AR045625A1 - Sintesis de 4-amino-5-cloro-2-metoxi-n-(1-azabiciclo [3.3.1]non-4-il)benzamida - Google Patents
Sintesis de 4-amino-5-cloro-2-metoxi-n-(1-azabiciclo [3.3.1]non-4-il)benzamidaInfo
- Publication number
- AR045625A1 AR045625A1 ARP040103240A ARP040103240A AR045625A1 AR 045625 A1 AR045625 A1 AR 045625A1 AR P040103240 A ARP040103240 A AR P040103240A AR P040103240 A ARP040103240 A AR P040103240A AR 045625 A1 AR045625 A1 AR 045625A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- chloro
- amino
- acid
- azabiciclo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
La presente se relaciona con un proceso mejorado para la producción de clorhidrato de [(-+)-endo]-4-amino-5-cloro-2-metoxi-N-(1-azabiciclo[3.3.1]non-4-il)benzamida, y sus intermediarios. Este compuesto es útil en el tratamiento de trastornos gástricos. Reivindicación 1 Un proceso para la preparación de compuesto de fórmula (1), que comprende a) preparar cloruro ácido de fórmula (2), a partir de ácido de fórmula (3), haciendo reaccionar el ácido (3) con cloruro de oxalilo o cloruro de tionilo, en diclorometano, tolueno, dimetilformamida (DMF) o tetrahidrofurano (THF); b) hacer reaccionar el cloruro ácido (2) en tolueno, con amina de fórmula (4) y aislar de allí el producto de fórmula (5).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0321091.1A GB0321091D0 (en) | 2003-09-09 | 2003-09-09 | Synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045625A1 true AR045625A1 (es) | 2005-11-02 |
Family
ID=29226752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103240A AR045625A1 (es) | 2003-09-09 | 2004-09-09 | Sintesis de 4-amino-5-cloro-2-metoxi-n-(1-azabiciclo [3.3.1]non-4-il)benzamida |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7189852B2 (es) |
| EP (1) | EP1664048A2 (es) |
| JP (1) | JP2007505089A (es) |
| KR (1) | KR20060092211A (es) |
| CN (1) | CN1849320A (es) |
| AR (1) | AR045625A1 (es) |
| AU (1) | AU2004270465A1 (es) |
| BR (1) | BRPI0414200A (es) |
| CA (1) | CA2537536A1 (es) |
| EA (1) | EA200600563A1 (es) |
| GB (1) | GB0321091D0 (es) |
| IL (1) | IL173736A0 (es) |
| MX (1) | MXPA06002743A (es) |
| NO (1) | NO20061575L (es) |
| TW (1) | TW200526661A (es) |
| WO (1) | WO2005023808A2 (es) |
| ZA (1) | ZA200601991B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080008933A1 (en) * | 2005-12-23 | 2008-01-10 | Boston-Power, Inc. | Lithium-ion secondary battery |
| US7811707B2 (en) * | 2004-12-28 | 2010-10-12 | Boston-Power, Inc. | Lithium-ion secondary battery |
| TWI426678B (zh) * | 2006-06-28 | 2014-02-11 | Boston Power Inc | 具有多重充電率之電子裝置、電池組、充電於電子裝置中的鋰離子電荷儲存電源供應器之方法及可攜式電腦 |
| US20090297937A1 (en) * | 2008-04-24 | 2009-12-03 | Lampe-Onnerud Christina M | Lithium-ion secondary battery |
| WO2010030875A1 (en) * | 2008-09-12 | 2010-03-18 | Boston-Power, Inc. | Method and apparatus for embedded battery cells and thermal management |
| WO2010135260A2 (en) * | 2009-05-18 | 2010-11-25 | Boston-Power, Inc. | Energy efficient and fast charge modes of a rechargeable battery |
| US20110049977A1 (en) * | 2009-09-01 | 2011-03-03 | Boston-Power, Inc. | Safety and performance optimized controls for large scale electric vehicle battery systems |
| EP2819212A1 (en) * | 2009-09-01 | 2014-12-31 | Boston-Power, Inc. | Large scale battery systems and method of assembly |
| CN111032699B (zh) | 2017-07-21 | 2022-08-02 | 罗门哈斯公司 | 聚(甲基丙烯酸甲酯)树脂组合物 |
| US20220298107A1 (en) * | 2019-08-29 | 2022-09-22 | Janssen Biotech, Inc. | Substituted urea dihydroorotate dehydrogenase inhibitors |
| CN112094239A (zh) * | 2020-11-03 | 2020-12-18 | 燃点(南京)生物医药科技有限公司 | 一种乌拉地尔杂质化合物、制备方法及其应用 |
| CN113773219B (zh) * | 2021-09-30 | 2024-08-13 | 内蒙古康普药业有限公司 | 一种甲氧氯普胺双氯杂质的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2119724B2 (de) | 1970-04-24 | 1976-04-29 | Teikoku Hormone Manufacturing Co. Ltd., Tokio | Verfahren zur herstellung einer halogensubstituierten benzoesaeure |
| JPS5010573B1 (es) * | 1970-04-24 | 1975-04-22 | ||
| AU563225B2 (en) * | 1982-04-14 | 1987-07-02 | Alizyme Therapeutics Limited | I-aza bicyclic compounds |
| US4612319A (en) * | 1982-04-14 | 1986-09-16 | Beecham Group P.L.C. | Bridged quinolizidinylbenzamides, compositions containing them and methods for their use |
| GB8523211D0 (en) * | 1985-09-19 | 1985-10-23 | Beecham Group Plc | Compounds |
| GB8607163D0 (en) | 1986-03-22 | 1986-04-30 | Beecham Group Plc | Chemical compound |
| US5330982A (en) * | 1986-12-17 | 1994-07-19 | Glaxo Group Limited | Pharmaceutical composition containing a 5-HT receptor antagonist and an H+ K+ Atpase inhibitor and a method of treating gastrointestingal disorders therewith |
| US5140023A (en) | 1990-04-27 | 1992-08-18 | G. D. Searle & Co. | Azatetracycle compounds |
| KR970701705A (ko) | 1994-03-11 | 1997-04-12 | 오노다 마사요시 | 5-HT₃ 수용체 효능제, 신규한 티아졸 유도체 및 이의 중간체(5-HT₃receptor agonist, novel thiazole derivative, and intermediate therefor) |
| GB0329319D0 (en) * | 2003-12-18 | 2004-01-21 | Alizyme Therapeutics Ltd | Synthesis |
-
2003
- 2003-09-09 GB GBGB0321091.1A patent/GB0321091D0/en not_active Ceased
-
2004
- 2004-07-02 US US10/884,842 patent/US7189852B2/en not_active Expired - Lifetime
- 2004-09-02 TW TW093126521A patent/TW200526661A/zh unknown
- 2004-09-06 WO PCT/GB2004/003820 patent/WO2005023808A2/en active Application Filing
- 2004-09-06 EP EP04768367A patent/EP1664048A2/en not_active Withdrawn
- 2004-09-06 KR KR1020067004708A patent/KR20060092211A/ko not_active Application Discontinuation
- 2004-09-06 CN CNA2004800259716A patent/CN1849320A/zh active Pending
- 2004-09-06 JP JP2006525881A patent/JP2007505089A/ja active Pending
- 2004-09-06 BR BRPI0414200-4A patent/BRPI0414200A/pt not_active IP Right Cessation
- 2004-09-06 CA CA002537536A patent/CA2537536A1/en not_active Abandoned
- 2004-09-06 MX MXPA06002743A patent/MXPA06002743A/es unknown
- 2004-09-06 EA EA200600563A patent/EA200600563A1/ru unknown
- 2004-09-06 AU AU2004270465A patent/AU2004270465A1/en not_active Abandoned
- 2004-09-09 AR ARP040103240A patent/AR045625A1/es not_active Application Discontinuation
-
2006
- 2006-02-14 IL IL173736A patent/IL173736A0/en unknown
- 2006-03-08 ZA ZA200601991A patent/ZA200601991B/xx unknown
- 2006-04-07 NO NO20061575A patent/NO20061575L/no not_active Application Discontinuation
-
2007
- 2007-01-08 US US11/650,740 patent/US20070135641A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20061575L (no) | 2006-06-09 |
| US20050049416A1 (en) | 2005-03-03 |
| ZA200601991B (en) | 2009-08-26 |
| MXPA06002743A (es) | 2006-06-05 |
| WO2005023808A3 (en) | 2005-07-07 |
| TW200526661A (en) | 2005-08-16 |
| EA200600563A1 (ru) | 2006-12-29 |
| US7189852B2 (en) | 2007-03-13 |
| IL173736A0 (en) | 2006-07-05 |
| KR20060092211A (ko) | 2006-08-22 |
| BRPI0414200A (pt) | 2006-10-31 |
| CA2537536A1 (en) | 2005-03-17 |
| GB0321091D0 (en) | 2003-10-08 |
| US20070135641A1 (en) | 2007-06-14 |
| WO2005023808A2 (en) | 2005-03-17 |
| EP1664048A2 (en) | 2006-06-07 |
| AU2004270465A1 (en) | 2005-03-17 |
| CN1849320A (zh) | 2006-10-18 |
| JP2007505089A (ja) | 2007-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |