AR048310A1 - Uso de derivados de 5-amino-pirimidinas en la preparacion de parasiticidas - Google Patents
Uso de derivados de 5-amino-pirimidinas en la preparacion de parasiticidasInfo
- Publication number
- AR048310A1 AR048310A1 ARP050100845A ARP050100845A AR048310A1 AR 048310 A1 AR048310 A1 AR 048310A1 AR P050100845 A ARP050100845 A AR P050100845A AR P050100845 A ARP050100845 A AR P050100845A AR 048310 A1 AR048310 A1 AR 048310A1
- Authority
- AR
- Argentina
- Prior art keywords
- haloalkenyl
- alkylsulfinyl
- alkyl
- alkenylsulfonyl
- alkylsulfonyl
- Prior art date
Links
- 150000005008 5-aminopyrimidines Chemical class 0.000 title abstract 2
- 239000002297 parasiticide Substances 0.000 title abstract 2
- -1 CONR2R3 Chemical group 0.000 abstract 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 7
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 6
- 125000005137 alkenylsulfonyl group Chemical group 0.000 abstract 6
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 5
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 abstract 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 5
- 229910006069 SO3H Inorganic materials 0.000 abstract 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 4
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 4
- 125000004749 (C1-C6) haloalkylsulfinyl group Chemical group 0.000 abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 abstract 4
- 125000005108 alkenylthio group Chemical group 0.000 abstract 4
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
- 125000005366 cycloalkylthio group Chemical group 0.000 abstract 4
- 125000005280 halo alkyl sulfonyloxy group Chemical group 0.000 abstract 4
- 125000005291 haloalkenyloxy group Chemical group 0.000 abstract 4
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 4
- 125000005347 halocycloalkyl group Chemical group 0.000 abstract 4
- 125000005136 alkenylsulfinyl group Chemical group 0.000 abstract 3
- 125000004997 halocarbonyl group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 125000005109 alkynylthio group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 244000078703 ectoparasite Species 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000004692 haloalkylcarbonyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 125000004993 haloalkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 abstract 1
- 125000004664 haloalkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 230000000590 parasiticidal effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Catching Or Destruction (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente trata del uso de los derivados de 5-amino-pirimidinas en la preparacion de parasiticidas, y los enantiomeros e isomeros geométricos de los mismos, para controlar parásitos en animales de sangre caliente. Reivindicacion 1: El uso de un compuesto de la formula (1) en donde: R1 es H, halogeno, ciano, OH, SH, NO2, COOH, COOR2, CONH2, CONR2R3, SO3H, SO2NR2R3, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquenilo C2-6, haloalquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, halocicloalquilo C3-6, cicloalquiloxi C3-6, cicloalquiltio C3-6, alqueniloxi C2-6, haloalqueniloxi C2-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfoniloxi C1-6, haloalquilsulfoniloxi C1-6, alquilsulfinilo C1-6, halo-alquilsulfinilo C1-6, alquilsulfonilo C1-6 haloalquilsulfonilo C1-6, alqueniltio C2-6, halo-alqueniltio C2-6, alquenilsulfinilo C2-6, halo-alquenilsulfinilo C2-6, alquenilsulfonilo C2-6, haloalquenilsulfonilo C2-6, NR2R3, arilo no substituido o substituido de 1 a 5 veces o hetarilo no substituido o substituido, los sustituyentes seleccionados del grupo que consiste de halogeno, ciano, OH, SH, NO2, COOH, COOR2, CONH2, CONR2R3, SO3H, SO2NR2R3, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquenilo C2- 6, haloalquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, halocicloalquilo C3-6, cicloalquiloxi C3-6, cicloalquiltio C3-6, alqueniloxi C2-6, haloalqueniloxi C2-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfoniloxi C1-6, haloalquilsulfoniloxi C1- 6, alquilsulfinilo C1-6, halo-alquilsulfinilo C1-6, alquilsulfonilo C1-6 haloalquilsulfinilo C1-6, alqueniltio C2-6, haloalqueniltio C2-6, alquenilsulfinilo C2-6, haloalquenilsulfinilo C2-6, alquenilsulfonilo C2-6, haloalquenilsulfinilo C2-6, y NR2R3, R2 y R3, independientemente uno de otro, significan H, alquilo C1-6, haloalquilo C1-6, formilo, alquilcarbonilo C1-6, haloalquilcarbonilo C1-6, alcoxicarbonilo C1-6, haloalcoxicarbonilo C1-6, alquilaminocarbonilo C1-6, di-alquilaminocarbonilo C1-6 o bencilo no substituido o substituido de 1 a 5 veces, los sustituyentes seleccionados del grupo que consiste de halogeno, ciano, OH, SH, NO2, COOH, COOR2, CONH2, CONR2R3, SO3H, SO2NR2R3, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquenilo C2-6, haloalquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, halocicloalquilo C3-6, cicloalquiloxi C3-6, cicloalquiltio C3-6, alqueniloxi C2-6, haloalqueniloxi C2-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfoniloxi C1-6, haloalquilsulfoniloxi C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, alqueniltio C2-6, haloalqueniltio C2-6, alquenilsulfinilo C2-6, haloalquenilsulfinilo C2-6, alquenilsulfonilo C2-6, y haloalquenilsulfonilo C2-6; R4, R5, R6, R7, R8, R9, R10, R11, R12 y R13, independientemente uno del otro, son H, halogeno, ciano, nitro, OH, SH, NO2, COOH, COOR2, CONH2, CONR2R3, SO3H, SO2NR2R3, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquenilo C2-6, haloalquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alqueniloxi C2-6, haloalqueniloxi C2-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfoniloxi C1-6, haloalquilsulfoniloxi C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfinilo C2-6, alqueniltio C2-6, haloalqueniltio C2-6, alquenilsulfonilo C2-6, haloalquenilsulfinilo C2-6, alquenilsulfonilo C2-6, haloalquenilsulfonilo C2-6, alquilamino C1-6, dialquilamino C1-6, alquilsulfonilamino C1-6, haloalquilsulfonilamino C1-6, alquilcarbonilo C1-6, haloalquilcarbonilo C1-6, alcoxicarbonilo C1-6, alquilcarbonilo C1-6, dialquilaminocarbonilo C1-6, arilo no substituido o substituido de 1 a 5 veces o hetarilo no substituido o substituido, los sustituyentes seleccionados del grupo que consiste de halogeno, ciano, OH, SH, NO2, COOH, COOR2, CONH2, CONR2R3, SO3H, SO2NR2R3, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquenilo C2-6, haloalquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, halocicloalquilo C3-6, cicloalquiloxi C3-6, cicloalquiltio C3-6, alqueniloxi C2-6, haloalqueniloxi C2-6, alquiltio C1-6, haloalquiltio C1-6, alquilsulfoniloxi C1-6, haloalquilsulfoniloxi C1-6, alquilsulfinilo C1-6, haloalquilsulfinilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, alqueniltio C2-6, haloalqueniltio C2-6, alquenilsulfinilo C2-6, haloalquenilsulfinilo C2-6, alquenilsulfonilo C2-6, haloalquenilsulfonilo C2-6 y NR2R3; X1 y X2, independientemente uno del otro, son C(R14)(R15), NR14, O, S, SO o SO2; y R14 y R15, independientemente uno del otro, significan H, alquilo C1-6, formilo, alquilcarbonilo C1-6, o haloalquilcarbonilo C1-6; en el control de ectoparásitos en animales. Reivindicacion 26: El compuesto de la formula (1) como se define en cualquiera de las reivindicaciones 1 a 21 para el uso en el tratamiento de ectoparásitos en animales no seres humanos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04005423A EP1574502A1 (en) | 2004-03-08 | 2004-03-08 | Use of pyrimidine compounds in the preparation of parasiticides |
Publications (1)
Publication Number | Publication Date |
---|---|
AR048310A1 true AR048310A1 (es) | 2006-04-19 |
Family
ID=34814254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050100845A AR048310A1 (es) | 2004-03-08 | 2005-03-04 | Uso de derivados de 5-amino-pirimidinas en la preparacion de parasiticidas |
Country Status (13)
Country | Link |
---|---|
US (2) | US20070155757A1 (es) |
EP (2) | EP1574502A1 (es) |
JP (1) | JP4598052B2 (es) |
CN (1) | CN1930134B (es) |
AR (1) | AR048310A1 (es) |
AU (1) | AU2005219559B2 (es) |
BR (1) | BRPI0508588A (es) |
CA (1) | CA2557749A1 (es) |
NZ (1) | NZ549426A (es) |
RU (1) | RU2379296C2 (es) |
TW (1) | TWI349665B (es) |
WO (1) | WO2005085211A1 (es) |
ZA (1) | ZA200607045B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
KR20070083484A (ko) | 2004-07-14 | 2007-08-24 | 피티씨 테라퓨틱스, 인크. | C형 간염 치료 방법 |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
CN101495462B (zh) | 2006-07-21 | 2012-03-21 | 诺瓦提斯公司 | 嘧啶衍生物及其作为杀虫剂的用途 |
US8222403B2 (en) * | 2009-11-12 | 2012-07-17 | The United States Of America, As Represented By The Secretary Of The Navy | Heteroaromatic phthalonitriles |
WO2012000922A2 (en) | 2010-06-28 | 2012-01-05 | Novartis Ag | New Use |
JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
EP3024049B1 (en) * | 2014-11-18 | 2021-08-25 | Heraeus Deutschland GmbH & Co. KG | Fluorinated aromatic small molecules as functional additives for dispersion of conductive polymers |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL106324A (en) * | 1992-07-17 | 1998-09-24 | Shell Int Research | Transformed pyrimidine compounds, their preparation and use as pesticides |
US6998131B2 (en) * | 1996-09-19 | 2006-02-14 | Merial Limited | Spot-on formulations for combating parasites |
WO1998054154A1 (fr) * | 1997-05-28 | 1998-12-03 | Nippon Soda Co., Ltd. | Composes de pyrimidine, leur procede de production et pesticides |
US6342499B1 (en) * | 1998-07-14 | 2002-01-29 | Basf Aktiengesellschaft | Parasitic and saprophagous mite control in beneficial insects |
AU3357700A (en) | 1999-02-16 | 2000-09-04 | E.I. Du Pont De Nemours And Company | Phenoxypyrimidine insecticides and acaricides |
ATE283844T1 (de) | 2000-09-19 | 2004-12-15 | Sumitomo Chemical Co | Pyrimidinverbindungen und deren verwendung als pestizide |
-
2004
- 2004-03-08 EP EP04005423A patent/EP1574502A1/en not_active Withdrawn
-
2005
- 2005-03-04 AR ARP050100845A patent/AR048310A1/es not_active Application Discontinuation
- 2005-03-07 EP EP05715800A patent/EP1725539A1/en not_active Withdrawn
- 2005-03-07 NZ NZ549426A patent/NZ549426A/en unknown
- 2005-03-07 WO PCT/EP2005/002391 patent/WO2005085211A1/en active Application Filing
- 2005-03-07 AU AU2005219559A patent/AU2005219559B2/en not_active Ceased
- 2005-03-07 CA CA002557749A patent/CA2557749A1/en not_active Abandoned
- 2005-03-07 TW TW094106802A patent/TWI349665B/zh not_active IP Right Cessation
- 2005-03-07 JP JP2007502255A patent/JP4598052B2/ja not_active Expired - Fee Related
- 2005-03-07 RU RU2006135545/04A patent/RU2379296C2/ru not_active IP Right Cessation
- 2005-03-07 CN CN2005800075045A patent/CN1930134B/zh not_active Expired - Fee Related
- 2005-03-07 BR BRPI0508588-8A patent/BRPI0508588A/pt not_active IP Right Cessation
- 2005-03-07 US US10/591,624 patent/US20070155757A1/en not_active Abandoned
-
2006
- 2006-08-23 ZA ZA200607045A patent/ZA200607045B/xx unknown
-
2009
- 2009-02-27 US US12/394,112 patent/US20090197902A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0508588A (pt) | 2007-08-21 |
EP1574502A1 (en) | 2005-09-14 |
ZA200607045B (en) | 2008-04-30 |
US20070155757A1 (en) | 2007-07-05 |
NZ549426A (en) | 2010-06-25 |
RU2379296C2 (ru) | 2010-01-20 |
TW200609224A (en) | 2006-03-16 |
CA2557749A1 (en) | 2005-09-15 |
CN1930134A (zh) | 2007-03-14 |
JP4598052B2 (ja) | 2010-12-15 |
JP2007528376A (ja) | 2007-10-11 |
AU2005219559A1 (en) | 2005-09-15 |
EP1725539A1 (en) | 2006-11-29 |
TWI349665B (en) | 2011-10-01 |
WO2005085211A1 (en) | 2005-09-15 |
AU2005219559B2 (en) | 2009-03-12 |
RU2006135545A (ru) | 2008-04-20 |
US20090197902A1 (en) | 2009-08-06 |
CN1930134B (zh) | 2010-06-16 |
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