AR049184A1 - Procedimiento para la preparacion de derivados de 1, 4 - difenilazetidinona en presencia de agentes de sililacion y de un catalizador de ciclacion - Google Patents
Procedimiento para la preparacion de derivados de 1, 4 - difenilazetidinona en presencia de agentes de sililacion y de un catalizador de ciclacionInfo
- Publication number
- AR049184A1 AR049184A1 ARP050102099A ARP050102099A AR049184A1 AR 049184 A1 AR049184 A1 AR 049184A1 AR P050102099 A ARP050102099 A AR P050102099A AR P050102099 A ARP050102099 A AR P050102099A AR 049184 A1 AR049184 A1 AR 049184A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- coo
- substituted
- catalyst
- Prior art date
Links
- 239000003054 catalyst Substances 0.000 title abstract 6
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 230000001351 cycling effect Effects 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 23
- -1 alkyl- (C1-15) Chemical group 0.000 abstract 6
- 150000001450 anions Chemical class 0.000 abstract 4
- 150000001768 cations Chemical class 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 150000005840 aryl radicals Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- SJSSFUMSAFMFNM-NSHDSACASA-N (2s)-5-(diaminomethylideneamino)-2-(phenylmethoxycarbonylamino)pentanoic acid Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 SJSSFUMSAFMFNM-NSHDSACASA-N 0.000 abstract 1
- HZVHFGGPXITZGN-UHFFFAOYSA-N 1,4-diphenylazetidin-2-one Chemical class O=C1CC(C=2C=CC=CC=2)N1C1=CC=CC=C1 HZVHFGGPXITZGN-UHFFFAOYSA-N 0.000 abstract 1
- FRZNJFWQVYAVCE-UHFFFAOYSA-N 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)NC=2C=CC(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 FRZNJFWQVYAVCE-UHFFFAOYSA-N 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical class NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 229910000108 silver(I,III) oxide Inorganic materials 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE200410025071 DE102004025071B4 (de) | 2004-05-21 | 2004-05-21 | Verfahren zur Herstellung von Diphenylazetidinon-Derivaten |
| DE102005010770A DE102005010770A1 (de) | 2005-03-09 | 2005-03-09 | Verfahren zur Herstellung von 1,4-Diphenylazetidinon-Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049184A1 true AR049184A1 (es) | 2006-07-05 |
Family
ID=37561403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102099A AR049184A1 (es) | 2004-05-21 | 2005-05-20 | Procedimiento para la preparacion de derivados de 1, 4 - difenilazetidinona en presencia de agentes de sililacion y de un catalizador de ciclacion |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7488818B2 (https=) |
| EP (1) | EP1756049B1 (https=) |
| JP (1) | JP2007538042A (https=) |
| KR (1) | KR20070027554A (https=) |
| AR (1) | AR049184A1 (https=) |
| AT (1) | ATE376997T1 (https=) |
| AU (1) | AU2005245124A1 (https=) |
| BR (1) | BRPI0510150A (https=) |
| CA (1) | CA2567149A1 (https=) |
| CY (1) | CY1107425T1 (https=) |
| DE (1) | DE502005001841D1 (https=) |
| DK (1) | DK1756049T3 (https=) |
| ES (1) | ES2294712T3 (https=) |
| HR (1) | HRP20070570T3 (https=) |
| IL (1) | IL178991A0 (https=) |
| MA (1) | MA28635B1 (https=) |
| MX (1) | MXPA06013456A (https=) |
| NZ (1) | NZ551413A (https=) |
| PL (1) | PL1756049T3 (https=) |
| PT (1) | PT1756049E (https=) |
| RS (1) | RS50539B (https=) |
| RU (1) | RU2380361C2 (https=) |
| TW (1) | TW200611896A (https=) |
| UY (1) | UY28912A1 (https=) |
| WO (1) | WO2005113496A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| CN100471835C (zh) * | 2003-12-23 | 2009-03-25 | 默克公司 | 抗高胆固醇血症化合物 |
| EP1699759B1 (en) | 2003-12-23 | 2010-10-20 | AstraZeneca AB | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
| UY29607A1 (es) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
| MY148538A (en) | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| US20090047716A1 (en) * | 2007-06-07 | 2009-02-19 | Nurit Perlman | Reduction processes for the preparation of ezetimibe |
| EP2414529A2 (en) | 2009-04-01 | 2012-02-08 | Matrix Laboratories Ltd | Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe |
| WO2011056895A1 (en) * | 2009-11-03 | 2011-05-12 | University Of Notre Dame Du Lac | Ionic liquids comprising heteraromatic anions |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9670237B2 (en) | 2011-09-22 | 2017-06-06 | Ut-Battelle, Llc | Phosphonium-based ionic liquids and their use in the capture of polluting gases |
| WO2015048765A1 (en) | 2013-09-30 | 2015-04-02 | University Of Notre Dame Du Lac | Compounds, complexes, compositions, methods and systems for heating and cooling |
| US10086331B2 (en) | 2013-11-05 | 2018-10-02 | University Of Notre Dame Du Lac | Carbon dioxide capture using phase change ionic liquids |
| JP6803138B2 (ja) * | 2014-10-22 | 2020-12-23 | 三星エスディアイ株式会社Samsung SDI Co., Ltd. | ホスホニウム系化合物、それを含むエポキシ樹脂組成物、およびそれを用いて製造された半導体装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2107548T3 (es) * | 1991-07-23 | 1997-12-01 | Schering Corp | Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion. |
| FI960095L (fi) * | 1993-07-09 | 1996-01-09 | Schering Corp | Menetelmä atsetidinonien syntetitoimiseksi |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| HRP20030498A2 (en) * | 2000-12-21 | 2005-04-30 | Aventis Pharma Deutschland Gmbh | Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism |
| TWI291957B (en) * | 2001-02-23 | 2008-01-01 | Kotobuki Pharmaceutical Co Ltd | Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same |
-
2005
- 2005-05-20 TW TW094116483A patent/TW200611896A/zh unknown
- 2005-05-20 CA CA002567149A patent/CA2567149A1/en not_active Abandoned
- 2005-05-20 DE DE502005001841T patent/DE502005001841D1/de not_active Expired - Lifetime
- 2005-05-20 AT AT05747892T patent/ATE376997T1/de not_active IP Right Cessation
- 2005-05-20 AR ARP050102099A patent/AR049184A1/es not_active Application Discontinuation
- 2005-05-20 PT PT05747892T patent/PT1756049E/pt unknown
- 2005-05-20 RU RU2006145444/04A patent/RU2380361C2/ru not_active IP Right Cessation
- 2005-05-20 JP JP2007517094A patent/JP2007538042A/ja not_active Abandoned
- 2005-05-20 PL PL05747892T patent/PL1756049T3/pl unknown
- 2005-05-20 HR HR20070570T patent/HRP20070570T3/xx unknown
- 2005-05-20 ES ES05747892T patent/ES2294712T3/es not_active Expired - Lifetime
- 2005-05-20 MX MXPA06013456A patent/MXPA06013456A/es active IP Right Grant
- 2005-05-20 EP EP05747892A patent/EP1756049B1/de not_active Expired - Lifetime
- 2005-05-20 AU AU2005245124A patent/AU2005245124A1/en not_active Abandoned
- 2005-05-20 DK DK05747892T patent/DK1756049T3/da active
- 2005-05-20 UY UY28912A patent/UY28912A1/es unknown
- 2005-05-20 RS RSP-2007/0483A patent/RS50539B/sr unknown
- 2005-05-20 NZ NZ551413A patent/NZ551413A/en unknown
- 2005-05-20 KR KR1020067024431A patent/KR20070027554A/ko not_active Withdrawn
- 2005-05-20 BR BRPI0510150-6A patent/BRPI0510150A/pt not_active IP Right Cessation
- 2005-05-20 WO PCT/EP2005/005498 patent/WO2005113496A1/de not_active Ceased
-
2006
- 2006-11-01 IL IL178991A patent/IL178991A0/en unknown
- 2006-11-17 MA MA29462A patent/MA28635B1/fr unknown
- 2006-11-20 US US11/561,626 patent/US7488818B2/en not_active Expired - Fee Related
-
2008
- 2008-01-10 CY CY20081100037T patent/CY1107425T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE502005001841D1 (de) | 2007-12-13 |
| EP1756049A1 (de) | 2007-02-28 |
| KR20070027554A (ko) | 2007-03-09 |
| BRPI0510150A (pt) | 2007-10-02 |
| US20070149776A1 (en) | 2007-06-28 |
| TW200611896A (en) | 2006-04-16 |
| IL178991A0 (en) | 2007-03-08 |
| NZ551413A (en) | 2009-07-31 |
| MA28635B1 (fr) | 2007-06-01 |
| PT1756049E (pt) | 2007-12-17 |
| MXPA06013456A (es) | 2007-03-01 |
| WO2005113496A1 (de) | 2005-12-01 |
| US7488818B2 (en) | 2009-02-10 |
| JP2007538042A (ja) | 2007-12-27 |
| PL1756049T3 (pl) | 2008-02-29 |
| RU2380361C2 (ru) | 2010-01-27 |
| CA2567149A1 (en) | 2005-12-01 |
| CY1107425T1 (el) | 2013-03-13 |
| RS50539B (sr) | 2010-05-07 |
| AU2005245124A1 (en) | 2005-12-01 |
| RU2006145444A (ru) | 2008-06-27 |
| ES2294712T3 (es) | 2008-04-01 |
| EP1756049B1 (de) | 2007-10-31 |
| DK1756049T3 (da) | 2008-02-25 |
| HRP20070570T3 (en) | 2008-01-31 |
| ATE376997T1 (de) | 2007-11-15 |
| UY28912A1 (es) | 2005-12-30 |
| HK1103296A1 (zh) | 2007-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |