AR048081A1 - Proceso para preparar intermediarios de cefalosporinas mediante esteres de acido alfa-yodo-1-azetidinacetico y trialquilfosfitos. - Google Patents
Proceso para preparar intermediarios de cefalosporinas mediante esteres de acido alfa-yodo-1-azetidinacetico y trialquilfosfitos.Info
- Publication number
- AR048081A1 AR048081A1 ARP050100859A ARP050100859A AR048081A1 AR 048081 A1 AR048081 A1 AR 048081A1 AR P050100859 A ARP050100859 A AR P050100859A AR P050100859 A ARP050100859 A AR P050100859A AR 048081 A1 AR048081 A1 AR 048081A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- benzyl
- nitrobenzyl
- para
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Un proceso para preparar un compuesto de la formula (1), en la que R1 es para-nitrobencilo o alilo y R2 es bencilo o bencilo sustituido; que comprende el paso de hacer reaccionar un compuesto de la formula (2), en la que R1 y R2 son como se definieron con anterioridad; con una sal de yoduro para producir el compuesto de la formula (1). Reivindicacion 2: Un proceso para preparar un compuesto de la formula (3), en la que R1 para-nitrobencilo o alilo; R2 es bencilo o bencilo sustituido; y R3 es alquilo C1-6; que comprende el paso de reaccionar un compuesto de la formula (1), como se describe en la reivindicacion 1, con P(OR3)3 en un solvente. Reivindicacion 4: El proceso de acuerdo con la reivindicacion 2, que además comprende los pasos de: a) calentar dicho compuesto de la formula (3) en un solvente en presencia de LiCl y una base orgánica soluble para formar un compuesto de la formula (4), en la que R1 para-nitrobencilo o alilo; y R2 es bencilo o bencilo sustituido; y b) hacer reaccionar el compuesto de la formula (4) con R4-OH y PX5 para producir los compuestos de la formula (5) en la que R1 es como se definio con anterioridad y R4 es alquilo C1-6 y X es halo. Reivindicacion 13: Un compuesto de la formula (6), en la que R1 es para-nitrobencilo; R2 es bencilo; en donde * representa un centro quiral que representa una configuracion absoluta de (R) o (S); en donde dicho compuesto contiene isomeros (R) y (S) en una proporcion entre 0:1 y 1:0.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55184504P | 2004-03-09 | 2004-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048081A1 true AR048081A1 (es) | 2006-03-29 |
Family
ID=34960709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100859A AR048081A1 (es) | 2004-03-09 | 2005-03-07 | Proceso para preparar intermediarios de cefalosporinas mediante esteres de acido alfa-yodo-1-azetidinacetico y trialquilfosfitos. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20070208172A1 (es) |
| EP (1) | EP1725568A1 (es) |
| JP (1) | JP2007528386A (es) |
| CN (1) | CN1930173A (es) |
| AR (1) | AR048081A1 (es) |
| AU (1) | AU2005225626B2 (es) |
| BR (1) | BRPI0508595A (es) |
| CA (1) | CA2557798A1 (es) |
| CO (1) | CO5721009A2 (es) |
| IL (1) | IL177297A0 (es) |
| NO (1) | NO20064580L (es) |
| RU (1) | RU2321590C1 (es) |
| WO (1) | WO2005092900A1 (es) |
| ZA (1) | ZA200606742B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2575261B (en) | 2018-07-02 | 2022-03-09 | Norbrook Lab Ltd | Intermediates in the synthesis of C3-substituted cephalosporins |
| CN117186116B (zh) * | 2023-09-07 | 2024-06-07 | 浙江荣耀生物科技股份有限公司 | 一种头孢维星中间体的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001997A (en) * | 1990-07-24 | 1999-12-14 | Bateson; John Hargreaves | Cephalosporins and homologues, preparations and pharmaceutical compositions |
| GB2300856A (en) * | 1995-05-16 | 1996-11-20 | Pfizer Ltd | Beta-lactam preparation |
| DE19704841A1 (de) * | 1997-02-08 | 1998-08-13 | Itt Mfg Enterprises Inc | Verfahren und Vorrichtung zur Regelung der Längsdynamik eines Fahrzeugs |
| US6208106B1 (en) * | 1999-12-22 | 2001-03-27 | Visteon Global Technologies, Inc. | Method and system for adjusting headway in an adaptive speed control system based on road surface coefficient of friction |
| GB0019124D0 (en) * | 2000-08-03 | 2000-09-27 | Pfizer | Novel process |
| US6304808B1 (en) * | 2000-09-09 | 2001-10-16 | Kelsey-Hayes Company | Enhanced active brake control system functionality through system integration with adaptive cruise control |
| WO2002046199A1 (en) * | 2000-12-04 | 2002-06-13 | Pfizer Products Inc. | Process and ester derivatives useful for preparation of cephalosporins |
| AU2394302A (en) * | 2000-12-04 | 2002-06-18 | Pfizer Prod Inc | Coupling process and intermediates useful for preparing cephalosphorins |
-
2005
- 2005-02-25 EP EP05708621A patent/EP1725568A1/en not_active Withdrawn
- 2005-02-25 WO PCT/IB2005/000508 patent/WO2005092900A1/en active Search and Examination
- 2005-02-25 BR BRPI0508595-0A patent/BRPI0508595A/pt not_active IP Right Cessation
- 2005-02-25 CN CNA2005800075596A patent/CN1930173A/zh active Pending
- 2005-02-25 JP JP2007502426A patent/JP2007528386A/ja not_active Abandoned
- 2005-02-25 CA CA002557798A patent/CA2557798A1/en not_active Abandoned
- 2005-02-25 US US10/592,201 patent/US20070208172A1/en not_active Abandoned
- 2005-02-25 AU AU2005225626A patent/AU2005225626B2/en not_active Ceased
- 2005-02-25 RU RU2006132232/04A patent/RU2321590C1/ru not_active IP Right Cessation
- 2005-03-07 AR ARP050100859A patent/AR048081A1/es unknown
-
2006
- 2006-08-03 IL IL177297A patent/IL177297A0/en unknown
- 2006-08-14 ZA ZA200606742A patent/ZA200606742B/xx unknown
- 2006-09-08 CO CO06090501A patent/CO5721009A2/es not_active Application Discontinuation
- 2006-10-09 NO NO20064580A patent/NO20064580L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20064580L (no) | 2006-10-09 |
| WO2005092900A1 (en) | 2005-10-06 |
| CN1930173A (zh) | 2007-03-14 |
| BRPI0508595A (pt) | 2007-08-21 |
| ZA200606742B (en) | 2008-09-25 |
| RU2321590C1 (ru) | 2008-04-10 |
| AU2005225626A1 (en) | 2005-10-06 |
| US20070208172A1 (en) | 2007-09-06 |
| JP2007528386A (ja) | 2007-10-11 |
| IL177297A0 (en) | 2006-12-10 |
| AU2005225626B2 (en) | 2008-03-13 |
| EP1725568A1 (en) | 2006-11-29 |
| CO5721009A2 (es) | 2007-01-31 |
| CA2557798A1 (en) | 2005-10-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2396268C2 (ru) | Ацетамидные соединения в качестве фунгицидов | |
| BRPI0415855A (pt) | processo para preparação de ésteres de ácido 2-dihalogenacil-3-amino-acrìlico e ésteres de ácido 3-dihalogeno-metil-pirazol-4-carboxìlico | |
| RU2009105669A (ru) | Способ получения 3-замещенных 2-амино-5-галогенбензамидов | |
| AR057022A1 (es) | Proceso para resolver un r o s acido mandelico a partir de su mezcla racemica | |
| EA201490831A1 (ru) | Способ получения хинолиновых производных | |
| ATE533775T1 (de) | Verfahren zur herstellung von 17-vinyl-triflaten als intermediate | |
| AR049374A1 (es) | Sintesis de compuestos de ester y acido borico | |
| CO6321190A2 (es) | Compuestos mesoionicos de pirimidinio para el control de plagas de invertebrados | |
| RS51341B (en) | INTERMEDIATE COMPOUNDS FOR THE TRANS-5-CHLOR-2-METHYL-2,3A, 12B-TETRAHYDRO-1H-DIBENZE [2,3; 6,7] OXEPINO [4,5-C] Pyrrole | |
| HRP20080510T3 (en) | Process for the preparation of optically active derivatives of 2-(2-pyridylmethylsulfinyl)-benzimidazole via inclusion complex with 1,1'-binaphthalene-2, 2'diol | |
| EA200701470A1 (ru) | Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений | |
| DK1877384T3 (da) | Fremgangsmåde til fremstilling af eventuelt 2-substituerede 1,6-dihydro-6-oxo-4-pyrimidincarboxylsyrer | |
| EA201891437A1 (ru) | Способ разделения энантиомеров пиперазиновых производных | |
| ATE441627T1 (de) | Verfahren zur herstellung von valsartan | |
| EA200701738A1 (ru) | Способ получения транс-1-((1r,3s)-6-хлор-3-фенилиндан-1-ил)-3,3-диметилпиперазина | |
| BR112015001769A2 (pt) | Processo para a síntese de compostos de ureia substituída | |
| AR048081A1 (es) | Proceso para preparar intermediarios de cefalosporinas mediante esteres de acido alfa-yodo-1-azetidinacetico y trialquilfosfitos. | |
| BRPI0507422A (pt) | processo para produção de ácido 2,5-dimetilfenilacético | |
| RU2014129937A (ru) | Способы и промежуточные соединения для получения фармацевтических агентов | |
| EA201490998A1 (ru) | Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)-уксусной кислоты | |
| AR043825A1 (es) | Procesos de preparacion de 5-(haloacetil)-8-(oxisustituidos)-(1h)-quinolin-2-onas | |
| AR051936A1 (es) | Proceso para la preparacion de pirazoles | |
| ATE370736T1 (de) | Verfahren zur herstellung eines piperazinderivates | |
| AR075441A1 (es) | Un proceso para la preparacion de etoricoxib | |
| DE60203944D1 (de) | Verbesserte herstellung von ceftiofur zwischenprodkten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |