AR044347A1 - Derivados de diarilmetiliden piperidina, sus preparaciones y sus usos como agonistas de receptores opiodes d - Google Patents

Derivados de diarilmetiliden piperidina, sus preparaciones y sus usos como agonistas de receptores opiodes d

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Publication number
AR044347A1
AR044347A1 ARP040101664A ARP040101664A AR044347A1 AR 044347 A1 AR044347 A1 AR 044347A1 AR P040101664 A ARP040101664 A AR P040101664A AR P040101664 A ARP040101664 A AR P040101664A AR 044347 A1 AR044347 A1 AR 044347A1
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AR
Argentina
Prior art keywords
optionally substituted
alkyl
heterocyclyl
aryl
cycloalkyl
Prior art date
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ARP040101664A
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English (en)
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Astrazeneca Ab
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Publication of AR044347A1 publication Critical patent/AR044347A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Estos son útiles en terapia, en especial en el manejo del dolor y la ansiedad. Reivindicación 1: Un compuesto de fórmula (1), una sal aceptable para uso farmacéutico del mismo, diastereómeros, enantiómeros o sus mezclas, en la cual: R1 se selecciona de hidrógeno, alquilo(C1-6)-O-C(=O), alquilo C1-6 sustituido opcionalmente, cicloalquilo C3-6 sustituido opcionalmente, arilo C6-10 sustituido opcionalmente, heterociclilo C2-9 sustituido opcionalmente, aril(C6-10)-alquilo(C1-3) sustituido opcionalmente, heterociclil(C2-9)-alquilo(C1-3) sustituido opcionalmente y la fórmula (2), en el cual D es un grupo divalente seleccionado de alquileno C1-6 sustituido opcionalmente, fenileno sustituido opcionalmente, fenilenalquilo C1-3 sustituido opcionalmente, heteroarileno C3-5 sustituido opcionalmente y heteroarilen(C3-5)-alquilo(C1-3) sustituido opcionalmente; R2 y R3 se seleccionan, de manera independiente, de hidrógeno, alquilo C1-6 sustituido opcionalmente y cicloalquilo C3- 6 sustituido opcionalmente; y R4 y R5 se seleccionan de manera independiente de -H, alquilo C1-6 sustituido opcionalmente, cicloalquilo C3-8 sustituido opcionalmente, arilo C6-10 sustituido opcionalmente, heterociclilo C2-9 sustituido opcionalmente, aril(C6-10)-alquilo(C1-6) sustituido opcionalmente, heterociclil(C2-9)-alquilo(C1-6) sustituido opcionalmente, -C(=O)-NR8R9 y -C(=O)-R8, donde R8 y R9 se seleccionan de manera independiente de -H, alquilo C1-6 sustituido opcionalmente, cicloalquilo C3-8 sustituido opcionalmente, arilo C6-10 sustituido opcionalmente, heterociclilo C2-9 sustituido opcionalmente, aril(C6-10)-alquilo(C1-6) sustituido opcionalmente y heterociclil(C2-9)-alquilo(C1-6) sustituido opcionalmente.
ARP040101664A 2003-05-16 2004-05-14 Derivados de diarilmetiliden piperidina, sus preparaciones y sus usos como agonistas de receptores opiodes d AR044347A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0301445A SE0301445D0 (sv) 2003-05-16 2003-05-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Publications (1)

Publication Number Publication Date
AR044347A1 true AR044347A1 (es) 2005-09-07

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ARP040101664A AR044347A1 (es) 2003-05-16 2004-05-14 Derivados de diarilmetiliden piperidina, sus preparaciones y sus usos como agonistas de receptores opiodes d

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US (1) US20070066655A1 (es)
EP (1) EP1626960A1 (es)
JP (1) JP2007500739A (es)
KR (1) KR20060003104A (es)
CN (1) CN100415717C (es)
AR (1) AR044347A1 (es)
AU (1) AU2004238616B2 (es)
BR (1) BRPI0410353A (es)
CA (1) CA2525858A1 (es)
CO (1) CO5650250A2 (es)
IS (1) IS8179A (es)
MX (1) MXPA05012116A (es)
NO (1) NO20055997L (es)
NZ (1) NZ543232A (es)
RU (1) RU2005136537A (es)
SE (1) SE0301445D0 (es)
TW (1) TW200510312A (es)
UA (1) UA81309C2 (es)
UY (1) UY28318A1 (es)
WO (1) WO2004101520A1 (es)
ZA (1) ZA200509243B (es)

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MY148880A (en) * 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression
US20090131485A1 (en) * 2007-09-10 2009-05-21 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
WO2016099394A1 (en) * 2014-12-19 2016-06-23 Pharmnovo Ab Novel selective delta-opioid receptor agonists useful for the treatment of pain, anxiety and depression.
ES2808667T3 (es) * 2014-12-19 2021-03-01 Pharmnovo Ab Derivados de diarilmetilideno piperidina y su uso como agonistas del receptor opioide delta
MD3344248T2 (ro) * 2015-09-02 2022-10-31 Trevena Inc Aza-heterociclic cu 6 elemente conținând compuși de modulare a receptorului delta-opioid, metode de utilizare și fabricare a acestora
CN105412076B (zh) * 2015-11-10 2016-08-31 陈艳 化合物在制备治疗小儿腹泻的药物中的用途

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SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0103313D0 (sv) * 2001-10-03 2001-10-03 Astrazeneca Ab Novel compounds
SE0300987D0 (sv) * 2003-04-03 2003-04-03 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

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CN100415717C (zh) 2008-09-03
CO5650250A2 (es) 2006-06-30
EP1626960A1 (en) 2006-02-22
CN1791578A (zh) 2006-06-21
NZ543232A (en) 2008-12-24
ZA200509243B (en) 2007-04-25
UY28318A1 (es) 2004-12-31
JP2007500739A (ja) 2007-01-18
SE0301445D0 (sv) 2003-05-16
RU2005136537A (ru) 2006-06-10
US20070066655A1 (en) 2007-03-22
AU2004238616B2 (en) 2008-10-09
AU2004238616A1 (en) 2004-11-25
BRPI0410353A (pt) 2006-06-13
NO20055997L (no) 2006-02-16
UA81309C2 (en) 2007-12-25
TW200510312A (en) 2005-03-16
IS8179A (is) 2005-12-14
KR20060003104A (ko) 2006-01-09
MXPA05012116A (es) 2006-02-08
WO2004101520A1 (en) 2004-11-25
CA2525858A1 (en) 2004-11-25

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