CN105997990B - 化合物在制备体外抑制产气荚膜梭菌atcc 13124的药物中的用途 - Google Patents
化合物在制备体外抑制产气荚膜梭菌atcc 13124的药物中的用途 Download PDFInfo
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 23
- 241001470651 Clostridium perfringens ATCC 13124 Species 0.000 title claims description 10
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
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- 241000193468 Clostridium perfringens Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
- A01N43/32—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
Abstract
本发明涉及一种治疗小儿腹泻的药物组合物，所述药物组合物包含有效量的化合物和药学上可接受的载体，所述化合物具有下列结构：
Description
本发明是申请号为201510760561.6、申请日为2015年11月10日、发明名称为“一种治疗小儿腹泻的药物组合物”的专利的分案申请。
技术领域
本发明涉及医药领域，具体的说，本发明涉及一种治疗小儿腹泻的药物组合物。
背景技术
小儿腹泻是小儿常见病，其多由各种致病菌引起，近期发现产气荚膜梭菌ATCC13124也是其中的病菌之一。
发明内容
本发明的目的在于提供一种治疗小儿腹泻的药物组合物。
为了实现本发明的目的，本发明提供一种治疗小儿腹泻的化合物，该化合物具有下列结构：
本发明还提供一种治疗小儿腹泻的药物组合物，所述药物组合物包含有效量的化合物和药学上可接受的载体，所述化合物具有下列结构：
优选地，所述药学上可接受的载体为稀释剂、崩解剂、粘合剂、润滑剂、稳定剂或矫正剂。
优选地，所述稀释剂为糖衍生物、淀粉衍生物或纤维素衍生物。
优选地，所述稀释剂为乳糖。
优选地，所述药物组合物为散剂、微粒剂、颗粒剂、胶囊剂或片剂。
本发明还提供化合物在制备治疗小儿腹泻的药物中的用途，该化合物具有下列结构：
优选地，所述腹泻是由产气荚膜梭菌ATCC 13124引起的。
本发明还提供化合物在制备体外抑制产气荚膜梭菌ATCC 13124的药物中的用途，该化合物具有下列结构：
本文所用的术语“药学上可接受的”指不消除本文所述的化合物的生物学活性或性质的物质，如载体或稀释剂。这类物质被施用于个体不导致不希望的生物学作用或者不以有害方式与包含它的组合物中的任何组分相互作用。
如本文所用的术语“药学上可接受的载体”包括任何和所有的溶剂、分散介质、包衣材料、表面活性剂、抗氧化剂、防腐剂(例如抗 菌剂、抗真菌剂)、等渗剂、吸收延迟剂、盐、防腐剂、药物稳定剂、粘合剂、赋形剂、崩解剂、润滑剂、甜味剂、矫味剂、染料等和其组合，这是本领域技术人员所熟知的(例如参见Remington's Pharmaceutical Sciences,18thEd.Mack Printing Company,1990,pp.1289-1329)。除了与活性成分不相容的载体外，在治疗或药物组合物中考虑使用任何常规载体。
本发明的化合物对于引起小儿腹泻的病原菌效果显著，可以开发成临床上有效的新的药物组合物。
具体实施方式
以下通过具体实施方式的描述对本发明作进一步说明，但这并非是对本发明的限制，本领域技术人员根据本发明的基本思想，可以做出各种修改或改进，但是只要不脱离本发明的基本思想，均在本发明的范围之内。
实验例本发明化合物在制备体外抑制产气荚膜梭菌ATCC 13124的药物中的用途的研究
抑菌试验
使用下列化合物，采用本领域中经典的滤纸片法来进行抑菌试验，其中：
目标化合物的结构式为：
供试菌种产气荚膜梭菌ATCC 13124购自上海北诺生物科技有限公司。
培养液
营养琼脂和营养肉汤，购自北京中科晨宇实验设备有限公司。
试验方法
将产气荚膜梭菌ATCC 13124接种于琼脂平板营养液平面上，接种时均匀密布。
称取目标化合物0.01克，加入20000毫升无菌水，超声30分钟，然后0.22μm的微孔滤膜过滤，得到溶液。镊取无菌圆形滤纸片，喷洒上述溶液至完全润湿，贴在已接种细菌的琼脂平板营养液平面上。将琼脂平板置于37℃的培养箱内，温育4小时。测量抑菌环的直径。测定3次取平均值。
1.4结果
产气荚膜梭菌ATCC 13124的抑菌环的平均直径为14.22mm，这表明目标化合物具有极强的体外抑制产气荚膜梭菌ATCC 13124的效果。
Claims (1)
1.化合物在制备体外抑制产气荚膜梭菌ATCC 13124的药物中的用途，其特征在于，该化合物具有下列结构：
所述药物通过下列方法制成：
称取所述化合物0.01克，加入20000毫升无菌水，超声30分钟，然后0.22μm的微孔滤膜过滤，即得。
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| CN201510760561.6A CN105412076B (zh) | 2015-11-10 | 2015-11-10 | 化合物在制备治疗小儿腹泻的药物中的用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101460177A (zh) * | 2005-07-15 | 2009-06-17 | 纽约州州立大学研究基金会 | 用于抑制细菌芽孢的非抗菌四环素剂型的应用 |
| CN104770405A (zh) * | 2015-04-21 | 2015-07-15 | 王志效 | 一种血站用于消毒的喷雾剂 |
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| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| CN102552239B (zh) * | 2011-12-31 | 2013-10-30 | 沈阳药科大学 | 从甘草药渣中制备抗炎、抗肿瘤有效成分组的方法及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101460177A (zh) * | 2005-07-15 | 2009-06-17 | 纽约州州立大学研究基金会 | 用于抑制细菌芽孢的非抗菌四环素剂型的应用 |
| CN104770405A (zh) * | 2015-04-21 | 2015-07-15 | 王志效 | 一种血站用于消毒的喷雾剂 |
Non-Patent Citations (1)
| Title |
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| 低浓度恩诺沙星在离体肠道模拟系统中对人体肠道菌群的影响;刘健华等;《中国兽医杂志》;20031231;第39卷(第7期);38-41 * |
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| CN105412076A (zh) | 2016-03-23 |
| CN105997990A (zh) | 2016-10-12 |
| CN105412076B (zh) | 2016-08-31 |
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