AR043205A1 - BENEFIT DERIVATIVES REPLACED WITH MACROCICLIC TRIMEROS - Google Patents

BENEFIT DERIVATIVES REPLACED WITH MACROCICLIC TRIMEROS

Info

Publication number
AR043205A1
AR043205A1 ARP040100490A ARP040100490A AR043205A1 AR 043205 A1 AR043205 A1 AR 043205A1 AR P040100490 A ARP040100490 A AR P040100490A AR P040100490 A ARP040100490 A AR P040100490A AR 043205 A1 AR043205 A1 AR 043205A1
Authority
AR
Argentina
Prior art keywords
chz1
chz2
atom
meaning
trimeros
Prior art date
Application number
ARP040100490A
Other languages
Spanish (es)
Inventor
Schirmer Heiko Dr
Hilmar Weinmann
Platzek Johannes Dr
Martin Jose Luis Dr
Juan R Harto
Riefke Bjom Dr
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of AR043205A1 publication Critical patent/AR043205A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System

Abstract

Complejos metálicos apropiados como sustancias de contraste de la fórmula general (1). A1 representa los radicales: -CONR1-(CH2)n-NR2-(CO-CHZ1-NH)m-CO-CHZ2-K, -CONR1-(CH2)p-(CONR2CH2)m-CHOH-CH2-K, -CH2-O-CH2)p-CHOH-CH2-K, -CH2-O-(CH2)n-NR1-(CO-CHZ1-NH)m-CO-CHZ2-K, -CH2-NR1-CO-(CHZ1-NH-CO)m-CHZ2-K, A2 tiene el mismo significado que A1 o en el caso que A1 tenga el significado mencionado en primer término también puede ser el radical -NR1-CO-(NR1)m-(CH2)p-NR2-(CO-CHZ1-NH)m-CO-CHZ2-K, donde R1 y R2 son independientemente un átomo de H, un grupo alquilo C1-2 o un grupo alquilo C1-12 monohidroxi, Z1 y Z2 son independientemente entre sí un átomo de H o un grupo metilo, n es el número 2-4, m es el número 0 o 1 y p es el número 1-4, K representa un macrociclo de la fórmula (2) done X tiene el significado de un átomo de H o un equivalente de ión metálico de número atómico 20-29, 39, 42, 44 o 57-83, con la condición de que por lo menos dos X representan equivalentes de iones metálicos y que ls grupos carboxi libres que puedan estar presentes puedan estar presentes como sales de bases orgánicas y/o inorgánicas o aminoácidos o amidas de aminoácidos.Suitable metal complexes as contrast substances of the general formula (1). A1 represents the radicals: -CONR1- (CH2) n-NR2- (CO-CHZ1-NH) m-CO-CHZ2-K, -CONR1- (CH2) p- (CONR2CH2) m-CHOH-CH2-K, - CH2-O-CH2) p-CHOH-CH2-K, -CH2-O- (CH2) n-NR1- (CO-CHZ1-NH) m-CO-CHZ2-K, -CH2-NR1-CO- (CHZ1 -NH-CO) m-CHZ2-K, A2 has the same meaning as A1 or in the case that A1 has the meaning mentioned in the first term it can also be the radical -NR1-CO- (NR1) m- (CH2) p -NR2- (CO-CHZ1-NH) m-CO-CHZ2-K, where R1 and R2 are independently an H atom, a C1-2 alkyl group or a monohydroxy C1-12 alkyl group, Z1 and Z2 are independently between if an atom of H or a methyl group, n is the number 2-4, m is the number 0 or 1 and p is the number 1-4, K represents a macrocycle of the formula (2) where X has the meaning of a H atom or a metal ion equivalent of atomic number 20-29, 39, 42, 44 or 57-83, with the proviso that at least two Xs represent metal ion equivalents and that the free carboxy groups that may be present may be present c as salts of organic and / or inorganic bases or amino acids or amino acid amides.

ARP040100490A 2003-02-19 2004-02-18 BENEFIT DERIVATIVES REPLACED WITH MACROCICLIC TRIMEROS AR043205A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10307759A DE10307759B3 (en) 2003-02-19 2003-02-19 Trimers of macrocyclically substituted benzene derivatives, their production and use as contrast media and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
AR043205A1 true AR043205A1 (en) 2005-07-20

Family

ID=32891780

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100490A AR043205A1 (en) 2003-02-19 2004-02-18 BENEFIT DERIVATIVES REPLACED WITH MACROCICLIC TRIMEROS

Country Status (16)

Country Link
EP (1) EP1594851A1 (en)
JP (1) JP2006514664A (en)
KR (1) KR20050105474A (en)
CN (1) CN1753878A (en)
AR (1) AR043205A1 (en)
AU (1) AU2003290032B2 (en)
BR (1) BR0318125A (en)
CA (1) CA2516467A1 (en)
CR (1) CR7937A (en)
DE (1) DE10307759B3 (en)
EC (1) ECSP056026A (en)
MX (1) MXPA05008781A (en)
NO (1) NO20054291L (en)
RU (1) RU2005128834A (en)
WO (1) WO2004074267A1 (en)
ZA (1) ZA200507437B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DE102004023093B3 (en) 2004-05-05 2006-03-02 Schering Ag Trimere macrocyclic substituted halogen-benzene derivatives
DE102004026103A1 (en) * 2004-05-25 2005-12-22 Schering Ag Trimere macrocyclic substituted aminoisophthalic acid-halogenated benzene derivatives
ES2257152B1 (en) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. COMBINATIONS THAT INCLUDE ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS.
DE102007058220A1 (en) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft New metal complexes useful e.g. for manufacturing agent for X-ray diagnostics and magnetic resonance tomography-diagnostics of brain infarcts and liver tumor, and/or space-process in liver and abdomen tumors and musculoskeletal tumors
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2608785B1 (en) * 2010-08-26 2016-08-17 Kunyuan Cui Lipomacrocycles and uses thereof
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
CN104672259B (en) * 2015-02-02 2017-04-05 湖北大学 A kind of rare-earth europium containing iodine (III) complex and its preparation method and application
CN104721844B (en) * 2015-02-02 2017-11-03 湖北大学 A kind of new CT, MRI, the functional microsphere of rare-earth fluorescent three and its preparation method and application
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN105254529B (en) * 2015-09-21 2017-05-31 西南石油大学 A kind of preparation method of tree-like schiff bases corrosion inhibiter
CN110035996B (en) 2016-11-28 2022-08-09 拜耳医药股份公司 Novel highly relaxant gadolinium chelates for magnetic resonance imaging
CN107445911B (en) * 2017-06-19 2019-07-05 南京科技职业学院 Two core mr contrast agents containing gadolinium of one kind and its preparation and application
WO2020104602A1 (en) 2018-11-23 2020-05-28 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
ATE195432T1 (en) * 1993-06-02 2000-09-15 Bracco Spa IODINATED PARAMAGNETIC CHELATES AND THEIR USE AS CONTRAST AGENTS
FR2736051B3 (en) * 1995-06-29 1997-09-26 Guerbet Sa METAL COMPLEXES OF POLYAMINOACIDS, THEIR PREPARATION PROCESS AND THEIR USE IN DIAGNOSTIC IMAGING
FR2793795B1 (en) * 1999-05-21 2001-08-03 Guerbet Sa ISOMERS OF TETRAMIDS OF THE ACID GADOLINIUM COMPLEX (1,4,7,10-TETRAZACYCLODODECANE) 1,4,7,10-TETRA (2-GLUTARIC) THEIR PREPARATION PROCESS AND THEIR APPLICATION IN MEDICAL IMAGING
FR2794744B1 (en) * 1999-06-09 2001-09-21 Guerbet Sa METAL COMPLEXES OF BICYCLIC POLYAMINOACIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN MEDICAL IMAGING

Also Published As

Publication number Publication date
ZA200507437B (en) 2007-02-28
CR7937A (en) 2006-02-07
NO20054291D0 (en) 2005-09-16
JP2006514664A (en) 2006-05-11
MXPA05008781A (en) 2006-03-10
WO2004074267A1 (en) 2004-09-02
EP1594851A1 (en) 2005-11-16
DE10307759B3 (en) 2004-11-18
KR20050105474A (en) 2005-11-04
CN1753878A (en) 2006-03-29
RU2005128834A (en) 2006-03-20
CA2516467A1 (en) 2004-09-02
BR0318125A (en) 2006-02-07
NO20054291L (en) 2005-11-17
AU2003290032A1 (en) 2004-09-09
ECSP056026A (en) 2006-01-27
AU2003290032B2 (en) 2009-04-23

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