en/in)iloxi-C1-6-alqu(en/in)ilo, C3-8-cicloalqu(en)iloxi-C1-6-alqu(en/in)ilo, C3-8-cicloalqu(en)il-C1-6- alqu(en/in)iloxi-C1-6-alqu(en/in)ilo, halo-C1-6-alqu(en/in)ilo, halo-C3-8-cicloalqu(en)ilo, halo-C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, y R4 es seleccionado del grupo que consiste en halogeno, ciano, C1-6-alqu(en/in)ilo, C3-8-cicloalqu(en)ilo, C3- 8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, C3-8-heterocicloalqu(en)ilo, arilo, heteroarilo, aril-C3-8-cicloalqu(en)ilo, aril-C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, aril-C3-8-heterocicloalqu(en)ilo, halo-C1-6-alqu(en/in)ilo, halo-C3-8- cicloalqu(en)ilo, halo-C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, halo-C1-6-alqu(en/in)ilo-C3-8-heterocicloalqu(en)il-C1-6-alqu(en/in)ilo, NR5R6 y R7NH-C1-6-alqu(en/in)ilo; en donde R5 y R6 son seleccionados independientemente del grupo que consiste en H, aril-C1-6-alqu(en/in)ilo, aril-C3-8-cicloalqu(en)ilo, aril-C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, C1-6-alqu(en/in)ilo, C3-8-cicloalqu(en)ilo, C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, heteroaril-C1-6-alqu(en/in)ilo, heteroaril-C3-8- cicloalqu(en)ilo y heteroaril-C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, con la condicion de que R5 y R6 no sean H al mismo tiempo; y R7 es seleccionado del grupo que consiste en C1-6-alqu(en/in)ilo, C3-8-cicloalqu(en)ilo, C3-8-cicloalqu(en)il-C1-6- alqu(en/in)ilo, arilo, halo-C1-6-alqu(en/in)ilo, halo-C3-8-cicloalqu(en)ilo, halo-C3-8-cicloalqu(en)il-C1-6-alqu(en/in)ilo, aril-C1-6-alqu(en/in)ilo, aril-C3-8-cicloalqu(en)ilo y heteroailo.
ARP050103796A 2004-09-13 2005-09-12 Derivados de anilina sustituidos AR050644A1 (es)

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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
MX2008009655A (es) * 2006-02-07 2008-09-03 Lundbeck & Co As H Metodo para tratar o reducir los sintomas de la esquizofrenia.
US7960436B2 (en) 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US8993593B2 (en) 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
AU2007288253B2 (en) 2006-08-23 2013-05-02 Xenon Pharmaceuticals Inc. Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
KR20090083479A (ko) 2006-11-28 2009-08-03 밸리언트 파마슈티컬즈 인터내셔널 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체
US20100137381A1 (en) 2007-05-03 2010-06-03 Neurosearch A/S Acetamide derivatives as potassium channel modulators
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US20100256145A1 (en) * 2007-08-01 2010-10-07 H. Lundbeck A/S Use of kcnq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
JP2011506390A (ja) * 2007-12-11 2011-03-03 ノイロサーチ アクティーゼルスカブ カリウムチャネル活性化因子として有用な、新規の２−ピロリジニル−３−アミド−６−アミノ−ピリジン誘導体
JP2011525538A (ja) * 2008-06-24 2011-09-22 バレアント プハルマセウトイカルス インターナショナル カリウムチャネルモジュレーターとして有用なベンジルオキシアニリド誘導体
AU2010256541B2 (en) * 2009-06-03 2016-03-10 Marquette University Modulation of KCNQ potassium channel activity for treatment of psychiatric disorders and the symptoms thereof
CN103073455B (zh) * 2011-10-25 2015-08-19 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
CN103508943B (zh) * 2012-06-29 2017-06-09 江苏先声药业有限公司 作为钾通道调节剂的化合物
PE20150354A1 (es) * 2012-07-10 2015-03-21 Bayer Pharma AG Metodos para preparar triazolopiridinas sustituidas
CN108250128A (zh) * 2012-09-27 2018-07-06 江苏先声药业有限公司 作为钾通道调节剂的化合物
CN105017085B (zh) 2014-04-28 2018-06-29 中国科学院上海药物研究所 一类kcnq钾通道激动剂、其制备方法和用途
CN104020195B (zh) * 2014-05-27 2016-03-09 安徽师范大学 双识别多巴胺印迹电化学传感器及其制备方法和应用
MX2017005044A (es) 2014-10-24 2017-07-04 Ono Pharmaceutical Co Activador de canales de kcnq2-5.
JP6197971B1 (ja) * 2016-04-22 2017-09-20 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤
JP6265313B1 (ja) * 2016-04-22 2018-01-24 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル活性化剤の結晶多形
CA3023340A1 (en) 2016-06-10 2017-12-14 Scifluor Life Sciences, Inc. Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives
EP3366683A1 (en) 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers
EP3724163A4 (en) 2017-12-13 2021-07-28 SciFluor Life Sciences, Inc. FLUORINE DERIVATIVES 4- (AMINO SUBSTITUTE) PHENYL CARBAMATE
CN110511220B (zh) * 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用
CN108707087B (zh) 2018-06-29 2020-10-16 河北医科大学 一种4-(对三氟甲基苄基)-3-氟-1,2,4三苯胺衍生物及其药物组合物与用途
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
WO2022211520A1 (ko) * 2021-04-02 2022-10-06 파렌키마바이오텍 주식회사 신규 화합물 및 이의 자가면역질환 치료 용도
CN116535353A (zh) * 2022-01-25 2023-08-04 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362992A (en) * 1965-05-27 1968-01-09 Schwartz Herbert Novel cycloalkenecarboxanilides
JPS5214745A (en) * 1975-07-23 1977-02-03 Yoshitomi Pharmaceut Ind Ltd Preparation of phenylcarbamic acid esters
NZ223847A (en) * 1987-04-01 1989-12-21 Janssen Pharmaceutica Nv Substituted piperazine derivatives and pharmaceutical compositions
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
JPH106578A (ja) * 1996-06-21 1998-01-13 Canon Inc 印刷装置および印刷制御方法
EP1119568B1 (en) * 1998-10-09 2004-02-18 Janssen Pharmaceutica N.V. 4,5-dihydro-isoxazole derivatives and their pharmaceutical use
US6372767B1 (en) * 1999-08-04 2002-04-16 Icagen, Inc. Benzanilides as potassium channel openers
MXPA04011594A (es) * 2002-05-29 2005-03-07 Hoffmann La Roche Derivados n-acilaminobenceno como inhibidores selectivos de monoamino oxidasa b.
MXPA05009282A (es) * 2003-03-14 2005-10-05 Lundbeck & Co As H Derivados de anilina sustituidos.
JP4551667B2 (ja) * 2003-09-26 2010-09-29 富士フイルム株式会社 液晶組成物及び液晶素子
TWI349666B (en) * 2004-03-12 2011-10-01 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivatives
UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну

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