CN105997990A - 一种治疗小儿腹泻的药物组合物 - Google Patents
一种治疗小儿腹泻的药物组合物 Download PDFInfo
- Publication number
- CN105997990A CN105997990A CN201610344559.5A CN201610344559A CN105997990A CN 105997990 A CN105997990 A CN 105997990A CN 201610344559 A CN201610344559 A CN 201610344559A CN 105997990 A CN105997990 A CN 105997990A
- Authority
- CN
- China
- Prior art keywords
- medicine composition
- compound
- infantile diarrhea
- treating infantile
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 12
- 208000019637 Infantile Diarrhea Diseases 0.000 title abstract description 12
- 239000000203 mixture Substances 0.000 title abstract description 6
- 229940079593 drug Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 241000193468 Clostridium perfringens Species 0.000 claims description 9
- 230000005764 inhibitory process Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000004531 microgranule Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000006189 buccal tablet Substances 0.000 claims 1
- 229940046011 buccal tablet Drugs 0.000 claims 1
- 239000007919 dispersible tablet Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 abstract description 4
- 244000052616 bacterial pathogen Species 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 0 CC[C@@](C1)[C@](C)C(*C)CC1*(C)=C([C@@]1C)OCCC1=C Chemical compound CC[C@@](C1)[C@](C)C(*C)CC1*(C)=C([C@@]1C)OCCC1=C 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000003070 absorption delaying agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- -1 correctives Substances 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
- A01N43/32—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610344559.5A CN105997990B (zh) | 2015-11-10 | 2015-11-10 | 化合物在制备体外抑制产气荚膜梭菌atcc 13124的药物中的用途 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610344559.5A CN105997990B (zh) | 2015-11-10 | 2015-11-10 | 化合物在制备体外抑制产气荚膜梭菌atcc 13124的药物中的用途 |
CN201510760561.6A CN105412076B (zh) | 2015-11-10 | 2015-11-10 | 化合物在制备治疗小儿腹泻的药物中的用途 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510760561.6A Division CN105412076B (zh) | 2015-11-10 | 2015-11-10 | 化合物在制备治疗小儿腹泻的药物中的用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105997990A true CN105997990A (zh) | 2016-10-12 |
CN105997990B CN105997990B (zh) | 2017-08-29 |
Family
ID=55490933
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510760561.6A Expired - Fee Related CN105412076B (zh) | 2015-11-10 | 2015-11-10 | 化合物在制备治疗小儿腹泻的药物中的用途 |
CN201610344559.5A Active CN105997990B (zh) | 2015-11-10 | 2015-11-10 | 化合物在制备体外抑制产气荚膜梭菌atcc 13124的药物中的用途 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510760561.6A Expired - Fee Related CN105412076B (zh) | 2015-11-10 | 2015-11-10 | 化合物在制备治疗小儿腹泻的药物中的用途 |
Country Status (1)
Country | Link |
---|---|
CN (2) | CN105412076B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105748478B (zh) * | 2016-04-08 | 2016-10-12 | 郭晓辉 | 一种治疗小儿腹泻的药物 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101460177A (zh) * | 2005-07-15 | 2009-06-17 | 纽约州州立大学研究基金会 | 用于抑制细菌芽孢的非抗菌四环素剂型的应用 |
CN102552239A (zh) * | 2011-12-31 | 2012-07-11 | 沈阳药科大学 | 从甘草药渣中制备抗炎、抗肿瘤有效成分组的方法及其应用 |
CN104770405A (zh) * | 2015-04-21 | 2015-07-15 | 王志效 | 一种血站用于消毒的喷雾剂 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
-
2015
- 2015-11-10 CN CN201510760561.6A patent/CN105412076B/zh not_active Expired - Fee Related
- 2015-11-10 CN CN201610344559.5A patent/CN105997990B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101460177A (zh) * | 2005-07-15 | 2009-06-17 | 纽约州州立大学研究基金会 | 用于抑制细菌芽孢的非抗菌四环素剂型的应用 |
CN102552239A (zh) * | 2011-12-31 | 2012-07-11 | 沈阳药科大学 | 从甘草药渣中制备抗炎、抗肿瘤有效成分组的方法及其应用 |
CN104770405A (zh) * | 2015-04-21 | 2015-07-15 | 王志效 | 一种血站用于消毒的喷雾剂 |
Non-Patent Citations (1)
Title |
---|
刘健华等: "低浓度恩诺沙星在离体肠道模拟系统中对人体肠道菌群的影响", 《中国兽医杂志》 * |
Also Published As
Publication number | Publication date |
---|---|
CN105412076A (zh) | 2016-03-23 |
CN105997990B (zh) | 2017-08-29 |
CN105412076B (zh) | 2016-08-31 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Na Inventor before: Xing Lili |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20170405 Address after: 071003 Hebei Province, Baoding City area Yonghua No. 9 North Street Applicant after: Li Na Address before: 071003 Hebei Province, Baoding City area Yonghua No. 9 North Street Applicant before: Xing Lili |
|
CB03 | Change of inventor or designer information |
Inventor after: Shan Feng Inventor before: Li Na |
|
CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20170808 Address after: Department of Laboratory of Affiliated Hospital of Jining Medical College No. 79 Guhuai road 272029 of Shandong Province, Jining City Applicant after: Shan Feng Address before: 071003 Hebei Province, Baoding City area Yonghua No. 9 North Street Applicant before: Li Na |
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TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant |