AR046586A1 - Tratamientos de trastornos bipolares y sintomas asociados - Google Patents
Tratamientos de trastornos bipolares y sintomas asociadosInfo
- Publication number
- AR046586A1 AR046586A1 ARP040101701A ARP040101701A AR046586A1 AR 046586 A1 AR046586 A1 AR 046586A1 AR P040101701 A ARP040101701 A AR P040101701A AR P040101701 A ARP040101701 A AR P040101701A AR 046586 A1 AR046586 A1 AR 046586A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- fluoro
- treatment
- bipolar disorder
- mammal
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 8
- 208000020925 Bipolar disease Diseases 0.000 title abstract 6
- -1 benzoisothiazolyl Chemical group 0.000 abstract 13
- 125000001153 fluoro group Chemical group F* 0.000 abstract 5
- 241000124008 Mammalia Species 0.000 abstract 4
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 2
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 abstract 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001041 indolyl group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000005493 quinolyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005874 benzothiadiazolyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 230000036651 mood Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 abstract 1
- 229960000607 ziprasidone Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Procedimiento para los tratamientos relativos a trastorno bipolar en un mamífero, incluyendo un ser humano, incluyéndose entre los tratamientos, el tratamiento de trastorno bipolar de ciclo rápido, tratamiento de síntomas de trastorno bipolar, seleccionados entre el grupo constituido por manía aguda y depresión; tratamiento para efectuar estabilización de estado de ánimo; tratamiento para prevenir la recaída en episodios bipolares, y para el tratamiento de pensamientos y tendencias suicidas asociadas a trastorno bipolar, comprendiendo la administración a dicho mamífero de una cantidad eficaz de ziprasidona ó de un compuesto de fórmula (1), o una sal de adición de ácido farmacéuticamente aceptable del mismo, en la que Ar, n, X e Y son como se han definido. Reivindicación 1: Un procedimiento de tratar trastorno bipolar de ciclo rápido en un mamífero en necesidad del mismo que comprende la administración a dicho mamífero de una cantidad farmacéuticamente eficaz de un compuesto de fórmula (1), o una sal de adición de ácido farmacéuticamente aceptable del mismo, en la que Ar es benzoisotiazolilo o un óxido o dióxido del mismo cada uno opcionalmente sustituido con un fluoro, cloro, trifluorometilo, metoxi, ciano, nitro o naftilo opcionalmente sustituido con fluoro, cloro, trifluorometilo, metoxi, ciano, o nitro; quinolilo; 6-hidroxi-8-quinolilo; isoquinolilo, quinazolilo; benzotiazolilo; benzotiadiazolilo; benzotriazolilo; benzoxazolilo; benzoxazolonilo; indolilo; indanilo opcionalmente sustituido con uno a dos fluoro, 3-indazolilo opcionalmente sustituido con 1-trifluorometilfenilo; o ftalazinilo; n es 1 ó 2; y X e Y junto con el fenilo al que están unidos forman quinolilo; 2-hidroxiquinolilo, benzotiazolilo; 2-aminobenzotiazolilo; benzoisotiazolilo; indazolilo; 2-hidroxiindazolilo; indolilo; espiro; oxindolilo opcionalmente sustituido con uno a tres de alquilo (C1-3), o uno de cloro, fluoro o fenilo, dicho fenilo opcionalmente sustituido con un cloro o fluoro; benzoxazolilo; 2-aminobenzoxazolilo; benzoxazolonilo; 2-aminobenzoxazolinilo; benzotiazolonilo; benzoimidazolonilo; o benzotriazolilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47145003P | 2003-05-16 | 2003-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046586A1 true AR046586A1 (es) | 2005-12-14 |
Family
ID=33452446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101701A AR046586A1 (es) | 2003-05-16 | 2004-05-17 | Tratamientos de trastornos bipolares y sintomas asociados |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050038036A1 (es) |
| EP (1) | EP1626723A1 (es) |
| JP (1) | JP2007516955A (es) |
| KR (1) | KR20060009938A (es) |
| CN (1) | CN1780626A (es) |
| AR (1) | AR046586A1 (es) |
| AU (1) | AU2004237961A1 (es) |
| BR (1) | BRPI0410222A (es) |
| CA (1) | CA2525326A1 (es) |
| MX (1) | MXPA05012320A (es) |
| TW (1) | TW200509929A (es) |
| WO (1) | WO2004100957A1 (es) |
| ZA (1) | ZA200508523B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1408976B3 (en) | 2001-07-20 | 2010-08-25 | Psychogenics Inc. | Treatment for attention-deficit hyperactivity disorder |
| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| AR056968A1 (es) * | 2005-04-11 | 2007-11-07 | Xenon Pharmaceuticals Inc | Compuestos espiro-oxindol y composiciones farmacéuticas |
| AR056317A1 (es) * | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| JP2009524637A (ja) * | 2006-01-27 | 2009-07-02 | ファイザー・プロダクツ・インク | アミノフタラジン誘導体化合物 |
| CN100491375C (zh) * | 2006-07-01 | 2009-05-27 | 浙江美诺华药物化学有限公司 | 一种齐拉西酮的制备方法 |
| MX2009003874A (es) * | 2006-10-12 | 2009-04-22 | Xenon Pharmaceuticals Inc | Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos. |
| MX2009003876A (es) * | 2006-10-12 | 2009-05-11 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos. |
| CA2666143A1 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| CA2741024A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| KR101286323B1 (ko) | 2008-10-17 | 2013-07-15 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물 및 치료제로서의 그의 용도 |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| MY165579A (en) | 2009-10-14 | 2018-04-05 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| WO2011047173A2 (en) * | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| CN105726531A (zh) | 2010-02-26 | 2016-07-06 | 泽农医药公司 | 用于局部给药的螺-羟吲哚化合物的药物组合物及其作为治疗剂的用途 |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| IL125951A (en) * | 1997-09-05 | 2003-09-17 | Pfizer Prod Inc | A pharmaceutical composition comprising a piperazinyl-heterocyclic compound for treating tourette's syndrome, obsessive compulsive disorder, chronic motor or vocal tic disorder in a mammal |
| IL127497A (en) * | 1997-12-18 | 2002-07-25 | Pfizer Prod Inc | Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders |
| US6387904B2 (en) * | 1998-05-18 | 2002-05-14 | Pfizer Inc | Method of treating glaucoma and ischemic retinopathy |
| EP0966967A3 (en) * | 1998-05-29 | 2000-05-31 | Eli Lilly And Company | Combination therapy of olanzapine (zyprexa) and fluoxetine (prozac) for treatment of bipolar disorder |
-
2004
- 2004-05-12 CA CA002525326A patent/CA2525326A1/en not_active Abandoned
- 2004-05-12 EP EP04732360A patent/EP1626723A1/en not_active Withdrawn
- 2004-05-12 BR BRPI0410222-3A patent/BRPI0410222A/pt not_active IP Right Cessation
- 2004-05-12 US US10/843,915 patent/US20050038036A1/en not_active Abandoned
- 2004-05-12 MX MXPA05012320A patent/MXPA05012320A/es unknown
- 2004-05-12 JP JP2006530661A patent/JP2007516955A/ja active Pending
- 2004-05-12 KR KR1020057021793A patent/KR20060009938A/ko not_active Application Discontinuation
- 2004-05-12 WO PCT/IB2004/001601 patent/WO2004100957A1/en active Application Filing
- 2004-05-12 CN CNA2004800112618A patent/CN1780626A/zh active Pending
- 2004-05-12 AU AU2004237961A patent/AU2004237961A1/en not_active Abandoned
- 2004-05-14 TW TW093113690A patent/TW200509929A/zh unknown
- 2004-05-17 AR ARP040101701A patent/AR046586A1/es not_active Application Discontinuation
-
2005
- 2005-10-02 ZA ZA200508523A patent/ZA200508523B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2525326A1 (en) | 2004-11-25 |
| ZA200508523B (en) | 2007-04-25 |
| MXPA05012320A (es) | 2006-01-30 |
| JP2007516955A (ja) | 2007-06-28 |
| AU2004237961A1 (en) | 2004-11-25 |
| CN1780626A (zh) | 2006-05-31 |
| WO2004100957A1 (en) | 2004-11-25 |
| EP1626723A1 (en) | 2006-02-22 |
| US20050038036A1 (en) | 2005-02-17 |
| TW200509929A (en) | 2005-03-16 |
| KR20060009938A (ko) | 2006-02-01 |
| BRPI0410222A (pt) | 2006-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |